Annona senegalensis
Species
KNApSAcK Entry
| Organism name | Annona senegalensis |
|---|---|
| Genus | Annona |
| Family | Annonaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Annona senegalensis |
|---|---|
| Linked NCBI taxonomy ID | 306945 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Annonaceae |
|---|---|
| ID | 22140 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Magnoliophyta |
|---|---|
| ID | 3398 |
Metabolite list (8)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00044312
|
Senegalene
|
No. 6 | No. 70 |
|
||||
|
C00001822
|
Boldine
/ d-Boldine |
CHEMBL388342
CHEMBL1321247 CHEMBL1437753 |
C011686
|
34 / 32 / 35 | No. 20 | No. 4 |
|
|
|
C00001869
|
Isoboldine
/ (S)-Isoboldine |
CHEMBL462880
|
19 / 22 / 55 | No. 20 | No. 4 |
|
||
|
C00001872
|
Isocorydine
/ (+)-Isocorydine / L-(+)-Isocorydine / (S)-(+)-Isocorydine |
CHEMBL489525
CHEMBL1376826 |
14 / 7 / 10 | No. 20 | No. 4 |
|
||
|
C00025625
|
Roemerine
/ (-)-Remerine / (-)-Aporheine / (-)-Roemerine |
CHEMBL36654
CHEMBL483825 |
C030169
|
23 / 10 / 13 | No. 20 | No. 4 |
|
|
|
C00001807
|
Anonaine
/ (-)-Anonaine / (R)-Annonaine |
CHEMBL401798
|
C098138
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00002631
|
(+)-Lirioresinol B
/ (+)-Syringaresinol |
CHEMBL361362
CHEMBL402653 |
C042192
|
1 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00001878
|
Liriodenine
/ Oxoushinsunine / Spermatheridine |
CHEMBL37736
|
C026980
|
5 / 3 / 1 | No. 74 |
|
Human Protein / Gene in interactions
52 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001822 C00001869 C00001872 C00025625 | 1 / 4 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001822 C00001869 C00001872 C00025625 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001822 C00001869 C00001872 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001822 C00001869 C00001872 | 1 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001822 C00001869 C00025625 | 1 / 2 |
| O75496 | Geminin | Unclassified protein | C00001822 C00001872 C00025625 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00001822 C00001869 C00025625 | 2 / 5 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001822 C00001869 C00001872 | 3 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001822 C00001869 C00001872 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001822 C00001869 C00025625 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001822 C00001869 C00001872 | 0 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001822 C00001869 C00001872 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001822 C00001869 C00025625 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001822 C00001869 C00001872 | 0 / 0 |
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Enzyme | C00001807 C00001878 C00025625 | 0 / 0 |
| P17787 | Neuronal acetylcholine receptor subunit beta-2 | CHRN beta | C00001822 C00001878 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001822 C00025625 | 0 / 0 |
| P43681 | Neuronal acetylcholine receptor subunit alpha-4 | CHRN alpha | C00001822 C00001878 | 1 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001822 C00025625 | 1 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001822 C00001869 | 4 / 3 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001822 C00025625 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001822 C00025625 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001822 C00025625 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001822 C00025625 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001822 C00001869 | 2 / 2 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00001822 C00025625 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001822 C00001872 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00001872 C00025625 | 0 / 0 |
| P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRN alpha | C00001822 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00001822 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00025625 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00025625 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00025625 | 2 / 0 |
| P55210 | Caspase-7 | C14 | C00001869 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001822 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001822 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002631 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00025625 | 0 / 0 |
| P32297 | Neuronal acetylcholine receptor subunit alpha-3 | CHRN alpha | C00001878 | 1 / 0 |
| P30926 | Neuronal acetylcholine receptor subunit beta-4 | CHRN beta | C00001878 | 0 / 0 |
| O14727 | Apoptotic protease-activating factor 1 | Unclassified protein | C00025625 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00001872 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001822 | 11 / 10 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001869 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001822 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00025625 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00001872 | 1 / 0 |
| P29466 | Caspase-1 | C14 | C00001869 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00025625 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001822 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001869 | 7 / 37 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001822 | 1 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (45)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600513 | Epilepsy, nocturnal frontal lobe, 1; enfl1 |
P43681
|
| #605375 | Epilepsy, nocturnal frontal lobe, 3; enfl3 |
P17787
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #612052 | Smoking as a quantitative trait locus 3; sqtl3 |
P32297
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (70)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00807 | Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) |
P17787
(related)
P43681 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|