PCIDB

Stephania excentrica H.S.Lo

Species

KNApSAcK Entry

Organism name Stephania excentrica H.S.Lo
Genus Stephania
Family Menispermaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Stephania
Linked NCBI taxonomy ID 147243
Linked level genus

Family

Family in NCBI taxonomy Menispermaceae
ID 3455

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class eudicotyledons
ID 71240

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00025602 External link 512 l-Curine
/ (-)-Curine
/ l-Bebeerine
/ Aristolochine
/ (-)-Bebeerine
/ Aristolochine(C36 alkaloid)
CHEMBL1169627
13 / 6 / 5 No. 10 No. 4
C00025310 External link 512 Homoaromoline
/ (+)-Homoaromoline
/ (+)-Thalrugosamine
CHEMBL507220
CHEMBL503522
CHEMBL509855
CHEMBL1185978
No. 10 No. 4
C00025625 External link 512 Roemerine
/ (-)-Remerine
/ (-)-Aporheine
/ (-)-Roemerine
CHEMBL36654
CHEMBL483825
C030169
23 / 10 / 13 No. 20 No. 4
C00025996 External link 512 Oxoputerine
No. 74
C00025992 External link 512 Oxoanolobine
No. 74
C00025652 External link 512 d-Coclaurine
/ Sanjoinine K
/ (R)-Coclaurine
/ (+)-Coclaurine
/ (+)-R-Coclaurine
CHEMBL256448
CHEMBL453291
CHEMBL446211
8 / 17 / 10 No. 253 No. 4
C00025102 External link 512 Aknadinine
/ 4-Demethylhasubanonine
/ O4-Demethylhasubanonine
CHEMBL1098359
C099121
3 / 0 / 0 No. 559 No. 4
C00025872 External link 512 Excentricine
/ (+)-Excentricine
No. 3650

Human Protein / Gene in interactions

37 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00025602 C00025625 C00025652 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00025602 C00025652 4 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00025602 C00025652 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00025602 C00025625 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00025625 C00025652 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00025602 C00025625 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00025102 C00025602 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00025102 C00025602 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00025602 C00025625 0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00025625 1 / 1
Q14761 Protein tyrosine phosphatase receptor type C-associated protein Enzyme C00025625 0 / 0
P39748 Flap endonuclease 1 Enzyme C00025625 0 / 0
P42858 Huntingtin Unclassified protein C00025602 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00025625 2 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00025625 1 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00025625 0 / 0
P47898 5-hydroxytryptamine receptor 5A Serotonin receptor C00025602 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00025652 7 / 3
P41145 Kappa-type opioid receptor Opioid receptor C00025102 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00025625 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00025625 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00025625 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00025625 1 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00025625 0 / 0
P04062 Glucosylceramidase Enzyme C00025652 6 / 4
O14727 Apoptotic protease-activating factor 1 Unclassified protein C00025625 0 / 0
O43603 Galanin receptor type 2 Galanin receptor C00025602 0 / 0
P06746 DNA polymerase beta Enzyme C00025625 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00025652 0 / 0
P14618 Pyruvate kinase PKM Enzyme C00025652 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00025625 1 / 1
O00255 Menin Unclassified protein C00025625 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00025625 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00025625 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00025625 1 / 4
Q99700 Ataxin-2 Unclassified protein C00025602 1 / 1
P43351 DNA repair protein RAD52 homolog Unclassified protein C00025602 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (29)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143100 Huntington disease; hd P42858
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#166350 Osseous heteroplasia, progressive; poh P63092
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (24)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)