Stephania kwangsiensis H.S.Lo.
Species
KNApSAcK Entry
| Organism name | Stephania kwangsiensis H.S.Lo. |
|---|---|
| Genus | Stephania |
| Family | Menispermaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Stephania |
|---|---|
| Linked NCBI taxonomy ID | 147243 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Menispermaceae |
|---|---|
| ID | 3455 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00025625
|
Roemerine
/ (-)-Remerine / (-)-Aporheine / (-)-Roemerine |
CHEMBL36654
CHEMBL483825 |
C030169
|
23 / 10 / 13 | No. 20 | No. 4 |
|
|
|
C00025630
|
Stephanine
/ l-Stephanine / (-)-Stephanine / (R)-(-)-Stephanine |
CHEMBL601020
|
C054160
|
1 / 0 / 0 | No. 20 | No. 4 |
|
|
|
C00025846
|
Dehydrostephanine
/ 1,2-Methylenedioxy-8-methoxydehydroaporphine |
C030171
|
No. 416 |
|
||||
|
C00025845
|
Dehydroroemerine
/ Dehydroremerine / 6a,7-Didehydroaporheine |
CHEMBL1171263
|
C030170
|
No. 416 |
|
|||
|
C00025852
|
Dihydropalmatine
|
No. 3390 |
|
Human Protein / Gene in interactions
24 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00025625 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00025625 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00025625 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00025625 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00025630 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00025625 | 1 / 0 |
| Q14761 | Protein tyrosine phosphatase receptor type C-associated protein | Enzyme | C00025625 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00025625 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00025625 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00025625 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00025625 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00025625 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00025625 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00025625 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00025625 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00025625 | 0 / 0 |
| O14727 | Apoptotic protease-activating factor 1 | Unclassified protein | C00025625 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00025625 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00025625 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00025625 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00025625 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00025625 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00025625 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00025625 | 0 / 0 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (10)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114500 | Colorectal cancer; crc |
P84022
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (13)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|