Chamaerops humilis
Species
KNApSAcK Entry
| Organism name | Chamaerops humilis |
|---|---|
| Genus | Chamaerops |
| Family | Palmae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Chamaerops humilis |
|---|---|
| Linked NCBI taxonomy ID | 54446 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Arecaceae |
|---|---|
| ID | 4710 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00004461
|
Tricin 5-glucoside
/ Tricin 5-O-beta-D-glucopyranoside |
CHEMBL1224897
|
No. 2 | No. 15 |
|
|||
|
C00009079
|
ent-Epicatechin-(4alpha->6)-ent-epicatechin
|
CHEMBL506487
CHEMBL502984 CHEMBL451115 |
No. 16 | No. 19 |
|
|||
|
C00009080
|
ent-Epicatechin-(4alpha->8)-ent-epicatechin
|
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
20 / 7 / 8 | No. 16 | No. 19 |
|
||
|
C00002917
|
Epicatechin-(4beta->8)-ent-epicatechin
|
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
20 / 7 / 8 | No. 16 | No. 19 |
|
||
|
C00000947
|
D-Catechol
/ D-Catechin / Teafuran 30A / (+)-Catechin / Dexcyanidanol / (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol |
CHEMBL80941
CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912 |
D002392
|
85 / 58 / 54 | 91 / 13 | No. 52 | No. 14 |
|
|
C00000957
|
(+)-Epicatechin
/ ent-Epicatechin |
CHEMBL80941
CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912 |
85 / 58 / 54 | No. 52 | No. 14 |
|
||
|
C00001170
|
(+)-Quercitol
|
CHEMBL34244
CHEMBL37104 CHEMBL354060 CHEMBL467977 CHEMBL1950778 |
No. 795 |
|
Human Protein / Gene in interactions
87 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000947 C00000957 C00002917 C00009080 | 1 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00000947 C00000957 C00002917 C00009080 | 1 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00000947 C00000957 C00002917 C00009080 | 1 / 1 |
| Q05655 | Protein kinase C delta type | Delta | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00000947 C00000957 C00002917 C00009080 | 0 / 1 |
| Q05513 | Protein kinase C zeta type | Iota | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000947 C00000957 C00002917 C00009080 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000947 C00000957 C00002917 C00009080 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000947 C00000957 C00002917 C00009080 | 3 / 3 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000947 C00000957 C00002917 C00009080 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000947 C00000957 C00002917 C00009080 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000947 C00000957 | 4 / 3 |
| P49327 | Fatty acid synthase | Transferase | C00000947 C00000957 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00000947 C00000957 | 1 / 2 |
| P54132 | Bloom syndrome protein | Enzyme | C00000947 C00000957 | 1 / 2 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00000947 C00000957 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000947 C00000957 | 2 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000947 C00000957 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000947 C00000957 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00000947 C00000957 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000947 C00000957 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000947 C00000957 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000947 C00000957 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00000947 C00000957 | 1 / 2 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000947 C00000957 | 0 / 0 |
| P07998 | Ribonuclease pancreatic | Enzyme | C00000947 C00000957 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000947 C00000957 | 2 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000947 C00000957 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00000947 C00000957 | 0 / 0 |
| P07711 | Cathepsin L1 | C1A | C00000947 C00000957 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000947 C00000957 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00000947 C00000957 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00000947 C00000957 | 3 / 1 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000947 C00000957 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00000947 C00000957 | 4 / 2 |
| P04745 | Alpha-amylase 1 | Enzyme | C00000947 C00000957 | 0 / 0 |
| P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00002917 C00009080 | 0 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00000947 C00000957 | 2 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000947 C00000957 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00000947 C00000957 | 0 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00000947 C00000957 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000947 C00000957 | 1 / 1 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000947 C00000957 | 0 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000947 C00000957 | 3 / 2 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000947 C00000957 | 2 / 2 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000947 C00000957 | 5 / 2 |
| P00374 | Dihydrofolate reductase | Oxidoreductase | C00000947 C00000957 | 1 / 1 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000947 C00000957 | 0 / 0 |
| P23467 | Receptor-type tyrosine-protein phosphatase beta | Receptor tyrosine-protein phosphatase | C00002917 C00009080 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000947 C00000957 | 0 / 0 |
| P28907 | ADP-ribosyl cyclase 1 | Enzyme | C00000947 C00000957 | 0 / 1 |
| Q8N1Q1 | Carbonic anhydrase 13 | Lyase | C00000947 C00000957 | 0 / 0 |
| P52209 | 6-phosphogluconate dehydrogenase, decarboxylating | Enzyme | C00000947 C00000957 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000947 C00000957 | 0 / 0 |
| Q6W5P4 | Neuropeptide S receptor | Neuropeptide receptor | C00000947 C00000957 | 1 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000947 C00000957 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000947 C00000957 | 5 / 1 |
| P02768 | Serum albumin | Secreted protein | C00000947 C00000957 | 0 / 0 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00000947 C00000957 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00000947 C00000957 | 1 / 1 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00000947 C00000957 | 0 / 7 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000947 C00000957 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000947 C00000957 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000947 C00000957 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000947 C00000957 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000947 C00000957 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00000947 C00000957 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000947 C00000957 | 1 / 2 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00000947 C00000957 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000947 C00000957 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000947 C00000957 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000947 C00000957 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00000947 C00000957 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000947 C00000957 | 3 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000947 C00000957 | 0 / 3 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000947 C00000957 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000947 C00000957 | 4 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000947 C00000957 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000947 C00000957 | 3 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00000947 C00000957 | 0 / 0 |
91 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 |
C00000947
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000947
|
| 302 | ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV | annexin A2 |
C00000947
|
| 393 | ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115 | Rho GTPase activating protein 4 |
C00000947
|
| 468 | ATF4, CREB-2, CREB2, TAXREB67, TXREB | activating transcription factor 4 |
C00000947
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00000947
|
| 2683 | B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) |
C00000947
|
| 56751 | BARHL1 | BarH-like homeobox 1 |
C00000947
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000947
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000947
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00000947
|
| 388962 | BOLA3, MMDS2 | bolA family member 3 |
C00000947
|
| 79184 | BRCC3, BRCC36, C6.1A, CXorf53 | BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) |
C00000947
|
| 694 | BTG1 | B-cell translocation gene 1, anti-proliferative |
C00000947
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000947
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00000947
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00000947
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000947
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00000947
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00000947
|
| 930 | CD19, B4, CVID3 | CD19 molecule |
C00000947
|
| 975 | CD81, CVID6, S5.7, TAPA1, TSPAN28 | CD81 molecule |
C00000947
|
| 928 | CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 | CD9 molecule |
C00000947
|
| 1054 | CEBPG, GPE1BP, IG/EBP-1 | CCAAT/enhancer binding protein (C/EBP), gamma |
C00000947
|
| 10978 | CLP1, HEAB, hClp1 | cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) |
C00000947
|
| 10063 | COX17 | COX17 cytochrome c oxidase copper chaperone |
C00000947
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00000947
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00000947
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000947
|
| 7913 | DEK, D6S231E | DEK oncogene |
C00000947
|
| 1786 | DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT | DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) |
C00000947
|
| 2130 | EWSR1, EWS, bK984G1.4 | EWS RNA-binding protein 1 |
C00000947
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00000947
|
| 2323 | FLT3LG, FL, FLT3L | fms-related tyrosine kinase 3 ligand |
C00000947
|
| 2495 | FTH1, FHC, FTH, FTHL6, PIG15, PLIF | ferritin, heavy polypeptide 1 (EC:1.16.3.1) |
C00000947
|
| 2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00000947
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00000947
|
| 3054 | HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, VCAF | host cell factor C1 (VP16-accessory protein) |
C00000947
|
| 3162 | HMOX1, HMOX1D, HO-1, HSP32, bK286B10 | heme oxygenase (decycling) 1 (EC:1.14.99.3) |
C00000947
|
| 3232 | HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1 | homeobox D3 |
C00000947
|
| 3329 | HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 | heat shock 60kDa protein 1 (chaperonin) |
C00000947
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00000947
|
| 3586 | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF | interleukin 10 |
C00000947
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00000947
|
| 3559 | IL2RA, CD25, IDDM10, IL2R, TCGFR | interleukin 2 receptor, alpha |
C00000947
|
| 9235 | IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd | interleukin 32 |
C00000947
|
| 3662 | IRF4, LSIRF, MUM1, NF-EM5 | interferon regulatory factor 4 |
C00000947
|
| 3683 | ITGAL, CD11A, LFA-1, LFA1A | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) |
C00000947
|
| 3689 | ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) |
C00000947
|
| 4067 | LYN, JTK8, p53Lyn, p56Lyn | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) |
C00000947
|
| 5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00000947
|
| 5605 | MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 | mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) |
C00000947
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00000947
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00000947
|
| 4282 | MIF, GIF, GLIF, MMIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) |
C00000947
|
| 64975 | MRPL41, BMRP, MRP-L27, MRPL27, RPML27 | mitochondrial ribosomal protein L41 |
C00000947
|
| 4493 | MT1E, MT1, MTD | metallothionein 1E |
C00000947
|
| 653361 | NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox | neutrophil cytosolic factor 1 |
C00000947
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00000947
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00000947
|
| 4851 | NOTCH1, TAN1, hN1 | notch 1 |
C00000947
|
| 4869 | NPM1, B23, NPM | nucleophosmin (nucleolar phosphoprotein B23, numatrin) |
C00000947
|
| 5175 | PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM | platelet/endothelial cell adhesion molecule 1 |
C00000947
|
| 5187 | PER1, PER, RIGUI, hPER | period circadian clock 1 |
C00000947
|
| 5327 | PLAT, T-PA, TPA | plasminogen activator, tissue (EC:3.4.21.68) |
C00000947
|
| 5328 | PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA | plasminogen activator, urokinase (EC:3.4.21.73) |
C00000947
|
| 7916 | PRRC2A, BAT2, D6S51, D6S51E, G2 | proline-rich coiled-coil 2A |
C00000947
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00000947
|
| 5747 | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK | protein tyrosine kinase 2 (EC:2.7.10.2) |
C00000947
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00000947
|
| 5915 | RARB, HAP, NR1B2, RRB2 | retinoic acid receptor, beta |
C00000947
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00000947
|
| 6128 | RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 | ribosomal protein L6 |
C00000947
|
| 6285 | S100B, NEF, S100, S100-B, S100beta | S100 calcium binding protein B |
C00000947
|
| 6286 | S100P, MIG9 | S100 calcium binding protein P |
C00000947
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00000947
|
| 7536 | SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 | splicing factor 1 |
C00000947
|
| 6574 | SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1 | solute carrier family 20 (phosphate transporter), member 1 |
C00000947
|
| 6699 | SPRR1B, CORNIFIN, GADD33, SPRR1 | small proline-rich protein 1B |
C00000947
|
| 6772 | STAT1, CANDF7, ISGF-3, STAT91 | signal transducer and activator of transcription 1, 91kDa |
C00000947
|
| 6777 | STAT5B, STAT5 | signal transducer and activator of transcription 5B |
C00000947
|
| 6778 | STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C | signal transducer and activator of transcription 6, interleukin-4 induced |
C00000947
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000947
|
| 6932 | TCF7, TCF-1 | transcription factor 7 (T-cell specific, HMG-box) |
C00000947
|
| 7083 | TK1, TK2 | thymidine kinase 1, soluble (EC:2.7.1.21) |
C00000947
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000947
|
| 943 | TNFRSF8, CD30, D1S166E, Ki-1 | tumor necrosis factor receptor superfamily, member 8 |
C00000947
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00000947
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00000947
|
| 2829 | XCR1, CCXCR1, GPR5 | chemokine (C motif) receptor 1 |
C00000947
|
| 51042 | ZNF593, ZT86 | zinc finger protein 593 |
C00000947
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (58)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #608584 | Asthma-related traits, susceptibility to, 2 |
Q6W5P4
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #232300 | Glycogen storage disease ii |
P10253
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613839 | Megaloblastic anemia due to dihydrofolate reductase deficiency |
P00374
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
P24723 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (54)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P08581 (related) Q16790 (marker) |
| H01197 | Dihydrofolate reductase (DHFR) deficiency |
P00374
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q9NUW8 (related) |
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00018 | Gastric cancer |
P08581
(related)
P10415 (related) |
| H00046 | Cholangiocarcinoma |
P08581
(related)
P35354 (related) |
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P10415
(related)
P28907 (marker) |
| H00013 | Small cell lung cancer |
P10415
(related)
|
| H00028 | Choriocarcinoma |
P10415
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00041 | Kaposi's sarcoma |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
Q01453
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
13 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D050197 | Atherosclerosis |
C00000947
|
| D001943 | Breast Neoplasms |
C00000947
|
| D002471 | Cell Transformation, Neoplastic |
C00000947
|
| D003556 | Cystitis |
C00000947
|
| D056486 | Drug-Induced Liver Injury |
C00000947
|
| D034381 | Hearing Loss |
C00000947
|
| D006331 | Heart Diseases |
C00000947
|
| D020138 | HYPERHOMOCYSTEINEMIA |
C00000947
|
| D008107 | Liver Diseases |
C00000947
|
| D017114 | Liver Failure, Acute |
C00000947
|
| D008113 | Liver Neoplasms |
C00000947
|
| D008325 | Mammary Neoplasms, Experimental |
C00000947
|
| D009362 | Neoplasm Metastasis |
C00000947
|