PCIDB

KNApSAcK Metabolite C00000957

Metabolite

KNApSAcK Entry

id C00000957
Name (+)-Epicatechin / ent-Epicatechin
CAS RN 35323-91-2
Standard InChI InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15-/m0/s1
Standard InChI (Main Layer) InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2

Cluster

Phytochemical cluster No. 14
KCF-S cluster No. 52

Link

ChEMBL

By standard InChI CHEMBL129482
By standard InChI Main Layer CHEMBL80941 CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912

KEGG

By LinkDB C09728

CTD

By CAS RN

Human Protein / Gene in interaction

85 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL583912 CHEMBL1741321 (3)
1 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL311498 CHEMBL1908082 (1)
3 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr CHEMBL311498 CHEMBL980220 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL311498 CHEMBL1613842 (1)
4 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL583912 CHEMBL1738312 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL583912 CHEMBL1020816 (1) CHEMBL995707 (4)
CHEMBL1008495 (1)
0 / 3
Q13093 Platelet-activating factor acetylhydrolase Enzyme CHEMBL206452 CHEMBL583912 CHEMBL1032505 (2)
3 / 0
P06746 DNA polymerase beta Enzyme CHEMBL311498 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL583912 CHEMBL1614076 (1)
1 / 1
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase CHEMBL206452 CHEMBL1227478 (1)
0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase CHEMBL206452 CHEMBL1227477 (1)
0 / 0
P43166 Carbonic anhydrase 7 Lyase CHEMBL206452 CHEMBL1227480 (1)
0 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme CHEMBL200715 CHEMBL583912 CHEMBL921930 (2)
0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase CHEMBL206452 CHEMBL1227626 (1)
0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme CHEMBL206452 CHEMBL1799589 (1)
0 / 1
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL583912 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL311498 CHEMBL583912 CHEMBL822904 (1) CHEMBL1023248 (2)
1 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL206452 CHEMBL1227474 (1)
1 / 2
P02768 Serum albumin Secreted protein CHEMBL583912 CHEMBL1177441 (1)
0 / 0
P49327 Fatty acid synthase Transferase CHEMBL129482 CHEMBL583912 CHEMBL862461 (1) CHEMBL862462 (1)
CHEMBL1260143 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL583912 CHEMBL1741325 (3)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL311498 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL311498 CHEMBL1014691 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL206452 CHEMBL1794311 (1)
2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL311498 CHEMBL1020815 (1) CHEMBL1008496 (1)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL926465 (3)
0 / 0
P23280 Carbonic anhydrase 6 Lyase CHEMBL206452 CHEMBL1227479 (1)
0 / 0
Q9Y3R4 Sialidase-2 Enzyme CHEMBL200715 CHEMBL1100507 (1)
0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase CHEMBL206452 CHEMBL1227627 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL311498 CHEMBL206452 CHEMBL1614458 (2)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL206452 CHEMBL1227625 (1)
1 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL311498 CHEMBL1613922 (1) CHEMBL1794486 (1)
0 / 0
P07998 Ribonuclease pancreatic Enzyme CHEMBL206452 CHEMBL583912 CHEMBL1225513 (2)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL583912 CHEMBL1794584 (1)
2 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL926467 (3)
0 / 0
P00915 Carbonic anhydrase 1 Lyase CHEMBL206452 CHEMBL1227473 (1)
0 / 0
P07711 Cathepsin L1 C1A CHEMBL583912 CHEMBL1614088 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL311498 CHEMBL1794569 (1)
1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL583912 CHEMBL1738315 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL583912 CHEMBL1738602 (1)
3 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL206452 CHEMBL1794467 (1)
0 / 0
P00734 Prothrombin S1A CHEMBL311498 CHEMBL976587 (1)
4 / 2
P04745 Alpha-amylase 1 Enzyme CHEMBL206452 CHEMBL583912 CHEMBL964479 (4)
0 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily CHEMBL200715 CHEMBL583912 CHEMBL1056839 (2)
2 / 3
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL206452 CHEMBL1614521 (1)
0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL583912 CHEMBL1738514 (1)
0 / 1
P56817 Beta-secretase 1 A1A CHEMBL129482 CHEMBL653507 (2)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL583912 CHEMBL1741322 (3)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL206452 CHEMBL1228226 (1)
0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL311498 CHEMBL583912 CHEMBL1614227 (3)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL206452 CHEMBL1614038 (1)
2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL311498 CHEMBL1614171 (1)
5 / 2
P00374 Dihydrofolate reductase Oxidoreductase CHEMBL583912 CHEMBL930269 (1)
1 / 1
P35372 Mu-type opioid receptor Opioid receptor CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL926466 (3)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL583912 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL206452 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL583912 CHEMBL1741323 (3)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL583912 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (3)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL311498 CHEMBL583912 CHEMBL1794483 (2)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL311498 CHEMBL1614052 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL311498 CHEMBL206452 CHEMBL583912 CHEMBL1614283 (1) CHEMBL1614466 (1)
CHEMBL1614211 (5)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL206452 CHEMBL1908080 (1)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL311498 CHEMBL206452 CHEMBL1614250 (2) CHEMBL1614421 (2)
CHEMBL1614502 (2)
4 / 3
P07451 Carbonic anhydrase 3 Lyase CHEMBL206452 CHEMBL1227475 (1)
0 / 0
P22748 Carbonic anhydrase 4 Lyase CHEMBL206452 CHEMBL1227476 (1)
1 / 1
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein CHEMBL206452 CHEMBL583912 CHEMBL937576 (2)
0 / 7
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL311498 CHEMBL206452 CHEMBL583912 CHEMBL1794536 (5)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL311498 CHEMBL206452 CHEMBL583912 CHEMBL1613914 (5)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL311498 CHEMBL206452 CHEMBL1613829 (2) CHEMBL1613928 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL311498 CHEMBL583912 CHEMBL1738442 (4)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL206452 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL206452 CHEMBL583912 CHEMBL1614257 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL206452 CHEMBL583912 CHEMBL1614257 (2)
1 / 3
Q05513 Protein kinase C zeta type Iota CHEMBL80941 CHEMBL769344 (1)
0 / 0
Q04759 Protein kinase C theta type Delta CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 1
Q02156 Protein kinase C epsilon type Eta CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P05129 Protein kinase C gamma type Alpha CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
1 / 1
P05771 Protein kinase C beta type Alpha CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
P24723 Protein kinase C eta type Eta CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
1 / 0
P41743 Protein kinase C iota type Iota CHEMBL80941 CHEMBL769344 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL80941 CHEMBL769344 (1) CHEMBL768505 (1)
0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein CHEMBL583912 CHEMBL2114881 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
#118300 Charcot-marie-tooth disease and deafness Q01453
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P08581
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#600852 Retinitis pigmentosa 17; rp17 P22748
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (54)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
P28907 (marker)
H00013 Small cell lung cancer P10415 (related)
H00028 Choriocarcinoma P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q01453 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)