Species

KNApSAcK Entry

Organism name Colophospermum mopane
Genus Colophospermum
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Colophospermum mopane
Linked NCBI taxonomy ID 162715
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (49)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005112 External link 512 Mopanin
/ Mopanine
/ 3,4,10-Trihydroxy-[2]benzopyrano[4,3-b][1]benzopyran-7(5H)-one
No. 3 No. 15
C00009164 External link 512 Fisetinidol-(4alpha->6')-peltogynan-4alpha-ol
No. 16 No. 19
C00009193 External link 512 ent-Epimopanane-(4alpha->6)-ent-epifisetinidol
No. 16 No. 19
C00009192 External link 512 Epimopanane-(4beta->6)-fisetinidol
No. 16 No. 19
C00009132 External link 512 Guibourtinidol-(4alpha->6')-fisetinidol
No. 16 No. 19
C00009191 External link 512 Mopanane-(4beta->6)-fisetinidol
No. 16 No. 19
C00009190 External link 512 ent-Epipeltogynane-(4alpha->6)-fisetinidol
No. 16 No. 19
C00009189 External link 512 Peltogynane-(4beta->6)-fisetinidol
No. 16 No. 19
C00008934 External link 512 6,7-Dihydro-6-(2,4-dihydroxyphenyl)-8-(3,4-dihydroxyphenyl)-7-hydroxy-8H-pyrano[3,2-g]fisetinidol
No. 16 No. 19
C00008935 External link 512 6,7-Dihydro-6-(2,4-dihydroxyphenyl)-8-(3,4-dihydroxyphenyl)-7-hydroxy-8H-pyrano[3,2-g]-ent-epifisetnidol
No. 16 No. 19
C00008936 External link 512 8,9-Dihydro-10-(2,4-dihydroxyphenyl)-8-(3,4-dihydroxyphenyl)-9-hydroxy-10H-pyrano[2,3-h]fisetinidol
No. 16 No. 19
C00008938 External link 512 8,9-Dihydro-10-(2,4-dihydroxyphenyl)-8-(3,4-dihydroxyphenyl)-9-hydroxy-10H-pyrano[2,3-h]-ent-epifisetinidol
No. 16 No. 19
C00008939 External link 512 4'-(2,4-Dihydroxyphenyl)-2'-(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro(2,6')-bis-2H-1-benzopyran3,3',7,8'-tetraol
No. 16 No. 19
C00008950 External link 512 (10S)-8,9-Dihydro-10-(2,4-dihydroxyphenyl)-8-(3,4-dihydroxyphenyl)-9-hydroxy-10H-pyrano[2,3-h]epicatechin
No. 16 No. 19
C00009145 External link 512 ent-Epifisetinidol-(4alpha->6)-fisetinidol
No. 16 No. 19
C00009144 External link 512 Fisetinidol-(4alpha->6)-ent-epifisetinidol
No. 16 No. 19
C00009194 External link 512 ent-Epimopanane-(4alpha->8)-fisetinidol
No. 16 No. 19
C00009138 External link 512 Fisetinidol-(4beta->8)-catechin
No. 16 No. 19
C00009161 External link 512 Fisetinidol-(4alpha->6')-fisetinidol
No. 16 No. 19
C00009143 External link 512 Fisetinidol-(4alpha->6)-fisetinidol
No. 16 No. 19
C00009126 External link 512 Guibourtinidol-(4alpha->8)-catechin
No. 16 No. 19
C00009129 External link 512 Guibourtinidol-(4alpha->6)-fisetinidol
No. 16 No. 19
C00009130 External link 512 Guibourtinidol-(4alpha->6)-ent-epifisetinidol
No. 16 No. 19
C00009131 External link 512 Guibourtinidol-(4alpha->8)-fisetinidol
No. 16 No. 19
C00009148 External link 512 Fisetinidol-(4alpha->8)-fisetinidol
No. 16 No. 19
C00009139 External link 512 Fisetinidol-(4alpha->8)-epicatechin
No. 16 No. 19
C00009134 External link 512 Fisetinidol-(4alpha->8)-afzelechin
No. 16 No. 19
C00009137 External link 512 Fisetinidol-(4alpha->8)-catechin
No. 16 No. 19
C00009162 External link 512 Fisetinidol-(4beta->6')-fisetinidol
No. 16 No. 19
C00009133 External link 512 Guibourtinidol-(4alpha->10)-[7,8-dihydro-8-(2,4-dihydroxyphenyl)-6-(3,4-dihydroxyphenyl)-7-hydroxy-6H-pyrano[2,3-f]catechin
No. 29 No. 19
C00009150 External link 512 Fisetinidol-(4alpha->8)-catechin-(6->4alpha)-fisetinidol
No. 29 No. 19
C00009165 External link 512 Fisetinidol-(4alpha->8)-[7,8-dihydro-8-(2,4-dihydroxyphenyl)-7-hydroxy-6-(4-hydroxyphenyl)-6H-pyrano[2,3-f]catechin]
No. 29 No. 19
C00008960 External link 512 8,12-Bis(2,4-dihydroxyphenyl)-6,10-bis(3,4-dihydroxyphenyl)-7,11-dihydroxy-7,8,11,12-tetrahydro-6H,10H-dipyrano[2,3-f:2',3'-h]catechin
No. 29 No. 19
C00000677 External link 512 Distylin
/ Dihydroquercetin
/ (2R,3R)-Taxifolin
CHEMBL66
CHEMBL9249
CHEMBL337309
CHEMBL1492383
C003377
65 / 41 / 37 29 / 1 No. 42 No. 14
C00009044 External link 512 Epimopanan-4alpha-ol
No. 52 No. 14
C00009043 External link 512 (+)-Mopanol
/ (+)-Mopanol A
/ Mopanan-4alpha-ol
No. 52 No. 14
C00009039 External link 512 Peltogynan-4-alpha-ol
No. 52 No. 14
C00008999 External link 512 ent-Epifisetinidol-4beta-ol
No. 52 No. 14
C00008996 External link 512 Fisetinidol-4alpha-ol
No. 52 No. 14
C00020655 External link 512 Mopanol B
No. 52 No. 14
C00008824 External link 512 ent-Epifisetinidol
CHEMBL1367159
10 / 7 / 7 No. 52 No. 14
C00000947 External link 512 D-Catechol
/ D-Catechin
/ Teafuran 30A
/ (+)-Catechin
/ Dexcyanidanol
/ (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
D002392
85 / 58 / 54 91 / 13 No. 52 No. 14
C00000962 External link 512 Mollisacacidin
/ Fisetinidol-4beta-ol
No. 52 No. 14
C00000956 External link 512 (-)-Epicatechin
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
85 / 58 / 54 No. 52 No. 14
C00008822 External link 512 Fisetinidol
CHEMBL1367159
10 / 7 / 7 No. 52 No. 14
C00044940 External link 512 Moponeol B
No. 70
C00044939 External link 512 Moponeol A
No. 70
C00009357 External link 512 Guibourtinidol
/ (2R,3S)-4',7-Dihydroxyflavan-3-ol
No. 179 No. 15
C00008926 External link 512 Fisetinidol-(3'-O-4')-ent-epimopanone
No. 5439

Human Protein / Gene in interactions

107 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UBT6 DNA polymerase kappa Enzyme C00000677 C00000947 C00000956 C00008822 C00008824 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000677 C00000947 C00000956 C00008822 C00008824 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000677 C00000947 C00000956 C00008822 C00008824 3 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000677 C00000947 C00000956 C00008822 C00008824 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000677 C00000947 C00000956 C00008822 C00008824 4 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000677 C00000947 C00000956 C00008822 C00008824 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000677 C00000947 C00000956 C00008822 C00008824 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000677 C00000947 C00000956 C00008822 C00008824 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000947 C00000956 C00008822 C00008824 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000677 C00000947 C00000956 1 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000677 C00000947 C00000956 0 / 0
P06746 DNA polymerase beta Enzyme C00000677 C00000947 C00000956 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000677 C00000947 C00000956 1 / 1
Q02156 Protein kinase C epsilon type Eta C00000677 C00000947 C00000956 0 / 0
Q04759 Protein kinase C theta type Delta C00000677 C00000947 C00000956 0 / 1
Q05513 Protein kinase C zeta type Iota C00000677 C00000947 C00000956 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000677 C00000947 C00000956 1 / 2
O00255 Menin Unclassified protein C00000677 C00000947 C00000956 2 / 5
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000677 C00000947 C00000956 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000677 C00000947 C00000956 0 / 0
Q05655 Protein kinase C delta type Delta C00000677 C00000947 C00000956 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00000677 C00000947 C00000956 0 / 1
P17252 Protein kinase C alpha type Alpha C00000677 C00000947 C00000956 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000677 C00000947 C00000956 1 / 1
P05129 Protein kinase C gamma type Alpha C00000677 C00000947 C00000956 1 / 1
P05771 Protein kinase C beta type Alpha C00000677 C00000947 C00000956 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000677 C00000947 C00000956 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000677 C00000947 C00000956 0 / 1
P54132 Bloom syndrome protein Enzyme C00000677 C00000947 C00000956 1 / 2
P24723 Protein kinase C eta type Eta C00000677 C00000947 C00000956 1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000677 C00000947 C00000956 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000677 C00000947 C00000956 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000677 C00000947 C00000956 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000677 C00000947 C00000956 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000677 C00000947 C00000956 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000677 C00000947 C00000956 5 / 2
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000677 C00000947 C00000956 2 / 2
Q16637 Survival motor neuron protein Unclassified protein C00000677 C00000947 C00000956 4 / 1
P41743 Protein kinase C iota type Iota C00000677 C00000947 C00000956 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000677 C00000947 C00000956 0 / 0
P56817 Beta-secretase 1 A1A C00000677 C00000947 C00000956 0 / 0
P39748 Flap endonuclease 1 Enzyme C00000677 C00000947 C00000956 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00000677 C00000947 C00000956 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000677 C00000947 C00000956 1 / 1
P41143 Delta-type opioid receptor Opioid receptor C00000677 C00000947 C00000956 0 / 0
P49327 Fatty acid synthase Transferase C00000947 C00000956 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000947 C00000956 0 / 0
P07711 Cathepsin L1 C1A C00000947 C00000956 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00000947 C00000956 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000947 C00000956 2 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00000947 C00000956 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000947 C00000956 3 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000947 C00000956 3 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000947 C00000956 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000947 C00000956 0 / 0
P00734 Prothrombin S1A C00000947 C00000956 4 / 2
P04745 Alpha-amylase 1 Enzyme C00000947 C00000956 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000947 C00000956 0 / 3
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000947 C00000956 3 / 0
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00000947 C00000956 2 / 3
P07998 Ribonuclease pancreatic Enzyme C00000947 C00000956 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000947 C00000956 3 / 2
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000947 C00000956 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000947 C00000956 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000947 C00000956 0 / 1
P43166 Carbonic anhydrase 7 Lyase C00000947 C00000956 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000947 C00000956 1 / 2
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00000947 C00000956 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000947 C00000956 0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme C00008822 C00008824 0 / 0
P00374 Dihydrofolate reductase Oxidoreductase C00000947 C00000956 1 / 1
Q9Y3R4 Sialidase-2 Enzyme C00000947 C00000956 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000947 C00000956 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000947 C00000956 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000947 C00000956 2 / 3
P11388 DNA topoisomerase 2-alpha Isomerase C00000947 C00000956 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000947 C00000956 1 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000947 C00000956 1 / 0
P02768 Serum albumin Secreted protein C00000947 C00000956 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000947 C00000956 5 / 1
P00918 Carbonic anhydrase 2 Lyase C00000947 C00000956 1 / 2
P07451 Carbonic anhydrase 3 Lyase C00000947 C00000956 0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00000947 C00000956 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000947 C00000956 1 / 1
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00000947 C00000956 0 / 7
P10696 Alkaline phosphatase, placental-like Enzyme C00000947 C00000956 0 / 1
P24298 Alanine aminotransferase 1 Enzyme C00000677 0 / 0
P08254 Stromelysin-1 M10A C00000677 1 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000677 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000677 2 / 2
O75496 Geminin Unclassified protein C00000677 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00000677 1 / 1
P39900 Macrophage metalloelastase M10A C00000677 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00000677 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00000677 1 / 4
P08253 72 kDa type IV collagenase M10A C00000677 1 / 3
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000677 1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000677 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000677 2 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000677 0 / 0
P45452 Collagenase 3 M10A C00000677 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00000677 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000677 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00000677 2 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein C00000677 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000677 0 / 0
P03956 Interstitial collagenase M10A C00000677 0 / 1

116 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000677 C00000947
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000677 C00000947
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000677 C00000947
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000677 C00000947
4869 NPM1, B23, NPM nucleophosmin (nucleolar phosphoprotein B23, numatrin) C00000947
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00000677
1630 DCC, CRC18, CRCR1, IGDCC1, MRMV1 deleted in colorectal carcinoma C00000677
1950 EGF, HOMG4, URG epidermal growth factor C00000677
8817 FGF18, FGF-18, ZFGF5 fibroblast growth factor 18 C00000677
2248 FGF3, HBGF-3, INT2 fibroblast growth factor 3 C00000677
2621 GAS6, AXLLG, AXSF growth arrest-specific 6 C00000677
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00000677
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00000677
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000677
8900 CCNA1 cyclin A1 C00000677
3458 IFNG, IFG, IFI interferon, gamma C00000677
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00000677
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000677
4547 MTTP, ABL, MTP microsomal triglyceride transfer protein C00000677
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00000677
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00000677
5155 PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis platelet-derived growth factor beta polypeptide C00000677
5921 RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP RAS p21 protein activator (GTPase activating protein) 1 C00000677
335 APOA1 apolipoprotein A-I C00000677
7187 TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1 TNF receptor-associated factor 3 C00000677
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000677
7498 XDH, XO, XOR xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) C00000677
7507 XPA, XP1, XPAC xeroderma pigmentosum, complementation group A C00000677
7518 XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 C00000677
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00000947
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000947
302 ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV annexin A2 C00000947
393 ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115 Rho GTPase activating protein 4 C00000947
468 ATF4, CREB-2, CREB2, TAXREB67, TXREB activating transcription factor 4 C00000947
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00000947
2683 B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) C00000947
56751 BARHL1 BarH-like homeobox 1 C00000947
581 BAX, BCL2L4 BCL2-associated X protein C00000947
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000947
637 BID, FP497 BH3 interacting domain death agonist C00000947
388962 BOLA3, MMDS2 bolA family member 3 C00000947
79184 BRCC3, BRCC36, C6.1A, CXorf53 BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) C00000947
694 BTG1 B-cell translocation gene 1, anti-proliferative C00000947
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000947
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00000947
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000947
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000947
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00000947
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000947
930 CD19, B4, CVID3 CD19 molecule C00000947
975 CD81, CVID6, S5.7, TAPA1, TSPAN28 CD81 molecule C00000947
928 CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 CD9 molecule C00000947
1054 CEBPG, GPE1BP, IG/EBP-1 CCAAT/enhancer binding protein (C/EBP), gamma C00000947
10978 CLP1, HEAB, hClp1 cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) C00000947
10063 COX17 COX17 cytochrome c oxidase copper chaperone C00000947
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00000947
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00000947
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000947
7913 DEK, D6S231E DEK oncogene C00000947
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00000947
2130 EWSR1, EWS, bK984G1.4 EWS RNA-binding protein 1 C00000947
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000947
2323 FLT3LG, FL, FLT3L fms-related tyrosine kinase 3 ligand C00000947
2495 FTH1, FHC, FTH, FTHL6, PIG15, PLIF ferritin, heavy polypeptide 1 (EC:1.16.3.1) C00000947
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00000947
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00000947
3054 HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, VCAF host cell factor C1 (VP16-accessory protein) C00000947
3232 HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1 homeobox D3 C00000947
3329 HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 heat shock 60kDa protein 1 (chaperonin) C00000947
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00000947
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000947
3559 IL2RA, CD25, IDDM10, IL2R, TCGFR interleukin 2 receptor, alpha C00000947
9235 IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd interleukin 32 C00000947
3662 IRF4, LSIRF, MUM1, NF-EM5 interferon regulatory factor 4 C00000947
3683 ITGAL, CD11A, LFA-1, LFA1A integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) C00000947
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00000947
4067 LYN, JTK8, p53Lyn, p56Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) C00000947
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00000947
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00000947
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000947
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000947
4282 MIF, GIF, GLIF, MMIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) C00000947
64975 MRPL41, BMRP, MRP-L27, MRPL27, RPML27 mitochondrial ribosomal protein L41 C00000947
4493 MT1E, MT1, MTD metallothionein 1E C00000947
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00000947
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000947
4851 NOTCH1, TAN1, hN1 notch 1 C00000947
993 CDC25A, CDC25A2 cell division cycle 25A (EC:3.1.3.48) C00000677
5175 PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM platelet/endothelial cell adhesion molecule 1 C00000947
5187 PER1, PER, RIGUI, hPER period circadian clock 1 C00000947
5327 PLAT, T-PA, TPA plasminogen activator, tissue (EC:3.4.21.68) C00000947
5328 PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA plasminogen activator, urokinase (EC:3.4.21.73) C00000947
7916 PRRC2A, BAT2, D6S51, D6S51E, G2 proline-rich coiled-coil 2A C00000947
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000947
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00000947
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00000947
5915 RARB, HAP, NR1B2, RRB2 retinoic acid receptor, beta C00000947
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000947
6128 RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 ribosomal protein L6 C00000947
6285 S100B, NEF, S100, S100-B, S100beta S100 calcium binding protein B C00000947
6286 S100P, MIG9 S100 calcium binding protein P C00000947
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00000947
7536 SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 splicing factor 1 C00000947
6574 SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1 solute carrier family 20 (phosphate transporter), member 1 C00000947
6699 SPRR1B, CORNIFIN, GADD33, SPRR1 small proline-rich protein 1B C00000947
6777 STAT5B, STAT5 signal transducer and activator of transcription 5B C00000947
6778 STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C signal transducer and activator of transcription 6, interleukin-4 induced C00000947
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000947
6932 TCF7, TCF-1 transcription factor 7 (T-cell specific, HMG-box) C00000947
7083 TK1, TK2 thymidine kinase 1, soluble (EC:2.7.1.21) C00000947
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000947
943 TNFRSF8, CD30, D1S166E, Ki-1 tumor necrosis factor receptor superfamily, member 8 C00000947
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00000947
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00000947
2829 XCR1, CCXCR1, GPR5 chemokine (C motif) receptor 1 C00000947
51042 ZNF593, ZT86 zinc finger protein 593 C00000947

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (69)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
#118300 Charcot-marie-tooth disease and deafness Q01453
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
P84022
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#133239 Esophageal cancer P18054
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
P22310
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#114550 Hepatocellular carcinoma P08581
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#601626 Leukemia, acute myeloid; aml P36888
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (59)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P08581 (related)
Q16790 (marker)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
P10415 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00018 Gastric cancer P08581 (related)
P10415 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
P28907 (marker)
H00013 Small cell lung cancer P10415 (related)
H00030 Cervical cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q01453 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

14 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006461 Hemolysis C00000677
D050197 Atherosclerosis C00000947
D001943 Breast Neoplasms C00000947
D002471 Cell Transformation, Neoplastic C00000947
D003556 Cystitis C00000947
D056486 Drug-Induced Liver Injury C00000947
D034381 Hearing Loss C00000947
D006331 Heart Diseases C00000947
D020138 HYPERHOMOCYSTEINEMIA C00000947
D008107 Liver Diseases C00000947
D017114 Liver Failure, Acute C00000947
D008113 Liver Neoplasms C00000947
D008325 Mammary Neoplasms, Experimental C00000947
D009362 Neoplasm Metastasis C00000947