Hypericum perforatum L.
Species
KNApSAcK Entry
| Organism name | Hypericum perforatum L. |
|---|---|
| Genus | Hypericum |
| Family | Hypericaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Hypericum perforatum |
|---|---|
| Linked NCBI taxonomy ID | 65561 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Hypericaceae |
|---|---|
| ID | 629714 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (43)
| Species | Activity |
|---|---|
| Hypericum perforatum L. | Analgesic |
| Hypericum perforatum L. | Antibacterial |
| Hypericum perforatum L. | Anticancer |
| Hypericum perforatum L. | Antidepressant |
| Hypericum perforatum L. | Antidote |
| Hypericum perforatum L. | Antiedemic |
| Hypericum perforatum L. | Antiherpetic |
| Hypericum perforatum L. | Antiinflammatory |
| Hypericum perforatum L. | Antineuralgic |
| Hypericum perforatum L. | Antiretroviral |
| Hypericum perforatum L. | Antiseptic |
| Hypericum perforatum L. | Antispasmodic |
| Hypericum perforatum L. | Antiulcerogenic |
| Hypericum perforatum L. | Antiviral |
| Hypericum perforatum L. | Anxiolytic |
| Hypericum perforatum L. | Aperitif |
| Hypericum perforatum L. | Astringent |
| Hypericum perforatum L. | Basoconstrictor |
| Hypericum perforatum L. | Cholagogue |
| Hypericum perforatum L. | COMT Inhibitor |
| Hypericum perforatum L. | Digestive |
| Hypericum perforatum L. | Diuretic |
| Hypericum perforatum L. | Dopaminergic |
| Hypericum perforatum L. | Emmenagogue |
| Hypericum perforatum L. | Expectorant |
| Hypericum perforatum L. | GABA-Reuptake Inhibitor |
| Hypericum perforatum L. | Hemostat |
| Hypericum perforatum L. | Hypotensive |
| Hypericum perforatum L. | Immunostimulant |
| Hypericum perforatum L. | MAOI |
| Hypericum perforatum L. | Melatoninergic |
| Hypericum perforatum L. | Nervine |
| Hypericum perforatum L. | Psychotropic |
| Hypericum perforatum L. | Resolvent |
| Hypericum perforatum L. | Sedative |
| Hypericum perforatum L. | Serotoninergic |
| Hypericum perforatum L. | SSRI |
| Hypericum perforatum L. | Stimulant |
| Hypericum perforatum L. | Tonic |
| Hypericum perforatum L. | Tranquilizer |
| Hypericum perforatum L. | Uterotonic |
| Hypericum perforatum L. | Vermifuge |
| Hypericum perforatum L. | Vulnerary |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005373
|
Hirsutrin
/ Isoquercetin / Isoquercetrin / (-)-Isoquercetrin / Quercetin 3-glucoside / Quercetin 3-O-beta-D-glucoside / Quercetin-3-O-beta-D-glucopyranoside / Quercetin 3-O-beta-D-glucopyranoside / (-)-Quercetin-3-O-beta-D-glucopyranoside |
CHEMBL33027
CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 |
38 / 43 / 34 | No. 2 | No. 15 |
|
||
|
C00030348
|
Normangostin
/ gamma-Mangostin |
CHEMBL260553
|
C102777
|
5 / 2 / 5 | No. 14 | No. 15 |
|
|
|
C00034758
|
1,3,7-Trihydroxy-6-methoxy-8-prenylxanthone
|
No. 15 | No. 15 |
|
||||
|
C00002968
|
Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene |
CHEMBL187265
|
C069053
|
9 / 10 / 7 | 4 / 0 | No. 71 | No. 15 |
|
Human Protein / Gene in interactions
50 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00005373 C00030348 | 0 / 3 |
| P49327 | Fatty acid synthase | Transferase | C00002968 C00030348 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005373 | 1 / 1 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00005373 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00005373 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00005373 | 6 / 4 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005373 | 1 / 1 |
| P39900 | Macrophage metalloelastase | M10A | C00002968 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002968 | 2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00005373 | 11 / 10 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00005373 | 1 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002968 | 1 / 1 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00005373 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00005373 | 4 / 1 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005373 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005373 | 1 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00030348 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00005373 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00005373 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005373 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00005373 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00005373 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00005373 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002968 | 0 / 1 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00030348 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005373 | 0 / 0 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005373 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005373 | 3 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00030348 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00005373 | 4 / 2 |
| P06280 | Alpha-galactosidase A | Enzyme | C00005373 | 1 / 1 |
| P45452 | Collagenase 3 | M10A | C00002968 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00005373 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005373 | 0 / 1 |
| P08253 | 72 kDa type IV collagenase | M10A | C00002968 | 1 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00005373 | 2 / 0 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002968 | 4 / 2 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00005373 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005373 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005373 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00005373 | 4 / 3 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00005373 | 1 / 0 |
| P08254 | Stromelysin-1 | M10A | C00002968 | 1 / 0 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005373 | 1 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005373 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00005373 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00005373 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00005373 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00005373 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005373 | 0 / 0 |
4 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002968
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00002968
|
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00002968
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002968
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (55)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
| #601367 | Stroke, ischemic |
P12821
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (42)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00192 | Xanthinuria |
P47989
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|