PCIDB

KNApSAcK Metabolite C00002968

Metabolite

KNApSAcK Entry

id C00002968
Name Norathyriol / 1,3,6,7-Tetrahydroxyxanthoene
CAS RN 3542-72-1
Standard InChI InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H
Standard InChI (Main Layer) InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 71

Link

ChEMBL

By standard InChI CHEMBL187265
By standard InChI Main Layer CHEMBL187265

KEGG

By LinkDB C10086

CTD

By CAS RN C069053

Species

Summary

Plant class

class name count
rosids 26
asterids 2
Liliopsida 1
Euphyllophyta 1

Family

family name count
Clusiaceae 11
Hypericaceae 8
Moraceae 5
Gentianaceae 2
Calophyllaceae 2
Iridaceae 1
Athyriaceae 1

List (37)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Allanblackia floribunda 469914 Clusiaceae rosids Viridiplantae
Allanblackia spp. 469913 Clusiaceae rosids Viridiplantae
Athyrium mesosorum 32109 Athyriaceae Euphyllophyta Viridiplantae
Canscora decussata 82702 Gentianaceae asterids Viridiplantae
Chlorophora spp. 3487 Moraceae rosids Viridiplantae
Chlorophora tinctoria 3487 Moraceae rosids Viridiplantae
Clarisa spp.
Clarisia racemosa R.et P. 241873 Moraceae rosids Viridiplantae
Cratoxylum formosum ssp.pruniflorum 198760 Hypericaceae rosids Viridiplantae
Cratoxylum prumiflorum 198760 Hypericaceae rosids Viridiplantae
Cratoxylum pruniflorum 1137046 Hypericaceae rosids Viridiplantae
Garcinia cowa 180103 Clusiaceae rosids Viridiplantae
Garcinia echinocarpa 58227 Clusiaceae rosids Viridiplantae
Garcinia griffithii 180106 Clusiaceae rosids Viridiplantae
Garcinia mangostana 58228 Clusiaceae rosids Viridiplantae
Garcinia multiflora 1009474 Clusiaceae rosids Viridiplantae
Garcinia pedunculata 1220708 Clusiaceae rosids Viridiplantae
Garcinia polyantha Oliv. 58227 Clusiaceae rosids Viridiplantae
Garcinia terpnophylla 58227 Clusiaceae rosids Viridiplantae
Hypericum androsaemum 140968 Hypericaceae rosids Viridiplantae
Hypericum aucheri 1321321 Hypericaceae rosids Viridiplantae
Hypericum chinense 55962 Hypericaceae rosids Viridiplantae
Hypericum perforatum L. 65561 Hypericaceae rosids Viridiplantae
Hypericum sampsonii 282553 Hypericaceae rosids Viridiplantae
Iris nigricans 995810 Iridaceae Liliopsida Viridiplantae
Maclura pomifera 3496 Moraceae rosids Viridiplantae
Mammea africana 999584 Calophyllaceae rosids Viridiplantae
Mammea spp. 180118 Calophyllaceae rosids Viridiplantae
Morus tinctoria 3487 Moraceae rosids Viridiplantae
Ochrocapus odoratus
Ochrocarpus odoratus
Ochrocarpus spp.
Pentaphalangium solomonse
Symphonia globulifera 156483 Clusiaceae rosids Viridiplantae
Symphonia spp.
Syphonia globifera
Tripterospermum taiwanense 933385 Gentianaceae asterids Viridiplantae

Human Protein / Gene in interaction

9 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P39900 Macrophage metalloelastase M10A CHEMBL187265 CHEMBL2051216 (1)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL187265 CHEMBL2051215 (1)
2 / 2
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL187265 CHEMBL827909 (1)
1 / 1
P49327 Fatty acid synthase Transferase CHEMBL187265 CHEMBL1260142 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL187265 CHEMBL2051212 (1) CHEMBL2051218 (1)
0 / 1
P45452 Collagenase 3 M10A CHEMBL187265 CHEMBL2051217 (1)
1 / 1
P08253 72 kDa type IV collagenase M10A CHEMBL187265 CHEMBL2051213 (1)
1 / 3
P12821 Angiotensin-converting enzyme M2 CHEMBL187265 CHEMBL964320 (1) CHEMBL964321 (1)
CHEMBL964322 (1) CHEMBL964323 (1)
CHEMBL964324 (1)
4 / 2
P08254 Stromelysin-1 M10A CHEMBL187265 CHEMBL2051214 (1)
1 / 0

CTD interaction (4)

compound gene gene name gene description interaction interaction type form reference
pmid
C069053 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) norathyriol results in increased expression of ABCB1 protein increases expression
protein 20513373
C069053 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha norathyriol inhibits the reaction [GW 7647 results in increased activity of PPARA protein] decreases reaction
/ increases activity
protein 18393431
C069053 5467 PPARD
FAAR
NR1C2
NUC1
NUCI
NUCII
PPARB
peroxisome proliferator-activated receptor delta norathyriol inhibits the reaction [GW0742 results in increased activity of PPARD protein] decreases reaction
/ increases activity
protein 18393431
C069053 5468 PPARG
CIMT1
GLM1
NR1C3
PPARG1
PPARG2
PPARgamma
peroxisome proliferator-activated receptor gamma norathyriol inhibits the reaction [ciglitazone results in increased activity of PPARG protein] decreases reaction
/ increases activity
protein 18393431

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#300615 Brunner syndrome P21397
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#267430 Renal tubular dysgenesis; rtd P12821
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P12821

KEGG DISEASE (7)

KEGG disease name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00548 Brunner syndrome P21397 (related)