Garcinia cowa
Species
KNApSAcK Entry
| Organism name | Garcinia cowa |
|---|---|
| Genus | Garcinia |
| Family | Clusiaceae / Clusiaceae-Guttiferae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Garcinia cowa |
|---|---|
| Linked NCBI taxonomy ID | 180103 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Clusiaceae |
|---|---|
| ID | 55961 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (26)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00029358
|
1,3,5-Trihydroxy-6-methoxyxanthone
|
No. 3 | No. 15 |
|
||||
|
C00030726
|
Mangostinone
|
CHEMBL481310
|
1 / 2 / 2 | No. 14 | No. 15 |
|
||
|
C00002963
|
Mangostin
/ alpha-Mangostin |
CHEMBL323197
|
C021053
|
25 / 27 / 58 | 0 / 3 | No. 14 | No. 15 |
|
|
C00035277
|
Cowagarcinone A
|
No. 14 | No. 15 |
|
||||
|
C00029819
|
beta-Mangostin
|
CHEMBL261706
|
3 / 0 / 0 | No. 14 | No. 15 |
|
||
|
C00034845
|
Fuscaxanthone C
|
CHEMBL464524
|
1 / 0 / 0 | No. 14 | No. 15 |
|
||
|
C00034828
|
Cowaxanthone E
|
No. 14 | No. 15 |
|
||||
|
C00035280
|
Cowagarcinone E
|
No. 14 | No. 15 |
|
||||
|
C00030834
|
Norcowanin
|
CHEMBL463409
|
No. 14 | No. 15 |
|
|||
|
C00031249
|
Rubraxanthone
|
CHEMBL458846
|
C472155
|
No. 14 | No. 15 |
|
||
|
C00034825
|
Cowaxanthone B
|
No. 14 | No. 15 |
|
||||
|
C00034823
|
Cowaxanthone
|
CHEMBL517161
|
No. 14 | No. 15 |
|
|||
|
C00034778
|
7-O-Methylgarcinone E
|
CHEMBL463410
|
No. 14 | No. 15 |
|
|||
|
C00034822
|
Cowanol
|
CHEMBL463408
|
No. 14 | No. 15 |
|
|||
|
C00034821
|
Cowanin
|
CHEMBL458845
|
No. 14 | No. 15 |
|
|||
|
C00035278
|
Cowaxanthone A
/ Cowagarcinone C |
No. 15 | No. 15 |
|
||||
|
C00034824
|
Cowaxanthone A
|
No. 15 | No. 15 |
|
||||
|
C00034759
|
Cowagarcinone B
/ 1,6-Dihydroxy-3,7-dimethoxy-2-(3-methyl-2-butenyl)xanthone |
No. 15 | No. 15 |
|
||||
|
C00030161
|
Dulxanthone A
|
No. 15 | No. 15 |
|
||||
|
C00034827
|
Cowaxanthone D
/ Dulcisxanthone F |
No. 18 | No. 15 |
|
||||
|
C00034826
|
Cowaxanthone C
|
No. 44 |
|
|||||
|
C00035279
|
Cowagarcinone D
|
No. 44 |
|
|||||
|
C00034776
|
6-O-Methylmangostanin
/ (+)-6-O-Methylmangostanin |
No. 47 | No. 15 |
|
||||
|
C00030721
|
Mangostanin
/ (-)-Mangostanin |
CHEMBL1080698
|
2 / 0 / 0 | No. 47 | No. 15 |
|
||
|
C00002968
|
Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene |
CHEMBL187265
|
C069053
|
9 / 10 / 7 | 4 / 0 | No. 71 | No. 15 |
|
|
C00029364
|
Euxanthone
/ 1,7-Dihydroxyxanthone |
CHEMBL389166
|
C404221
|
1 / 0 / 0 | No. 76 | No. 15 |
|
Human Protein / Gene in interactions
34 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q04206 | Transcription factor p65 | Transcription Factor | C00002963 C00029819 C00030721 C00034845 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00002963 C00029819 C00030721 | 0 / 0 |
| P49327 | Fatty acid synthase | Transferase | C00002963 C00002968 C00029819 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00002963 C00030726 | 2 / 2 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002963 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002963 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002968 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002963 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002963 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002963 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002963 | 2 / 2 |
| P03956 | Interstitial collagenase | M10A | C00002968 | 0 / 1 |
| P39900 | Macrophage metalloelastase | M10A | C00002968 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002963 | 7 / 37 |
| O60906 | Sphingomyelin phosphodiesterase 2 | Enzyme | C00002963 | 0 / 0 |
| P45452 | Collagenase 3 | M10A | C00002968 | 1 / 1 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002963 | 2 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002968 | 2 / 2 |
| P08253 | 72 kDa type IV collagenase | M10A | C00002968 | 1 / 3 |
| Q00987 | E3 ubiquitin-protein ligase Mdm2 | Other nuclear protein | C00002963 | 1 / 5 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002963 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002963 | 2 / 2 |
| O14763 | Tumor necrosis factor receptor superfamily member 10B | Unclassified protein | C00002963 | 1 / 0 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002968 | 4 / 2 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00029364 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002963 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002963 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002963 | 0 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002963 | 4 / 3 |
| P08254 | Stromelysin-1 | M10A | C00002968 | 1 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002963 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002963 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00002963 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002963 | 1 / 2 |
4 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002968
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00002968
|
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00002968
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002968
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (37)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #614401 | Accelerated tumor formation, susceptibility to; actfs |
Q00987
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #300615 | Brunner syndrome |
P21397
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
O14763
P04637 |
| #601367 | Stroke, ischemic |
P12821
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (63)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00028 | Choriocarcinoma |
P03956
(related)
P04637 (related) P08253 (related) Q00987 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P14780 (related) Q00987 (related) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) Q00987 (related) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) Q00987 (related) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00037 | Alveolar rhabdomyosarcoma |
Q00987
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|