Species

KNApSAcK Entry

Organism name Canscora decussata
Genus Canscora
Family Gentianaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Canscora
Linked NCBI taxonomy ID 82702
Linked level genus

Family

Family in NCBI taxonomy Gentianaceae
ID 21472

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002948 External link 512 1,6-Dihydroxy-3,5-dimethoxyxanthone
/ 3,5-Dimethoxy-1,6-dihydroxyxanthone
No. 3 No. 15
C00002966 External link 512 Swertiaperennin
/ Methylswertianin
/ 1,8-Dihydroxy-3,7-dimethoxyxanthone
No. 3 No. 15
C00037329 External link 512 Isogentiakochianin
/ 1,3,8-Trihydroxy-7-methoxyxanthone
No. 3 No. 15
C00037010 External link 512 Decussatin
/ 1-Hydroxy-3,7,8-trimethoxyxanthone
CHEMBL26323
1 / 1 / 1 No. 3 No. 15
C00036434 External link 512 1-Hydroxy-3,5,6-trimethoxyxanthone
No. 3 No. 15
C00029358 External link 512 1,3,5-Trihydroxy-6-methoxyxanthone
No. 3 No. 15
C00034990 External link 512 1,3,7-Trihydroxy-5,6-dimethoxyxanthone
No. 3 No. 15
C00032637 External link 512 3,5-Dihydroxy-1-methoxyxanthone
No. 3 No. 15
C00032586 External link 512 1,3,6-Trihydroxy-5-methoxyxanthone
No. 3 No. 15
C00002968 External link 512 Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene
CHEMBL187265
C069053
9 / 10 / 7 4 / 0 No. 71 No. 15
C00002970 External link 512 Norswertianin
/ 1,3,7,8-Tetrahydroxanthone
CHEMBL187043
1 / 1 / 1 No. 71 No. 15
C00019144 External link 512 Loliolide
/ (-)-Loliolide
CHEMBL227113
CHEMBL446471
C030425
1 / 2 / 2 No. 2667

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002968 C00002970 C00037010 1 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00019144 2 / 2
P39900 Macrophage metalloelastase M10A C00002968 0 / 0
P49327 Fatty acid synthase Transferase C00002968 0 / 0
P03956 Interstitial collagenase M10A C00002968 0 / 1
P14780 Matrix metalloproteinase-9 M10A C00002968 2 / 2
P45452 Collagenase 3 M10A C00002968 1 / 1
P08253 72 kDa type IV collagenase M10A C00002968 1 / 3
P12821 Angiotensin-converting enzyme M2 C00002968 4 / 2
P08254 Stromelysin-1 M10A C00002968 1 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002968
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002968
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00002968
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002968

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#300615 Brunner syndrome P21397
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#267430 Renal tubular dysgenesis; rtd P12821
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P12821

KEGG DISEASE (9)

KEGG name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00548 Brunner syndrome P21397 (related)