Species

KNApSAcK Entry

Organism name Symphonia globulifera
Genus Symphonia
Family Clusiaceae-Guttiferae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Symphonia globulifera
Linked NCBI taxonomy ID 156483
Linked level species

Family

Family in NCBI taxonomy Clusiaceae
ID 55961

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (10)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00037184 External link 512 Globulixanthone D
No. 15 No. 15
C00037969 External link 512 Ugaxanthone
No. 15 No. 15
C00044781 External link 512 Globulixanthone A
CHEMBL464342
No. 15 No. 15
C00044782 External link 512 Globulixanthone B
/ (+)-Globulixanthone B
CHEMBL464752
No. 18 No. 15
C00042227 External link 512 Ananixanthone
CHEMBL460547
No. 18 No. 15
C00037183 External link 512 Globulixanthone C
No. 24 No. 15
C00037185 External link 512 Globulixanthone E
No. 34 No. 18
C00031484 External link 512 1,3,5,6-Tetrahydroxyxanthone
CHEMBL448040
1 / 4 / 2 No. 71 No. 15
C00002968 External link 512 Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene
CHEMBL187265
C069053
9 / 10 / 7 4 / 0 No. 71 No. 15
C00037874 External link 512 Symphoxanthone
No. 425 No. 15

Human Protein / Gene in interactions

9 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P12821 Angiotensin-converting enzyme M2 C00002968 C00031484 4 / 2
P03956 Interstitial collagenase M10A C00002968 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002968 1 / 1
P49327 Fatty acid synthase Transferase C00002968 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002968 2 / 2
P45452 Collagenase 3 M10A C00002968 1 / 1
P08253 72 kDa type IV collagenase M10A C00002968 1 / 3
P39900 Macrophage metalloelastase M10A C00002968 0 / 0
P08254 Stromelysin-1 M10A C00002968 1 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002968
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002968
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00002968
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002968

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#300615 Brunner syndrome P21397
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#267430 Renal tubular dysgenesis; rtd P12821
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P12821

KEGG DISEASE (7)

KEGG name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00548 Brunner syndrome P21397 (related)