Species

KNApSAcK Entry

Organism name Garcinia griffithii
Genus Garcinia
Family Clusiaceae / Clusiaceae-Guttiferae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Garcinia griffithii
Linked NCBI taxonomy ID 180106
Linked level species

Family

Family in NCBI taxonomy Clusiaceae
ID 55961

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00048250 External link 512 1,5-Dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone
No. 14 No. 15
C00031484 External link 512 1,3,5,6-Tetrahydroxyxanthone
CHEMBL448040
1 / 4 / 2 No. 71 No. 15
C00002968 External link 512 Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene
CHEMBL187265
C069053
9 / 10 / 7 4 / 0 No. 71 No. 15
C00029364 External link 512 Euxanthone
/ 1,7-Dihydroxyxanthone
CHEMBL389166
C404221
1 / 0 / 0 No. 76 No. 15
C00031487 External link 512 1,6-Dihydroxyxanthone
CHEMBL459695
No. 76 No. 15
C00031902 External link 512 Cambogin
/ Isogarcinol
CHEMBL458934
CHEMBL1077027
CHEMBL1098255
CHEMBL2087611
2 / 1 / 1 No. 123
C00035323 External link 512 Guttiferone I
No. 123
C00019308 External link 512 Doursterol
/ Daucosterin
/ 3-O-beta-D-Glucopyranosyl sitosterol
/ beta-Sitosterol 3-O-beta-D-glucopyranoside
CHEMBL197711
CHEMBL506678
CHEMBL2304043
C011015
5 / 4 / 2 0 / 3 No. 520
C00035833 External link 512 Griffipavixanthone
No. 5544

Human Protein / Gene in interactions

17 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P12821 Angiotensin-converting enzyme M2 C00002968 C00031484 4 / 2
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002968 1 / 1
Q09472 Histone acetyltransferase p300 Enzyme C00031902 1 / 1
Q92831 Histone acetyltransferase KAT2B Enzyme C00031902 0 / 0
P06746 DNA polymerase beta Enzyme C00019308 0 / 0
P39900 Macrophage metalloelastase M10A C00002968 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002968 2 / 2
P08047 Transcription factor Sp1 Unclassified protein C00019308 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019308 0 / 0
P49327 Fatty acid synthase Transferase C00002968 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019308 0 / 0
P03956 Interstitial collagenase M10A C00002968 0 / 1
P00734 Prothrombin S1A C00019308 4 / 2
P45452 Collagenase 3 M10A C00002968 1 / 1
P08253 72 kDa type IV collagenase M10A C00002968 1 / 3
P35610 Sterol O-acyltransferase 1 Enzyme C00029364 0 / 0
P08254 Stromelysin-1 M10A C00002968 1 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002968
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002968
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00002968
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002968

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#300615 Brunner syndrome P21397
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#267430 Renal tubular dysgenesis; rtd P12821
#613684 Rubinstein-taybi syndrome 2; rsts2 Q09472
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P00734
P12821
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (10)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00548 Brunner syndrome P21397 (related)
H00504 Rubinstein-Taybi syndrome Q09472 (related)

Diseases related to CTD interactions

3 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D002493 Central Nervous System Diseases C00019308
D003072 Cognition Disorders C00019308
D013118 Spinal Cord Diseases C00019308