Garcinia multiflora
Species
KNApSAcK Entry
| Organism name | Garcinia multiflora |
|---|---|
| Genus | Garcinia |
| Family | Clusiaceae / Clusiaceae-Guttiferae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Garcinia multiflora |
|---|---|
| Linked NCBI taxonomy ID | 1009474 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Clusiaceae |
|---|---|
| ID | 55961 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Metabolite list (27)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000982
|
Naringenin
/ (-)-Naringenin |
CHEMBL9352
CHEMBL32571 |
C005273
|
57 / 46 / 40 | 35 / 10 | No. 25 | No. 14 |
|
|
C00029821
|
Sitostenone
/ beta-Sitostenone / Stigmast-4-en-3-one / Stigmast-4-ene-3-one |
CHEMBL66926
|
No. 53 | No. 11 |
|
|||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00006442
|
GB-2a
/ (-)-GB-2a |
CHEMBL63792
CHEMBL445452 CHEMBL446790 |
No. 57 | No. 18 |
|
|||
|
C00002968
|
Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene |
CHEMBL187265
|
C069053
|
9 / 10 / 7 | 4 / 0 | No. 71 | No. 15 |
|
|
C00006432
|
Volkensiflavone
|
CHEMBL63919
CHEMBL463023 |
No. 88 |
|
||||
|
C00006435
|
Fukugetin
/ Morelloflavone / (+)-Morelloflavone |
CHEMBL63226
CHEMBL1215433 |
C105620
|
No. 88 |
|
|||
|
C00047134
|
13,14-Didehydroxyisogarcinol
/ (-)-13,14-Didehydroxyisogarcinol |
CHEMBL554161
|
No. 123 |
|
||||
|
C00047239
|
Garcimultiflorone B
/ (-)-Garcimultiflorone B |
CHEMBL556137
|
No. 123 |
|
||||
|
C00047135
|
13-Hydroxygarcimultiflorone B
/ (-)-13-Hydroxygarcimultiflorone B |
CHEMBL555031
|
No. 123 |
|
||||
|
C00035077
|
delta-Tocotrienol
|
CHEMBL121305
|
C082097
|
1 / 0 / 0 | 10 / 0 | No. 328 |
|
|
|
C00006437
|
Fukugeside
|
CHEMBL503951
|
No. 341 |
|
||||
|
C00006444
|
Xanthochymusside
|
No. 341 |
|
|||||
|
C00006440
|
GB1a-7''-O-glucoside
|
CHEMBL451411
|
No. 341 |
|
||||
|
C00006434
|
Spicatiside
|
No. 341 |
|
|||||
|
C00003755
|
Squalene
/ Supraene / Spinacene |
CHEMBL458402
|
D013185
|
1 / 1 / 2 | 1 / 1 | No. 801 | No. 50 |
|
|
C00002498
|
Scoparone
/ 6,7-Dimethoxycoumarin / Aesculetin dimethyl ether |
CHEMBL325864
|
C018145
|
4 / 2 / 2 | 6 / 0 | No. 864 | No. 25 |
|
|
C00047240
|
Garcimultiflorone C
/ (-)-Garcimultiflorone C |
CHEMBL556944
|
No. 1164 |
|
||||
|
C00044456
|
4,6,4'-Trihydroxy-2,3'-dimethoxy-3-prenylbenzophenone
|
No. 1707 |
|
|||||
|
C00044468
|
6,3'-Dihydroxy-2,4-dimethoxybenzophenone
|
No. 1801 |
|
|||||
|
C00044455
|
4,6,3',4'-Tetrahydroxy-2-methoxybenzophenone
|
CHEMBL452764
|
No. 1837 |
|
||||
|
C00003003
|
Maclurin
|
CHEMBL506731
|
No. 1837 |
|
||||
|
C00029431
|
2,3',4,6-Tetrahydroxybenzophenone
/ 2,4,6,3'-Tetrahydroxybenzophenone |
CHEMBL445711
|
No. 1837 |
|
||||
|
C00044778
|
Garcinianone A
|
CHEMBL452501
CHEMBL452502 |
No. 3043 |
|
||||
|
C00044779
|
Garcinianone B
|
CHEMBL452501
CHEMBL452502 |
No. 3043 |
|
||||
|
C00044401
|
(1E,22Z)-1,22-Diferuloyloxydocosane
|
No. 6071 |
|
Human Protein / Gene in interactions
82 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000982 C00003672 | 1 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000982 C00003672 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000982 C00003672 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000982 C00003672 | 1 / 1 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000982 C00003672 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00000982 C00003672 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000982 C00003672 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000982 C00003755 | 1 / 2 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000982 C00003672 | 0 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00000982 C00003672 | 1 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00023774 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00002498 C00002968 | 1 / 1 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000982 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00002968 | 2 / 2 |
| P62158 | Calmodulin | Unclassified protein | C00000982 | 1 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000982 | 1 / 1 |
| P05091 | Aldehyde dehydrogenase, mitochondrial | Oxidoreductase | C00002498 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00000982 | 6 / 4 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00000982 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000982 | 0 / 3 |
| P49327 | Fatty acid synthase | Transferase | C00002968 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00000982 | 0 / 0 |
| P24864 | G1/S-specific cyclin-E1 | Other cytosolic protein | C00000982 | 0 / 2 |
| O75828 | Carbonyl reductase [NADPH] 3 | Enzyme | C00000982 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00000982 | 0 / 0 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00000982 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00000982 | 1 / 1 |
| P16152 | Carbonyl reductase [NADPH] 1 | Enzyme | C00000982 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000982 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00000982 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00000982 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000982 | 0 / 1 |
| P15121 | Aldose reductase | Enzyme | C00000982 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002968 | 0 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000982 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00000982 | 1 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000982 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000982 | 0 / 1 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00000982 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000982 | 5 / 3 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00000982 | 4 / 4 |
| P04745 | Alpha-amylase 1 | Enzyme | C00000982 | 0 / 0 |
| P45452 | Collagenase 3 | M10A | C00002968 | 1 / 1 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00000982 | 2 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00002498 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000982 | 0 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00002968 | 1 / 3 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000982 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00000982 | 2 / 0 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00000982 | 1 / 1 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000982 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00000982 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00000982 | 1 / 0 |
| P39900 | Macrophage metalloelastase | M10A | C00002968 | 0 / 0 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002968 | 4 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00000982 | 1 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00000982 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000982 | 3 / 0 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00000982 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00000982 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000982 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000982 | 5 / 1 |
| O43451 | Maltase-glucoamylase, intestinal | Hydrolase | C00035077 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000982 | 3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00000982 | 0 / 0 |
| Q04760 | Lactoylglutathione lyase | Enzyme | C00000982 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00002968 | 1 / 0 |
| P49888 | Estrogen sulfotransferase | Enzyme | C00000982 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00000982 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00000982 | 2 / 5 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00023774 | 0 / 0 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
| P27338 | Amine oxidase [flavin-containing] B | Oxidoreductase | C00002498 | 0 / 0 |
52 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000982
C00035077
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002968
C00035077
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00000982
C00035077
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00000982
C00003755
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00000982
C00002498
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00000982
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000982
|
| 249 | ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP | alkaline phosphatase, liver/bone/kidney (EC:3.1.3.1) |
C00000982
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00000982
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00000982
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000982
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000982
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000982
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000982
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00000982
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000982
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00000982
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00000982
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00000982
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00000982
|
| 1645 | AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB | aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) |
C00000982
|
| 3757 | KCNH2, ERG1, HERG, HERG1, Kv11.1, LQT2, SQT1 | potassium voltage-gated channel, subfamily H (eag-related), member 2 |
C00000982
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000982
|
| 6566 | SLC16A1, HHF7, MCT, MCT1 | solute carrier family 16 (monocarboxylate transporter), member 1 |
C00000982
|
| 6513 | SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED | solute carrier family 2 (facilitated glucose transporter), member 1 |
C00000982
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00000982
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00000982
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000982
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000982
|
| 10057 | ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
C00000982
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00000982
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00000982
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00000982
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00000982
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00000982
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002498
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00002498
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00002498
|
| 5966 | REL, C-Rel | v-rel avian reticuloendotheliosis viral oncogene homolog |
C00002498
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002498
|
| 10257 | ABCC4, EST170205, MOAT-B, MOATB, MRP4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 |
C00000982
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00002968
|
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00002968
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002968
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00035077
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00035077
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00035077
|
| 4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00035077
|
| 9611 | NCOR1, N-CoR, N-CoR1, TRAC1, hN-CoR | nuclear receptor corepressor 1 |
C00035077
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00035077
|
| 7471 | WNT1, BMND16, INT1, OI15 | wingless-type MMTV integration site family, member 1 |
C00035077
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (70)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #610251 | Alcohol sensitivity, acute |
P05091
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| %606641 | Body mass index; bmi |
P37231
|
| #300615 | Brunner syndrome |
P21397
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #133239 | Esophageal cancer |
P18054
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #601665 | Obesity |
P37231
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #604229 | Peters anomaly |
Q16678
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
| #601367 | Stroke, ischemic |
P00734
P12821 |
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #614916 | Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 |
P62158
|
| #278300 | Xanthinuria, type i |
P47989
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (54)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H01071 | Acute alcohol sensitivity |
P05091
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H00018 | Gastric cancer |
P24864
(related)
|
| H00055 | Laryngeal cancer |
P24864
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P37231
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
11 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00000982
|
| D001932 | Brain Neoplasms |
C00000982
|
| D009202 | Cardiomyopathies |
C00000982
|
| D056486 | Drug-Induced Liver Injury |
C00000982
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00000982
|
| D007674 | Kidney Diseases |
C00000982
|
| D008106 | Liver Cirrhosis, Experimental |
C00000982
|
| D008107 | Liver Diseases |
C00000982
|
| D009369 | Neoplasms |
C00000982
|
| D009374 | Neoplasms, Experimental |
C00000982
|
| D009203 | Myocardial Infarction |
C00003755
|