Species

KNApSAcK Entry

Organism name Clarisia racemosa R.et P.
Genus Clarisia
Family Moraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Clarisia
Linked NCBI taxonomy ID 241873
Linked level genus

Family

Family in NCBI taxonomy Moraceae
ID 3487

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00002968 External link 512 Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene
CHEMBL187265
C069053
9 / 10 / 7 4 / 0 No. 71 No. 15

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P06746 DNA polymerase beta Enzyme C00003672 0 / 0
P39900 Macrophage metalloelastase M10A C00002968 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002968 2 / 2
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002968 1 / 1
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P49327 Fatty acid synthase Transferase C00002968 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P03956 Interstitial collagenase M10A C00002968 0 / 1
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P45452 Collagenase 3 M10A C00002968 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P08253 72 kDa type IV collagenase M10A C00002968 1 / 3
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P12821 Angiotensin-converting enzyme M2 C00002968 4 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003672 0 / 1
P08254 Stromelysin-1 M10A C00002968 1 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002968
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002968
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00002968
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002968

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#300615 Brunner syndrome P21397
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#267430 Renal tubular dysgenesis; rtd P12821
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P00734
P12821
#188050 Thrombophilia due to thrombin defect; thph1 P00734

KEGG DISEASE (19)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00026 Endometrial Cancer P03372 (marker)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)