Species

KNApSAcK Entry

Organism name Hypericum chinense
Genus Hypericum
Family Hypericaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Hypericum
Linked NCBI taxonomy ID 55962
Linked level genus

Family

Family in NCBI taxonomy Hypericaceae
ID 629714

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (30)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00034991 External link 512 1,3-Dihydroxy-2-methoxyxanthone
No. 3 No. 15
C00048290 External link 512 4-Hydroxy-2,3-dimethoxy-xanthone
No. 3 No. 15
C00029358 External link 512 1,3,5-Trihydroxy-6-methoxyxanthone
No. 3 No. 15
C00048249 External link 512 1,3-Dihydroxy-5-methoxy-xanthone
No. 3 No. 15
C00029436 External link 512 2,6-Dihydroxy-3,4-dimethoxyxanthone
No. 3 No. 15
C00029482 External link 512 3,6-Dihydroxy-1,2-dimethoxyxanthone
CHEMBL2029864
No. 3 No. 15
C00029483 External link 512 3,7-Dihydroxy-2,4-dimethoxyxanthone
No. 3 No. 15
C00029500 External link 512 2,4-Dimethoxy-3-hydroxyxanthone
/ 3-Hydroxy-2,4-dimethoxyxanthone
No. 3 No. 15
C00035000 External link 512 2,5-Dihydroxy-1-methoxyxanthone
No. 3 No. 15
C00029522 External link 512 4,7-Dihydroxy-2,3-dimethoxyxanthone
No. 3 No. 15
C00029574 External link 512 6-Hydroxy-2,3,4-trimethoxyxanthone
No. 3 No. 15
C00035017 External link 512 3,5-Dihydroxy-1,2-dimethoxyxanthone
No. 3 No. 15
C00034993 External link 512 1,7-Dihydroxy-6-methoxyxanthone
No. 3 No. 15
C00032586 External link 512 1,3,6-Trihydroxy-5-methoxyxanthone
No. 3 No. 15
C00034990 External link 512 1,3,7-Trihydroxy-5,6-dimethoxyxanthone
No. 3 No. 15
C00029521 External link 512 4,6-Dihydroxy-2,3-dimethoxyxanthone
No. 3 No. 15
C00032369 External link 512 Toxyloxanthone B
CHEMBL482997
No. 24 No. 15
C00002968 External link 512 Norathyriol
/ 1,3,6,7-Tetrahydroxyxanthoene
CHEMBL187265
C069053
9 / 10 / 7 4 / 0 No. 71 No. 15
C00031484 External link 512 1,3,5,6-Tetrahydroxyxanthone
CHEMBL448040
1 / 4 / 2 No. 71 No. 15
C00035014 External link 512 2-Hydroxyxanthone
CHEMBL185960
1 / 1 / 1 No. 76 No. 15
C00035012 External link 512 2-Hydroxy-1-methoxyxanthone
CHEMBL1923834
No. 76 No. 15
C00035003 External link 512 2,7-Dihydroxyxanthone
CHEMBL448874
No. 76 No. 15
C00048275 External link 512 2-Hydroxy-5-methoxy-xanthone
No. 76 No. 15
C00029364 External link 512 Euxanthone
/ 1,7-Dihydroxyxanthone
CHEMBL389166
C404221
1 / 0 / 0 No. 76 No. 15
C00048548 External link 512 Subalatin
/ (+)-Subalatin
No. 338
C00036855 External link 512 Cadensin G
CHEMBL462866
No. 338
C00048278 External link 512 2-O-Demethylkielcorin
/ (+)-2-O-Demethylkielcorin
No. 338
C00048352 External link 512 Chinexanthone A
No. 863 No. 65
C00011509 External link 512 Hyperolactone A
CHEMBL1081690
No. 5496
C00047762 External link 512 Biyouyanagin B
CHEMBL1081151
No. 6086

Human Protein / Gene in interactions

10 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002968 C00035014 1 / 1
P12821 Angiotensin-converting enzyme M2 C00002968 C00031484 4 / 2
P03956 Interstitial collagenase M10A C00002968 0 / 1
P35610 Sterol O-acyltransferase 1 Enzyme C00029364 0 / 0
P49327 Fatty acid synthase Transferase C00002968 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00002968 2 / 2
P45452 Collagenase 3 M10A C00002968 1 / 1
P08253 72 kDa type IV collagenase M10A C00002968 1 / 3
P39900 Macrophage metalloelastase M10A C00002968 0 / 0
P08254 Stromelysin-1 M10A C00002968 1 / 0

4 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
5243 ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) C00002968
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00002968
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00002968
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002968

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (10)

OMIM preferred title UniProt
#300615 Brunner syndrome P21397
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#614519 Hemorrhage, intracerebral, susceptibility to; ich P12821
#603932 Intervertebral disc disease; idd P14780
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#612624 Microvascular complications of diabetes, susceptibility to, 3; mvcd3 P12821
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#267430 Renal tubular dysgenesis; rtd P12821
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P12821

KEGG DISEASE (7)

KEGG name UniProt
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00083 Allograft rejection P12821 (related)
H00575 Renal tubular dysgenesis P12821 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00548 Brunner syndrome P21397 (related)