Leptarrhena pyrolifolia
Species
KNApSAcK Entry
| Organism name | Leptarrhena pyrolifolia |
|---|---|
| Genus | Leptarrhena |
| Family | Saxifragaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Leptarrhena pyrolifolia |
|---|---|
| Linked NCBI taxonomy ID | 23253 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Saxifragaceae |
|---|---|
| ID | 3792 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Metabolite list (16)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005737
|
Myricetin 3-rutinoside
/ Myricetin-3-O-rutinoside |
No. 1 | No. 15 |
|
||||
|
C00005548
|
Narcissin
/ Isorhamnetin 3-O-rutinoside |
CHEMBL84174
CHEMBL258394 CHEMBL1711509 CHEMBL2165403 |
C031062
|
7 / 1 / 2 | No. 1 | No. 15 |
|
|
|
C00005169
|
Nicotiflorin
/ Nicotifloroside / Kaempferol 3-O-rutinoside / Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside / (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside |
CHEMBL431610
CHEMBL79790 CHEMBL255020 CHEMBL501550 CHEMBL498879 CHEMBL1419228 CHEMBL1875691 |
22 / 10 / 12 | No. 1 | No. 15 |
|
||
|
C00005373
|
Hirsutrin
/ Isoquercetin / Isoquercetrin / (-)-Isoquercetrin / Quercetin 3-glucoside / Quercetin 3-O-beta-D-glucoside / Quercetin-3-O-beta-D-glucopyranoside / Quercetin 3-O-beta-D-glucopyranoside / (-)-Quercetin-3-O-beta-D-glucopyranoside |
CHEMBL33027
CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 |
38 / 43 / 34 | No. 2 | No. 15 |
|
||
|
C00005137
|
Trifolin
/ Kaempferol 3-O-beta-D-galactopyranoside |
CHEMBL233930
CHEMBL453290 CHEMBL1572115 |
C066407
|
10 / 6 / 7 | 1 / 1 | No. 2 | No. 15 |
|
|
C00005370
|
Reynoutrin
|
CHEMBL183031
CHEMBL185461 CHEMBL488198 CHEMBL464507 CHEMBL520637 |
No. 2 | No. 15 |
|
|||
|
C00005372
|
Hyperin
/ Hyperoside / Quercetin 3-O-galactoside / Quercetin 3-O-beta-D-galactoside / Quercetin 3-beta-galactopyranoside / Quercetin 3-O-beta-D-galactopyranoside |
CHEMBL33027
CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 |
C021304
|
38 / 43 / 34 | 4 / 0 | No. 2 | No. 15 |
|
|
C00005138
|
Astragalin
/ Kaempferol 3-glucoside / Kaempferol 3-O-beta-D-glucoside / Kaempferol 3-O-beta-D-glucopyranoside |
CHEMBL233930
CHEMBL453290 CHEMBL1572115 |
C001579
|
10 / 6 / 7 | 0 / 1 | No. 2 | No. 15 |
|
|
C00005729
|
Myricetin 3-glucoside
/ Myricetin 3-O-beta-D-glucoside / Myricetin 3-O-beta-D-glucopyranoside |
CHEMBL462244
CHEMBL1221722 |
No. 2 | No. 15 |
|
|||
|
C00005524
|
Isorhamnetin 3-galactoside
|
CHEMBL234316
CHEMBL516621 |
1 / 1 / 0 | No. 2 | No. 15 |
|
||
|
C00005525
|
Isorhamnetin 3-glucoside
/ Isorhamnetin 3-O-glucoside / Isorhamnetin 3-O-beta-D-glucoside / Isorhamnetin 3-O-beta-D-glucopyranoside |
CHEMBL234316
CHEMBL516621 |
1 / 1 / 0 | No. 2 | No. 15 |
|
||
|
C00005134
|
Kaempferol 3-xyloside
|
CHEMBL518420
CHEMBL477730 |
No. 2 | No. 15 |
|
|||
|
C00005727
|
Myricetin 3-xyloside
|
No. 2 | No. 15 |
|
||||
|
C00005728
|
Myricetin 3-galactoside
/ Myricetin 3-O-galactoside |
CHEMBL462244
CHEMBL1221722 |
No. 2 | No. 15 |
|
|||
|
C00005523
|
Isorhamnetin 3-xyloside
|
No. 2 | No. 15 |
|
||||
|
C00000938
|
Ampelopsin
/ Dihydromyricetin / (2R,3R)-3,5,7,3',4',5'-Hexahydroxyflavanone |
CHEMBL2048508
|
C106407
|
6 / 5 / 4 | 1 / 0 | No. 42 | No. 14 |
|
Human Protein / Gene in interactions
56 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P07237 | Protein disulfide-isomerase | Enzyme | C00005137 C00005138 C00005169 C00005372 C00005373 C00005548 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005137 C00005138 C00005169 C00005372 C00005373 C00005548 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005137 C00005138 C00005169 C00005372 C00005373 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005137 C00005138 C00005169 C00005372 C00005373 | 1 / 1 |
| P15121 | Aldose reductase | Enzyme | C00005137 C00005138 C00005372 C00005373 | 0 / 0 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00005372 C00005373 C00005524 C00005525 | 1 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00005137 C00005138 C00005372 C00005373 | 4 / 2 |
| O75496 | Geminin | Unclassified protein | C00005169 C00005372 C00005373 C00005548 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00005169 C00005372 C00005373 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005169 C00005372 C00005373 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005169 C00005372 C00005373 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00005137 C00005138 C00005548 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00005169 C00005372 C00005373 | 1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00005169 C00005372 C00005373 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00005137 C00005138 C00005169 | 1 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005169 C00005372 C00005373 | 1 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00005169 C00005372 C00005373 | 1 / 4 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00005169 C00005372 C00005373 | 0 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005169 C00005372 C00005373 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005169 C00005372 C00005373 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005137 C00005138 C00005169 | 0 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00005372 C00005373 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00005372 C00005373 | 1 / 1 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00005372 C00005373 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00005372 C00005373 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00005372 C00005373 | 0 / 0 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005372 C00005373 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005372 C00005373 | 3 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00005372 C00005373 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00005372 C00005373 | 11 / 10 |
| P06280 | Alpha-galactosidase A | Enzyme | C00005372 C00005373 | 1 / 1 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00005137 C00005138 | 0 / 3 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00005372 C00005373 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005372 C00005373 | 0 / 1 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005372 C00005373 | 1 / 1 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00005372 C00005373 | 2 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00005372 C00005373 | 6 / 4 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00005372 C00005373 | 0 / 3 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00005372 C00005373 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00005372 C00005373 | 4 / 3 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00005372 C00005373 | 4 / 1 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00005372 C00005373 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005169 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00005548 | 0 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00005548 | 1 / 1 |
| P08254 | Stromelysin-1 | M10A | C00000938 | 1 / 0 |
| P08253 | 72 kDa type IV collagenase | M10A | C00000938 | 1 / 3 |
| P45452 | Collagenase 3 | M10A | C00000938 | 1 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00005169 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00005169 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00000938 | 0 / 1 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00005548 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00005169 | 2 / 3 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00000938 | 2 / 2 |
| P39900 | Macrophage metalloelastase | M10A | C00000938 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00005169 | 2 / 1 |
6 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00005372
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00005372
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00005372
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00005372
|
| 5320 | PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 | phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4) |
C00005137
|
| 8877 | SPHK1, SPHK | sphingosine kinase 1 (EC:2.7.1.91) |
C00000938
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (54)
| OMIM | preferred title | UniProt |
|---|---|---|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (47)
| KEGG | name | UniProt |
|---|---|---|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00028 | Choriocarcinoma |
P03956
(related)
P08253 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00025 | Penile cancer |
P08253
(related)
P14780 (related) P35354 (related) |
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00192 | Xanthinuria |
P47989
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|