PCIDB

Xylopia aromatica

Species

KNApSAcK Entry

Organism name Xylopia aromatica
Genus Xylopia
Family Annonaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Xylopia
Linked NCBI taxonomy ID 225838
Linked level genus

Family

Family in NCBI taxonomy Annonaceae
ID 22140

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Magnoliophyta
ID 3398

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00005373 External link 512 Hirsutrin
/ Isoquercetin
/ Isoquercetrin
/ (-)-Isoquercetrin
/ Quercetin 3-glucoside
/ Quercetin 3-O-beta-D-glucoside
/ Quercetin-3-O-beta-D-glucopyranoside
/ Quercetin 3-O-beta-D-glucopyranoside
/ (-)-Quercetin-3-O-beta-D-glucopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
38 / 43 / 34 No. 2 No. 15
C00044372 External link 512 Venezenin
CHEMBL453965
No. 6 No. 70
C00044389 External link 512 Xylopien
CHEMBL508848
No. 6 No. 70
C00044093 External link 512 Aromicin
No. 6 No. 70
C00044094 External link 512 Aromin
/ (+)-Aromin
No. 6 No. 70
C00044388 External link 512 Xylopiacin
CHEMBL450461
No. 6 No. 70
C00044387 External link 512 Xylomaticin
CHEMBL322993
CHEMBL507669
No. 6 No. 70
C00044386 External link 512 Xylomatenin
CHEMBL448315
No. 6 No. 70
C00044373 External link 512 Venezinone
No. 6 No. 70
C00023770 External link 512 Sitosterol
/ Stigmasta-5,22-dien-3beta-ol
/ (24R)24-Ethylcholesta-5,22-dien-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11

Human Protein / Gene in interactions

61 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00005373 C00023770 C00023774 0 / 0
P14679 Tyrosinase Oxidoreductase C00005138 C00005373 C00023770 4 / 2
Q9UNA4 DNA polymerase iota Enzyme C00005138 C00005373 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005138 C00005373 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005138 C00005373 1 / 1
P15121 Aldose reductase Enzyme C00005138 C00005373 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005138 C00005373 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00005373 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00023770 1 / 0
P04062 Glucosylceramidase Enzyme C00005373 6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase C00005373 1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 0 / 0
P02545 Prelamin-A/C Unclassified protein C00005373 11 / 10
P08047 Transcription factor Sp1 Unclassified protein C00023770 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00023770 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005373 1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005373 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
P08183 Multidrug resistance protein 1 drug C00023770 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00023770 0 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00023770 2 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005373 1 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00005373 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005373 1 / 1
P39748 Flap endonuclease 1 Enzyme C00005373 0 / 0
O75496 Geminin Unclassified protein C00005373 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00005373 0 / 0
Q99700 Ataxin-2 Unclassified protein C00005138 1 / 1
P49841 Glycogen synthase kinase-3 beta Gsk C00023770 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005373 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005373 0 / 3
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005373 3 / 1
P00734 Prothrombin S1A C00023770 4 / 2
Q16637 Survival motor neuron protein Unclassified protein C00005373 4 / 1
P06280 Alpha-galactosidase A Enzyme C00005373 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00005373 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005373 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00023770 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005373 2 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005138 0 / 0
P03372 Estrogen receptor NR3A1 C00023770 1 / 1
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00005373 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00023770 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00023770 0 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00005373 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00023770 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005373 4 / 3
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005373 1 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005373 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00023770 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00005373 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005373 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005373 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00023770 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00005373 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005373 1 / 4
P11388 DNA topoisomerase 2-alpha Isomerase C00023774 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005373 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (59)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (46)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003876 Dermatitis, Atopic C00005138