Calendula officinalis

• Index
• Plant Species
• Metabolite list (27)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Calendula officinalis
Genus	Calendula
Family	Asteraceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Calendula officinalis
Linked NCBI taxonomy ID	41496
Linked level	species

Family

Family in NCBI taxonomy	Asteraceae
ID	4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (27)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005550	Isorhamnetin 3-rhamnosyl-(1->2)-rhamnoside					No. 1	No. 15
C00005548	Narcissin / Isorhamnetin 3-O-rutinoside	CHEMBL84174 CHEMBL258394 CHEMBL1711509 CHEMBL2165403	C031062	7 / 1 / 2		No. 1	No. 15
C00005547	Isorhamnetin 3-neohesperidoside / Isorhamnetin 3-O-neohesperidoside	CHEMBL442566		1 / 1 / 1		No. 1	No. 15
C00005413	Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989	D012431	25 / 18 / 16	29 / 8	No. 1	No. 15
C00005412	Quercetin 3-neohesperidoside / Quercetin 3-O-neohesperidoside	CHEMBL499824				No. 1	No. 15
C00005373	Hirsutrin / Isoquercetin / Isoquercetrin / (-)-Isoquercetrin / Quercetin 3-glucoside / Quercetin 3-O-beta-D-glucoside / Quercetin-3-O-beta-D-glucopyranoside / Quercetin 3-O-beta-D-glucopyranoside / (-)-Quercetin-3-O-beta-D-glucopyranoside	CHEMBL33027 CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336		38 / 43 / 34		No. 2	No. 15
C00005525	Isorhamnetin 3-glucoside / Isorhamnetin 3-O-glucoside / Isorhamnetin 3-O-beta-D-glucoside / Isorhamnetin 3-O-beta-D-glucopyranoside	CHEMBL234316 CHEMBL516621		1 / 1 / 0		No. 2	No. 15
C00032795	Calendasaponin A / (+)-Calendasaponin A					No. 4	No. 51
C00041407	Calendulaglycoside A 6'-O-methyl ester / (+)-Calendulaglycoside A 6'-O-methyl ester	CHEMBL505078				No. 4	No. 51
C00032799	Calenduloside D / (+)-Calenduloside D					No. 4	No. 51
C00032798	Calendasaponin D / (+)-Calendasaponin D					No. 4	No. 51
C00032797	Calendasaponin C					No. 4	No. 51
C00041406	Calendulaglycoside A	CHEMBL508826 CHEMBL505495 CHEMBL1834952		3 / 5 / 3		No. 4	No. 51
C00005573	Typhaneoside	CHEMBL450526	C051428			No. 5	No. 15
C00005456	Manghaslin / Quercetin 3-2G-rhamnosylrutinoside	CHEMBL444468				No. 5	No. 15
C00041408	Calendulaglycoside B	CHEMBL500221				No. 9	No. 51
C00041409	Calendulaglycoside C	CHEMBL504681 CHEMBL1288832				No. 9	No. 51
C00032796	Calendasaponin B / (+)-Calendasaponin B					No. 9	No. 51
C00003499	Arvensoside A					No. 9	No. 51
C00041410	Taibaienoside IV / Calenduloside F 6'-O-n-butyl ester / (+)-Calenduloside F 6'-O-n-butyl ester	CHEMBL502145				No. 9	No. 51
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15	No. 13	No. 51
C00000911	Lycopene / all-trans-Lycopene	CHEMBL501174 CHEMBL1984187	C015329	6 / 13 / 13	84 / 13	No. 97	No. 59
C00033262	Officinoside B / (+)-Officinoside B					No. 316
C00033261	Officinoside A					No. 316
C00033264	Officinoside D / (-)-Officinoside D					No. 1553
C00033263	Officinoside C / (-)-Officinoside C					No. 1553
C00011408	Icariside C3					No. 1643

Human Protein / Gene in interactions

76 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	C00000911 C00005373 C00005548 C00019064	0 / 0
P03372	Estrogen receptor	NR3A1	C00005413 C00005547 C00005548	1 / 1
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00005373 C00005413 C00019064	0 / 3
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000911 C00005373 C00005413	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00005373 C00005548 C00019064	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000911 C00005373 C00005413	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00005373 C00005413 C00019064	0 / 0
P06746	DNA polymerase beta	Enzyme	C00005373 C00005413 C00019064	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00005548 C00019064	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00005373 C00005413	1 / 1
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00005373 C00005525	1 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00005373 C00005413	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00005413 C00005548	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00005373 C00019064	1 / 4
P10636	Microtubule-associated protein tau	Unclassified protein	C00005373 C00005413	4 / 3
P02545	Prelamin-A/C	Unclassified protein	C00000911 C00005373	11 / 10
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00005373 C00005413	1 / 1
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00005373 C00005413	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00005373 C00005413	2 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00005373 C00005413	0 / 0
P07237	Protein disulfide-isomerase	Enzyme	C00005373 C00005548	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00005373 C00005413	1 / 0
P14679	Tyrosinase	Oxidoreductase	C00005373 C00005413	4 / 2
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000911 C00005413	0 / 0
P15121	Aldose reductase	Enzyme	C00005373 C00019064	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00005373 C00019064	0 / 1
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064	1 / 1
P39748	Flap endonuclease 1	Enzyme	C00005373	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00019064	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00005373	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00005373	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00019064	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00019064	0 / 0
P27487	Dipeptidyl peptidase 4	S9B	C00005413	0 / 1
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00005548	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00005373	1 / 1
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00005373	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00005373	3 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00019064	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000911	2 / 3
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00019064	2 / 2
P11388	DNA topoisomerase 2-alpha	Isomerase	C00005413	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00041406	5 / 3
P06276	Cholinesterase	Hydrolase	C00005413	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00005373	1 / 1
Q96RI1	Bile acid receptor	NR1H4	C00019064	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00019064	0 / 0
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P10696	Alkaline phosphatase, placental-like	Enzyme	C00005373	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00005413	3 / 3
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00019064	0 / 0
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00019064	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00005413	1 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00005373	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00005373	1 / 1
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00019064	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00041406	0 / 0
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00019064	4 / 2
P04062	Glucosylceramidase	Enzyme	C00005373	6 / 4
P33527	Multidrug resistance-associated protein 1	drugs	C00005413	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00041406	0 / 0
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00019064	0 / 1
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00019064	0 / 0
P34949	Mannose-6-phosphate isomerase	Enzyme	C00005373	1 / 1
P48147	Prolyl endopeptidase	S9A	C00005413	0 / 0
P04054	Phospholipase A2	Enzyme	C00019064	0 / 0
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00019064	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00005373	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00005373	4 / 1
Q9NPH5	NADPH oxidase 4	Enzyme	C00005373	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00019064	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00005373	0 / 0

113 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00000911 C00005413 C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00000911 C00005413 C00019064
847	CAT	catalase (EC:1.11.1.6)	C00000911 C00005413 C00019064
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000911 C00005413 C00019064
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000911 C00019064
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00005413 C00019064
7039	TGFA, TFGA	transforming growth factor, alpha	C00000911 C00005413
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00000911 C00019064
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00000911 C00019064
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000911 C00005413
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00000911 C00019064
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00005413 C00019064
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000911 C00005413
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00000911 C00005413
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000911 C00019064
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00000911 C00019064
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00000911 C00019064
2956	MSH6, GTBP, GTMBP, HNPCC5, HSAP, p160	mutS homolog 6	C00000911
1113	CHGA, CGA	chromogranin A (parathyroid secretory protein 1)	C00000911
1114	CHGB, SCG1	chromogranin B (secretogranin 1)	C00000911
23418	CRB1, LCA8, RP12	crumbs homolog 1 (Drosophila)	C00000911
1025	CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK	cyclin-dependent kinase 9 (EC:2.7.11.23 2.7.11.22)	C00000911
1643	DDB2, DDBB, UV-DDB2	damage-specific DNA binding protein 2, 48kDa	C00000911
1981	EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18	eukaryotic translation initiation factor 4 gamma, 1	C00000911
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000911
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000911
2176	FANCC, FA3, FAC, FACC	Fanconi anemia, complementation group C	C00000911
2188	FANCF, FAF	Fanconi anemia, complementation group F	C00000911
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00000911
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00000911
2701	GJA4, CX37	gap junction protein, alpha 4, 37kDa	C00000911
2702	GJA5, ATFB11, CX40	gap junction protein, alpha 5, 40kDa	C00000911
2879	GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx	glutathione peroxidase 4 (EC:1.11.1.12)	C00000911
1022	CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15	cyclin-dependent kinase 7 (EC:2.7.11.23 2.7.11.22)	C00000911
1020	CDK5, PSSALRE	cyclin-dependent kinase 5 (EC:2.7.11.22)	C00000911
3479	IGF1, IGF-I, IGF1A, IGFI	insulin-like growth factor 1 (somatomedin C)	C00000911
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00000911
3485	IGFBP2, IBP2, IGF-BP53	insulin-like growth factor binding protein 2, 36kDa	C00000911
3713	IVL	involucrin	C00000911
3716	JAK1, JAK1A, JAK1B, JTK3	Janus kinase 1 (EC:2.7.10.2)	C00000911
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00000911
3796	KIF2A, CDCBM3, HK2, KIF2	kinesin heavy chain member 2A	C00000911
3838	KPNA2, IPOA1, QIP2, RCH1, SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	C00000911
3949	LDLR, FH, FHC, LDLCQ2	low density lipoprotein receptor	C00000911
3988	LIPA, CESD, LAL	lipase A, lysosomal acid, cholesterol esterase (EC:3.1.1.13)	C00000911
5604	MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1	mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)	C00000911
5605	MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2	mitogen-activated protein kinase kinase 2 (EC:2.7.12.2)	C00000911
6416	MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1	mitogen-activated protein kinase kinase 4 (EC:2.7.12.2)	C00000911
5608	MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3	mitogen-activated protein kinase kinase 6 (EC:2.7.12.2)	C00000911
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00000911
898	CCNE1, CCNE	cyclin E1	C00000911
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000911
4247	MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC:2.4.1.143)	C00000911
100507436	MICA, MIC-A, PERB11.1	MHC class I polypeptide-related sequence A	C00000911
4292	MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1	mutL homolog 1	C00000911
4436	MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2	mutS homolog 2	C00000911
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00000911
4842	NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS	nitric oxide synthase 1 (neuronal) (EC:1.14.13.39)	C00000911
8021	NUP214, CAIN, CAN, D9S46E, N214, p250	nucleoporin 214kDa	C00000911
5320	PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2	phospholipase A2, group IIA (platelets, synovial fluid) (EC:3.1.1.4)	C00000911
5591	PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350	protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1)	C00000911
10111	RAD50, NBSLD, RAD502, hRad50	RAD50 homolog (S. cerevisiae)	C00000911
8045	RASSF7, C11orf13, HRAS1, HRC1	Ras association (RalGDS/AF-6) domain family (N-terminal) member 7	C00000911
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00000911
5962	RDX, DFNB24	radixin	C00000911
6195	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1	ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1)	C00000911
6197	RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2	ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC:2.7.11.1)	C00000911
6241	RRM2, R2, RR2, RR2M	ribonucleotide reductase M2 (EC:1.17.4.1)	C00000911
673	BRAF, B-RAF1, BRAF1, NS7, RAFB1	v-raf murine sarcoma viral oncogene homolog B (EC:2.7.11.1)	C00000911
6414	SEPP1, SELP, SeP	selenoprotein P, plasma, 1	C00000911
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00000911
8243	SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB	structural maintenance of chromosomes 1A	C00000911
6774	STAT3, APRF, HIES	signal transducer and activator of transcription 3 (acute-phase response factor)	C00000911
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00000911
7980	TFPI2, PP5, REF1, TFPI-2	tissue factor pathway inhibitor 2	C00000911
8314	BAP1, HUCEP-13, UCHL2	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (EC:3.4.19.12)	C00000911
7097	TLR2, CD282, TIL4	toll-like receptor 2	C00000911
7099	TLR4, ARMD10, CD284, TLR-4, TOLL	toll-like receptor 4	C00000911
571	BACH1, BACH-1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	C00000911
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000911
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00000911
7415	VCP, ALS14, IBMPFD, IBMPFD1, TERA, p97	valosin containing protein (EC:3.6.4.6)	C00000911
7485	WRB, CHD5	tryptophan rich basic protein	C00000911
7697	ZNF138, pHZ-32	zinc finger protein 138	C00000911
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000911
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00019064
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
118	ADD1, ADDA	adducin 1 (alpha)	C00000911
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00019064
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00019064
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00019064
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00019064
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00005413
581	BAX, BCL2L4	BCL2-associated X protein	C00005413
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00005413
873	CBR1, CBR, SDR21C1, hCBR1	carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)	C00005413
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00005413
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00005413
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00005413
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00005413
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00005413
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00005413
3458	IFNG, IFG, IFI	interferon, gamma	C00005413
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00005413
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00005413
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00005413
3667	IRS1, HIRS-1	insulin receptor substrate 1	C00005413
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00005413
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00005413
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00005413
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00005413

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