KNApSAcK Entry

Organism name Calendula officinalis
Genus Calendula
Family Asteraceae
Kingdom Plantae

NCBI taxonomy


Linked NCBI taxonomy name Calendula officinalis
Linked NCBI taxonomy ID 41496
Linked level species


Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (27)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00005550 External link 512 Isorhamnetin 3-rhamnosyl-(1->2)-rhamnoside
No. 1 No. 15
C00005548 External link 512 Narcissin
/ Isorhamnetin 3-O-rutinoside
7 / 1 / 2 No. 1 No. 15
C00005547 External link 512 Isorhamnetin 3-neohesperidoside
/ Isorhamnetin 3-O-neohesperidoside
1 / 1 / 1 No. 1 No. 15
C00005413 External link 512 Rutin
/ Birutan
/ 3-Rutinosylquercetin
/ Quercetin 3-O-rutinoside
/ (+)-Quercetin 3-O-rutinoside
/ Quercetin 3-O-beta-rutinoside
/ (+)-Quercetin 3-O-beta-rutinoside
/ 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside
/ Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
25 / 18 / 16 29 / 8 No. 1 No. 15
C00005412 External link 512 Quercetin 3-neohesperidoside
/ Quercetin 3-O-neohesperidoside
No. 1 No. 15
C00005373 External link 512 Hirsutrin
/ Isoquercetin
/ Isoquercetrin
/ (-)-Isoquercetrin
/ Quercetin 3-glucoside
/ Quercetin 3-O-beta-D-glucoside
/ Quercetin-3-O-beta-D-glucopyranoside
/ Quercetin 3-O-beta-D-glucopyranoside
/ (-)-Quercetin-3-O-beta-D-glucopyranoside
38 / 43 / 34 No. 2 No. 15
C00005525 External link 512 Isorhamnetin 3-glucoside
/ Isorhamnetin 3-O-glucoside
/ Isorhamnetin 3-O-beta-D-glucoside
/ Isorhamnetin 3-O-beta-D-glucopyranoside
1 / 1 / 0 No. 2 No. 15
C00032795 External link 512 Calendasaponin A
/ (+)-Calendasaponin A
No. 4 No. 51
C00041407 External link 512 Calendulaglycoside A 6'-O-methyl ester
/ (+)-Calendulaglycoside A 6'-O-methyl ester
No. 4 No. 51
C00032799 External link 512 Calenduloside D
/ (+)-Calenduloside D
No. 4 No. 51
C00032798 External link 512 Calendasaponin D
/ (+)-Calendasaponin D
No. 4 No. 51
C00032797 External link 512 Calendasaponin C
No. 4 No. 51
C00041406 External link 512 Calendulaglycoside A
3 / 5 / 3 No. 4 No. 51
C00005573 External link 512 Typhaneoside
No. 5 No. 15
C00005456 External link 512 Manghaslin
/ Quercetin 3-2G-rhamnosylrutinoside
No. 5 No. 15
C00041408 External link 512 Calendulaglycoside B
No. 9 No. 51
C00041409 External link 512 Calendulaglycoside C
No. 9 No. 51
C00032796 External link 512 Calendasaponin B
/ (+)-Calendasaponin B
No. 9 No. 51
C00003499 External link 512 Arvensoside A
No. 9 No. 51
C00041410 External link 512 Taibaienoside IV
/ Calenduloside F 6'-O-n-butyl ester
/ (+)-Calenduloside F 6'-O-n-butyl ester
No. 9 No. 51
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
30 / 8 / 12 21 / 15 No. 13 No. 51
C00000911 External link 512 Lycopene
/ all-trans-Lycopene
6 / 13 / 13 84 / 13 No. 97 No. 59
C00033262 External link 512 Officinoside B
/ (+)-Officinoside B
No. 316
C00033261 External link 512 Officinoside A
No. 316
C00033264 External link 512 Officinoside D
/ (-)-Officinoside D
No. 1553
C00033263 External link 512 Officinoside C
/ (-)-Officinoside C
No. 1553
C00011408 External link 512 Icariside C3
No. 1643

Human Protein / Gene in interactions

76 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
O75496 Geminin Unclassified protein C00000911 C00005373 C00005548 C00019064 0 / 0
P03372 Estrogen receptor NR3A1 C00005413 C00005547 C00005548 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005373 C00005413 C00019064 0 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000911 C00005373 C00005413 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00005373 C00005548 C00019064 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000911 C00005373 C00005413 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005373 C00005413 C00019064 0 / 0
P06746 DNA polymerase beta Enzyme C00005373 C00005413 C00019064 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005548 C00019064 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005373 C00005413 1 / 1
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005373 C00005525 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005373 C00005413 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00005413 C00005548 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00005373 C00019064 1 / 4
P10636 Microtubule-associated protein tau Unclassified protein C00005373 C00005413 4 / 3
P02545 Prelamin-A/C Unclassified protein C00000911 C00005373 11 / 10
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005373 C00005413 1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005373 C00005413 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005373 C00005413 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00005373 C00005413 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005373 C00005548 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005373 C00005413 1 / 0
P14679 Tyrosinase Oxidoreductase C00005373 C00005413 4 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000911 C00005413 0 / 0
P15121 Aldose reductase Enzyme C00005373 C00019064 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00005373 C00019064 0 / 1
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
P39748 Flap endonuclease 1 Enzyme C00005373 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00019064 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00005373 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00005413 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00005373 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00019064 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019064 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005413 0 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00005548 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005373 1 / 1
P09923 Intestinal-type alkaline phosphatase Enzyme C00005373 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005373 3 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00019064 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000911 2 / 3
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00019064 2 / 2
P11388 DNA topoisomerase 2-alpha Isomerase C00005413 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00041406 5 / 3
P06276 Cholinesterase Hydrolase C00005413 0 / 0
P06280 Alpha-galactosidase A Enzyme C00005373 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00019064 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00019064 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00019064 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00019064 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005373 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00005413 3 / 3
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00019064 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00019064 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00019064 0 / 0
P22303 Acetylcholinesterase Hydrolase C00005413 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00005373 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005373 1 / 1
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00019064 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00041406 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00019064 4 / 2
P04062 Glucosylceramidase Enzyme C00005373 6 / 4
P33527 Multidrug resistance-associated protein 1 drugs C00005413 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00041406 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00019064 0 / 1
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00019064 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005373 1 / 1
P48147 Prolyl endopeptidase S9A C00005413 0 / 0
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00019064 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00019064 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00005373 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00005373 4 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00005373 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019064 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005373 0 / 0

113 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
177 AGER, RAGE advanced glycosylation end product-specific receptor C00000911 C00005413 C00019064
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC: C00000911 C00005413 C00019064
847 CAT catalase (EC: C00000911 C00005413 C00019064
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000911 C00005413 C00019064
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC: C00000911 C00019064
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC: C00005413 C00019064
7039 TGFA, TFGA transforming growth factor, alpha C00000911 C00005413
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00000911 C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00000911 C00019064
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000911 C00005413
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000911 C00019064
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC: C00005413 C00019064
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00000911 C00005413
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC: C00000911 C00005413
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000911 C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00000911 C00019064
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC: C00000911 C00019064
2956 MSH6, GTBP, GTMBP, HNPCC5, HSAP, p160 mutS homolog 6 C00000911
1113 CHGA, CGA chromogranin A (parathyroid secretory protein 1) C00000911
1114 CHGB, SCG1 chromogranin B (secretogranin 1) C00000911
23418 CRB1, LCA8, RP12 crumbs homolog 1 (Drosophila) C00000911
1025 CDK9, C-2k, CDC2L4, CTK1, PITALRE, TAK cyclin-dependent kinase 9 (EC: C00000911
1643 DDB2, DDBB, UV-DDB2 damage-specific DNA binding protein 2, 48kDa C00000911
1981 EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18 eukaryotic translation initiation factor 4 gamma, 1 C00000911
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000911
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000911
2176 FANCC, FA3, FAC, FACC Fanconi anemia, complementation group C C00000911
2188 FANCF, FAF Fanconi anemia, complementation group F C00000911
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00000911
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00000911
2701 GJA4, CX37 gap junction protein, alpha 4, 37kDa C00000911
2702 GJA5, ATFB11, CX40 gap junction protein, alpha 5, 40kDa C00000911
2879 GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, snGPx, snPHGPx glutathione peroxidase 4 (EC: C00000911
1022 CDK7, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15 cyclin-dependent kinase 7 (EC: C00000911
1020 CDK5, PSSALRE cyclin-dependent kinase 5 (EC: C00000911
3479 IGF1, IGF-I, IGF1A, IGFI insulin-like growth factor 1 (somatomedin C) C00000911
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC: C00000911
3485 IGFBP2, IBP2, IGF-BP53 insulin-like growth factor binding protein 2, 36kDa C00000911
3713 IVL involucrin C00000911
3716 JAK1, JAK1A, JAK1B, JTK3 Janus kinase 1 (EC: C00000911
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC: C00000911
3796 KIF2A, CDCBM3, HK2, KIF2 kinesin heavy chain member 2A C00000911
3838 KPNA2, IPOA1, QIP2, RCH1, SRP1alpha karyopherin alpha 2 (RAG cohort 1, importin alpha 1) C00000911
3949 LDLR, FH, FHC, LDLCQ2 low density lipoprotein receptor C00000911
3988 LIPA, CESD, LAL lipase A, lysosomal acid, cholesterol esterase (EC: C00000911
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC: C00000911
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC: C00000911
6416 MAP2K4, JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1 mitogen-activated protein kinase kinase 4 (EC: C00000911
5608 MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3 mitogen-activated protein kinase kinase 6 (EC: C00000911
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC: C00000911
898 CCNE1, CCNE cyclin E1 C00000911
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC: C00000911
4247 MGAT2, CDG2A, CDGS2, GLCNACTII, GNT-II, GNT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (EC: C00000911
100507436 MICA, MIC-A, PERB11.1 MHC class I polypeptide-related sequence A C00000911
4292 MLH1, COCA2, FCC2, HNPCC, HNPCC2, hMLH1 mutL homolog 1 C00000911
4436 MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2 mutS homolog 2 C00000911
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000911
4842 NOS1, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS nitric oxide synthase 1 (neuronal) (EC: C00000911
8021 NUP214, CAIN, CAN, D9S46E, N214, p250 nucleoporin 214kDa C00000911
5320 PLA2G2A, MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 phospholipase A2, group IIA (platelets, synovial fluid) (EC: C00000911
5591 PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 protein kinase, DNA-activated, catalytic polypeptide (EC: C00000911
10111 RAD50, NBSLD, RAD502, hRad50 RAD50 homolog (S. cerevisiae) C00000911
8045 RASSF7, C11orf13, HRAS1, HRC1 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 C00000911
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000911
5962 RDX, DFNB24 radixin C00000911
6195 RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC: C00000911
6197 RPS6KA3, CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2 ribosomal protein S6 kinase, 90kDa, polypeptide 3 (EC: C00000911
6241 RRM2, R2, RR2, RR2M ribonucleotide reductase M2 (EC: C00000911
673 BRAF, B-RAF1, BRAF1, NS7, RAFB1 v-raf murine sarcoma viral oncogene homolog B (EC: C00000911
6414 SEPP1, SELP, SeP selenoprotein P, plasma, 1 C00000911
4088 SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3 SMAD family member 3 C00000911
8243 SMC1A, CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB structural maintenance of chromosomes 1A C00000911
6774 STAT3, APRF, HIES signal transducer and activator of transcription 3 (acute-phase response factor) C00000911
7031 TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 trefoil factor 1 C00000911
7980 TFPI2, PP5, REF1, TFPI-2 tissue factor pathway inhibitor 2 C00000911
8314 BAP1, HUCEP-13, UCHL2 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (EC: C00000911
7097 TLR2, CD282, TIL4 toll-like receptor 2 C00000911
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00000911
571 BACH1, BACH-1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 C00000911
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000911
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00000911
7415 VCP, ALS14, IBMPFD, IBMPFD1, TERA, p97 valosin containing protein (EC: C00000911
7485 WRB, CHD5 tryptophan rich basic protein C00000911
7697 ZNF138, pHZ-32 zinc finger protein 138 C00000911
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC: C00000911
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC: C00019064
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC: C00019064
118 ADD1, ADDA adducin 1 (alpha) C00000911
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC: C00019064
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC: C00019064
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC: C00019064
7150 TOP1, TOPI topoisomerase (DNA) I (EC: C00019064
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC: C00019064
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00005413
581 BAX, BCL2L4 BCL2-associated X protein C00005413
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00005413
873 CBR1, CBR, SDR21C1, hCBR1 carbonyl reductase 1 (EC: C00005413
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00005413
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00005413
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC: C00005413
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC: C00005413
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC: C00005413
2936 GSR glutathione reductase (EC: C00005413
3458 IFNG, IFG, IFI interferon, gamma C00005413
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00005413
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00005413
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00005413
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00005413
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00005413
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC: C00005413
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00005413
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (62)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#611162 Malaria, susceptibility to P35228
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#163950 Noonan syndrome 1; ns1 Q06124
#601665 Obesity P37231
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303


KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00408 Type I diabetes mellitus P17706 (related)
H00032 Thyroid cancer P27487 (marker)
P37231 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00017 Esophageal cancer P35228 (related)
P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

31 disease in interactions with metabolites

D007674 Kidney Diseases C00000911
D056486 Drug-Induced Liver Injury C00000911
D009369 Neoplasms C00000911
D007249 Inflammation C00000911
D018149 Glucose Intolerance C00019064
D006965 Hyperplasia C00000911
D006943 Hyperglycemia C00000911
D020258 Neurotoxicity Syndromes C00000911
D011471 Prostatic Neoplasms C00000911
D012878 Skin Neoplasms C00000911
D013733 Testicular Diseases C00000911
D014178 Translocation, Genetic C00000911
D015431 Weight Loss C00000911
D002252 Carbon Tetrachloride Poisoning C00019064
D050171 Dyslipidemias C00019064
D007248 Infertility, Male C00000911
D006949 Hyperlipidemias C00019064
D008103 Liver Cirrhosis C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D008107 Liver Diseases C00019064
D017202 Myocardial Ischemia C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064
D001424 Bacterial Infections C00005413
D003092 Colitis C00005413
D004409 Dyskinesia, Drug-Induced C00005413
D015212 Inflammatory Bowel Diseases C00005413
D028361 Mitochondrial Diseases C00005413
D010243 Paralysis C00005413
D013276 Stomach Ulcer C00005413