Salvia miltiorrhiza
Species
KNApSAcK Entry
| Organism name | Salvia miltiorrhiza |
|---|---|
| Genus | Salvia |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Salvia miltiorrhiza |
|---|---|
| Linked NCBI taxonomy ID | 226208 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (38)
| Species | Activity |
|---|---|
| Salvia miltiorrhiza Bunge | Alterative |
| Salvia miltiorrhiza Bunge | Antiaggregant |
| Salvia miltiorrhiza Bunge | Antiaging |
| Salvia miltiorrhiza Bunge | Antiallergic |
| Salvia miltiorrhiza Bunge | Antiandrogenic |
| Salvia miltiorrhiza Bunge | Antianginal |
| Salvia miltiorrhiza Bunge | Antiarthritic |
| Salvia miltiorrhiza Bunge | Antibacterial |
| Salvia miltiorrhiza Bunge | Anticarcinomic |
| Salvia miltiorrhiza Bunge | Antihypoxic |
| Salvia miltiorrhiza Bunge | Antiinflammatory |
| Salvia miltiorrhiza Bunge | Antimutagenic |
| Salvia miltiorrhiza Bunge | Antioxidant |
| Salvia miltiorrhiza Bunge | Antipyretic |
| Salvia miltiorrhiza Bunge | Antiseptic |
| Salvia miltiorrhiza Bunge | Antispasmodic |
| Salvia miltiorrhiza Bunge | Antithrombic |
| Salvia miltiorrhiza Bunge | Astringent |
| Salvia miltiorrhiza Bunge | Bitter |
| Salvia miltiorrhiza Bunge | Calcium Antagonist |
| Salvia miltiorrhiza Bunge | Cardioprotective |
| Salvia miltiorrhiza Bunge | Cardiotonic |
| Salvia miltiorrhiza Bunge | Circulotonic |
| Salvia miltiorrhiza Bunge | Fibrinolytic |
| Salvia miltiorrhiza Bunge | Fungicide |
| Salvia miltiorrhiza Bunge | Hepatoprotective |
| Salvia miltiorrhiza Bunge | Hepatoregenerative |
| Salvia miltiorrhiza Bunge | Hyocholesterolemic |
| Salvia miltiorrhiza Bunge | Hypotensive |
| Salvia miltiorrhiza Bunge | Lipolytic |
| Salvia miltiorrhiza Bunge | Negative Inotropic |
| Salvia miltiorrhiza Bunge | Nephroprotective |
| Salvia miltiorrhiza Bunge | Sedative |
| Salvia miltiorrhiza Bunge | Swelling |
| Salvia miltiorrhiza Bunge | Tonic |
| Salvia miltiorrhiza Bunge | Tranquilizer |
| Salvia miltiorrhiza Bunge | Vasodilator |
| Salvia miltiorrhiza Bunge | Vulnerary |
Metabolite list (23)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00036584
|
5,3'-Dihydroxy-7-4'-dimethoxyflavanone
|
No. 25 | No. 14 |
|
||||
|
C00002772
|
Salvianolic acid A
|
CHEMBL457077
|
C066201
|
5 / 5 / 7 | 0 / 3 | No. 494 |
|
|
|
C00037773
|
Salvianolic acid C
|
No. 494 |
|
|||||
|
C00002770
|
Rosmarinic acid
|
CHEMBL66966
CHEMBL324842 CHEMBL1315100 CHEMBL2111558 |
48 / 35 / 38 | No. 749 |
|
|||
|
C00037774
|
Salvianolic acid D
|
No. 749 |
|
|||||
|
C00037499
|
Methyl rosmarinate
/ (+)-Methyl rosmarinate |
CHEMBL241405
CHEMBL1765650 |
6 / 5 / 4 | No. 749 |
|
|||
|
C00037775
|
Salvianolic acid E
|
No. 1276 |
|
|||||
|
C00002752
|
Isoferulic acid
|
CHEMBL233295
|
C008180
|
5 / 9 / 6 | 0 / 1 | No. 1366 | No. 6 |
|
|
C00030792
|
Montbretol
/ 6,12-Dihydroxyabieta-5,8,11,13-tetraen-7-one |
CHEMBL469670
|
No. 1418 |
|
||||
|
C00037776
|
Salvianolic acid F
|
CHEMBL464884
|
No. 1951 |
|
||||
|
C00031719
|
Danshenspiroketallactone
|
No. 2567 |
|
|||||
|
C00031402
|
Tanshinone II
/ Tanshinone IIA |
CHEMBL187266
|
44 / 56 / 79 | No. 3852 |
|
|||
|
C00042764
|
Neosalvianen
|
CHEMBL520209
|
No. 4117 |
|
||||
|
C00042927
|
Salvianan
|
No. 4117 |
|
|||||
|
C00042928
|
Salvianen
|
CHEMBL450365
|
No. 4117 |
|
||||
|
C00037059
|
Dimethyl lithospermate
|
CHEMBL2048505
|
6 / 5 / 4 | No. 4991 |
|
|||
|
C00046227
|
Oleoyl danshenxinkun A
/ (-)-Oleoyl danshenxinkun A |
CHEMBL473262
|
No. 5394 |
|
||||
|
C00046228
|
Oleoyl neocryptotanshinone
|
CHEMBL445779
|
No. 5394 |
|
||||
|
C00031401
|
Tanshinone I
/ Tanshinone A |
CHEMBL363535
|
C021751
|
26 / 35 / 57 | 84 / 6 | No. 5517 |
|
|
|
C00037777
|
Salvianolic acid G
/ (-)-Salvianolic acid G |
No. 6009 |
|
|||||
|
C00042926
|
Salviadione
|
CHEMBL449895
|
No. 7215 |
|
||||
|
C00037545
|
Neocryptotanshinone II
|
No. 8610 |
|
|||||
|
C00042146
|
5-(Methoxymethyl)-1H-pyrrole-2-carbaldehyde
|
No. 8926 |
|
Human Protein / Gene in interactions
81 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002752 C00002770 C00031401 C00031402 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002752 C00002770 C00031401 C00031402 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002770 C00031401 C00031402 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002752 C00031401 C00031402 | 7 / 3 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002770 C00031401 C00031402 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002770 C00031401 C00031402 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00002770 C00037059 C00037499 | 0 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002770 C00031401 C00031402 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002770 C00031401 C00031402 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002770 C00031401 C00031402 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002770 C00031401 C00031402 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002770 C00031401 C00031402 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002770 C00031401 C00031402 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002770 C00031401 C00031402 | 4 / 3 |
| P54132 | Bloom syndrome protein | Enzyme | C00002770 C00031401 | 1 / 2 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00031401 C00031402 | 5 / 5 |
| P23141 | Liver carboxylesterase 1 | Enzyme | C00031401 C00031402 | 0 / 0 |
| P08254 | Stromelysin-1 | M10A | C00037059 C00037499 | 1 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002770 C00002772 | 0 / 1 |
| P39900 | Macrophage metalloelastase | M10A | C00037059 C00037499 | 0 / 0 |
| O00748 | Cocaine esterase | Enzyme | C00031401 C00031402 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00037059 C00037499 | 2 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002770 C00031402 | 1 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00031401 C00031402 | 2 / 3 |
| Q12794 | Hyaluronidase-1 | Enzyme | C00002752 C00002770 | 1 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00031401 C00031402 | 1 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002770 C00031402 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002770 C00031402 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002770 C00031402 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00031401 C00031402 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002770 C00031402 | 2 / 2 |
| P15121 | Aldose reductase | Enzyme | C00002770 C00031402 | 0 / 0 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002770 C00002772 | 1 / 2 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002770 C00002772 | 3 / 3 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00031401 C00031402 | 7 / 37 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002770 C00031402 | 0 / 1 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002770 C00002772 | 1 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002770 C00031402 | 1 / 4 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002770 C00031402 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002770 C00031402 | 3 / 3 |
| P08253 | 72 kDa type IV collagenase | M10A | C00037059 C00037499 | 1 / 3 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002770 C00002772 | 0 / 0 |
| P45452 | Collagenase 3 | M10A | C00037059 C00037499 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00031402 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00031402 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002770 | 0 / 0 |
| P06401 | Progesterone receptor | NR3C3 | C00031402 | 0 / 1 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00031402 | 0 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00031402 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00031401 | 4 / 2 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00031402 | 2 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002752 | 1 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00031402 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002770 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002770 | 0 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002770 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002770 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002770 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00002770 | 0 / 0 |
| O14727 | Apoptotic protease-activating factor 1 | Unclassified protein | C00031402 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00031402 | 2 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00031402 | 3 / 4 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002770 | 3 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00031402 | 11 / 10 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002770 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00031401 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002770 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00002770 | 6 / 4 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002770 | 3 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002770 | 0 / 3 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00002770 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00031402 | 2 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00031401 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00031402 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00031402 | 1 / 2 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00002770 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002770 | 1 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002770 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00031401 | 0 / 3 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00002770 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00031401 | 1 / 1 |
84 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 37 | ACADVL, ACAD6, LCACD, VLCAD | acyl-CoA dehydrogenase, very long chain (EC:1.3.8.9) |
C00031401
|
| 2180 | ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 | acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) |
C00031401
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00031401
|
| 220 | ALDH1A3, ALDH1A6, ALDH6, MCOP8, RALDH3 | aldehyde dehydrogenase 1 family, member A3 (EC:1.2.1.5) |
C00031401
|
| 224 | ALDH3A2, ALDH10, FALDH, SLS | aldehyde dehydrogenase 3 family, member A2 (EC:1.2.1.3) |
C00031401
|
| 341 | APOC1 | apolipoprotein C-I |
C00031401
|
| 55937 | APOM, G3a, HSPC336, NG20, apo-M | apolipoprotein M |
C00031401
|
| 440 | ASNS, TS11 | asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) |
C00031401
|
| 445 | ASS1, ASS, CTLN1 | argininosuccinate synthase 1 (EC:6.3.4.5) |
C00031401
|
| 533 | ATP6V0B, ATP6F, HATPL, VMA16 | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) |
C00031401
|
| 529 | ATP6V1E1, ATP6E, ATP6E2, ATP6V1E, P31, Vma4 | ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 (EC:3.6.3.14) |
C00031401
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00031401
|
| 594 | BCKDHB, E1B, dJ279A18.1 | branched chain keto acid dehydrogenase E1, beta polypeptide (EC:1.2.4.4) |
C00031401
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00031401
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00031401
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00031401
|
| 10241 | CALCOCO2, NDP52 | calcium binding and coiled-coil domain 2 |
C00031401
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00031401
|
| 945 | CD33, SIGLEC-3, SIGLEC3, p67 | CD33 molecule |
C00031401
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00031401
|
| 4680 | CEACAM6, CD66c, CEAL, NCA | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
C00031401
|
| 1191 | CLU, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2 | clusterin |
C00031401
|
| 1291 | COL6A1, OPLL | collagen, type VI, alpha 1 |
C00031401
|
| 1474 | CST6 | cystatin E/M |
C00031401
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00031401
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00031401
|
| 25642 |
C00031401
|
||
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00031401
|
| 1633 | DCK | deoxycytidine kinase (EC:2.7.1.74) |
C00031401
|
| 8446 | DUSP11, PIR1 | dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (EC:3.1.3.16 3.1.3.48) |
C00031401
|
| 1847 | DUSP5, DUSP, HVH3 | dual specificity phosphatase 5 (EC:3.1.3.16 3.1.3.48) |
C00031401
|
| 8798 | DYRK4 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (EC:2.7.12.1) |
C00031401
|
| 8507 | ENC1, CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10 | ectodermal-neural cortex 1 (with BTB domain) |
C00031401
|
| 2067 | ERCC1, COFS4, RAD10, UV20 | excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) |
C00031401
|
| 2114 | ETS2, ETS2IT1 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
C00031401
|
| 2150 | F2RL1, GPR11, PAR2 | coagulation factor II (thrombin) receptor-like 1 |
C00031401
|
| 80308 | FLAD1, FAD1, FADS, RP11-307C12.7 | flavin adenine dinucleotide synthetase 1 (EC:2.7.7.2) |
C00031401
|
| 2353 | FOS, AP-1, C-FOS, p55 | FBJ murine osteosarcoma viral oncogene homolog |
C00031401
|
| 2629 | GBA, GBA1, GCB, GLUC | glucosidase, beta, acid (EC:3.2.1.45) |
C00031401
|
| 2670 | GFAP | glial fibrillary acidic protein |
C00031401
|
| 2886 | GRB7 | growth factor receptor-bound protein 7 |
C00031401
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00031401
|
| 8841 | HDAC3, HD3, RPD3, RPD3-2 | histone deacetylase 3 (EC:3.5.1.98) |
C00031401
|
| 3398 | ID2, GIG8, ID2A, ID2H, bHLHb26 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
C00031401
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00031401
|
| 3636 | INPPL1, OPSMD, SHIP2 | inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86) |
C00031401
|
| 3669 | ISG20, CD25, HEM45 | interferon stimulated exonuclease gene 20kDa (EC:3.1.13.1) |
C00031401
|
| 3655 | ITGA6, CD49f, ITGA6B, VLA-6 | integrin, alpha 6 |
C00031401
|
| 3684 | ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6 | integrin, alpha M (complement component 3 receptor 3 subunit) |
C00031401
|
| 4035 | LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5 | low density lipoprotein receptor-related protein 1 |
C00031401
|
| 4041 | LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2 | low density lipoprotein receptor-related protein 5 |
C00031401
|
| 7804 | LRP8, APOER2, HSZ75190, LRP-8, MCI1 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
C00031401
|
| 4129 | MAOB | monoamine oxidase B (EC:1.4.3.4) |
C00031401
|
| 4214 | MAP3K1, MAPKKK1, MEKK, MEKK_1, MEKK1, SRXY6 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) |
C00031401
|
| 4285 | MIPEP, HMIP, MIP | mitochondrial intermediate peptidase (EC:3.4.24.59) |
C00031401
|
| 4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00031401
|
| 4605 | MYBL2, B-MYB, BMYB | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
C00031401
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00031401
|
| 4632 | MYL1, MLC1F, MLC3F | myosin, light chain 1, alkali; skeletal, fast |
C00031401
|
| 8260 | NAA10, ARD1, ARD1A, ARD1P, DXS707, NATD, TE2 | N(alpha)-acetyltransferase 10, NatA catalytic subunit (EC:2.3.1.88) |
C00031401
|
| 4708 | NDUFB2, AGGG, CI-AGGG | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa (EC:1.6.5.3 1.6.99.3) |
C00031401
|
| 4723 | NDUFV1, CI-51K, CI51KD, UQOR1 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa (EC:1.6.5.3 1.6.99.3) |
C00031401
|
| 10763 | NES | nestin |
C00031401
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00031401
|
| 8856 | NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR | nuclear receptor subfamily 1, group I, member 2 |
C00031401
|
| 9970 | NR1I3, CAR, CAR1, MB67 | nuclear receptor subfamily 1, group I, member 3 |
C00031401
|
| 2908 | NR3C1, GCCR, GCR, GR, GRL | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
C00031401
|
| 44039 |
C00031401
|
||
| 143 | PARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193 | poly (ADP-ribose) polymerase family, member 4 (EC:2.4.2.30) |
C00031401
|
| 9159 | PCSK7, LPC, PC7, PC8, SPC7 | proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-) |
C00031401
|
| 5352 | PLOD2, LH2, TLH | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (EC:1.14.11.4) |
C00031401
|
| 24148 | PRPF6, ANT-1, ANT1, C20orf14, Prp6, SNRNP102, TOM, U5-102K, hPrp6 | pre-mRNA processing factor 6 |
C00031401
|
| 5693 | PSMB5, LMPX, MB1, X | proteasome (prosome, macropain) subunit, beta type, 5 (EC:3.4.25.1) |
C00031401
|
| 5708 | PSMD2, P97, RPN1, S2, TRAP2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 |
C00031401
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00031401
|
| 5796 | PTPRK, R-PTP-kappa | protein tyrosine phosphatase, receptor type, K (EC:3.1.3.48) |
C00031401
|
| 389 | RHOC, ARH9, ARHC, H9, RHOH9 | ras homolog family member C |
C00031401
|
| 6668 | SP2 | Sp2 transcription factor |
C00031401
|
| 352933 |
C00031401
|
||
| 7016 | TESK1 | testis-specific kinase 1 (EC:2.7.12.1) |
C00031401
|
| 7023 | TFAP4, AP-4, bHLHc41 | transcription factor AP-4 (activating enhancer binding protein 4) |
C00031401
|
| 7083 | TK1, TK2 | thymidine kinase 1, soluble (EC:2.7.1.21) |
C00031401
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00031401
|
| 10406 | WFDC2, EDDM4, HE4, WAP5, dJ461P17.6 | WAP four-disulfide core domain 2 |
C00031401
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (90)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #609135 | Aplastic anemia |
O14746
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 |
| #614466 | Coronary heart disease, susceptibility to, 6; chds6 |
P08254
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #601492 | Mucopolysaccharidosis, type ix; mps9 |
Q12794
|
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona |
P08253
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #602111 | Spondyloepimetaphyseal dysplasia, missouri type |
P45452
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (102)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P04637 (related) |
| H00024 | Prostate cancer |
O14746
(marker)
P10275 (related) |
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) P06401 (marker) |
| H00028 | Choriocarcinoma |
P03956
(related)
P04637 (related) P08253 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P08253 (related) P14780 (related) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00472 | Torg-Winchester syndrome |
P08253
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00479 | Metaphyseal dysplasias |
P14780
(related)
P45452 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00133 | Mucopolysaccharidosis type IX (MPS9) |
Q12794
(related)
|
| H00421 | Mucopolysaccharidosis (MPS) |
Q12794
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
10 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000647 | Amnesia |
C00002752
|
| D050197 | Atherosclerosis |
C00031401
|
| D001943 | Breast Neoplasms |
C00031401
|
| D005910 | Glioma |
C00031401
|
| D034381 | Hearing Loss |
C00031401
|
| D017379 | Hypertrophy, Left Ventricular |
C00031401
|
| D007951 | Leukemia, Myeloid |
C00031401
|
| D020324 | Amnesia, Anterograde |
C00002772
|
| D008107 | Liver Diseases |
C00002772
|
| D009203 | Myocardial Infarction |
C00002772
|