KNApSAcK Metabolite C00031401
Metabolite
KNApSAcK Entry
| id | C00031401 |
|---|---|
| Name | Tanshinone I / Tanshinone A |
| CAS RN | 568-73-0 |
| Standard InChI | InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3 |
| Standard InChI (Main Layer) | InChI=1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5517 |
Link
ChEMBL
| By standard InChI | CHEMBL363535 |
|---|---|
| By standard InChI Main Layer | CHEMBL363535 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C021751 |
|---|
Species
Summary
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Salvia glutinosa | 49211 | Lamiaceae | asterids | Viridiplantae |
| Salvia miltiorrhiza | 226208 | Lamiaceae | asterids | Viridiplantae |
| Salvia przewalskii | 342060 | Lamiaceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
26 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL363535 |
CHEMBL1738132
(1)
|
7 / 44 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL363535 |
CHEMBL1738312
(1)
|
0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL363535 |
CHEMBL2114784
(1)
|
1 / 1 |
| P06746 | DNA polymerase beta | Enzyme | CHEMBL363535 |
CHEMBL1614079
(1)
|
0 / 0 |
| O00748 | Cocaine esterase | Enzyme | CHEMBL363535 |
CHEMBL2341911
(1)
CHEMBL2341914
(1)
CHEMBL2341915 (1) |
0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | CHEMBL363535 |
CHEMBL1794585
(1)
|
0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL363535 |
CHEMBL1614067
(1)
|
1 / 2 |
| P11473 | Vitamin D3 receptor | NR1I1 | CHEMBL363535 |
CHEMBL1794311
(1)
|
2 / 3 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL363535 |
CHEMBL1794486
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL363535 |
CHEMBL2114843
(1)
CHEMBL2114780
(1)
|
0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | CHEMBL363535 |
CHEMBL2114807
(1)
|
4 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | CHEMBL363535 |
CHEMBL2114810
(1)
|
7 / 3 |
| Q9Y253 | DNA polymerase eta | Enzyme | CHEMBL363535 |
CHEMBL1794569
(1)
|
1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL363535 |
CHEMBL1794401
(1)
|
0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL363535 |
CHEMBL1738588
(1)
|
0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL363535 |
CHEMBL2341912
(1)
CHEMBL2341913
(1)
|
1 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL363535 |
CHEMBL1794483
(1)
|
0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | CHEMBL363535 |
CHEMBL1737991
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL363535 |
CHEMBL1614250
(1)
CHEMBL1614421
(1)
|
4 / 3 |
| P23141 | Liver carboxylesterase 1 | Enzyme | CHEMBL363535 |
CHEMBL2341916
(1)
|
0 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | CHEMBL363535 |
CHEMBL2160257
(1)
|
5 / 5 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL363535 |
CHEMBL1794536
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL363535 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL363535 |
CHEMBL1614364
(1)
|
1 / 1 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | CHEMBL363535 |
CHEMBL2114913
(1)
|
0 / 3 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL363535 |
CHEMBL2354287
(1)
|
1 / 1 |
CTD interaction (108)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C021751 | 37 |
ACADVL
ACAD6 LCACD VLCAD |
acyl-CoA dehydrogenase, very long chain (EC:1.3.8.9) | tanshinone results in increased expression of ACADVL mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 2180 |
ACSL1
ACS1 FACL1 FACL2 LACS LACS1 LACS2 |
acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3) | tanshinone results in increased expression of ACSL1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | tanshinone binds to and results in increased activity of AHR protein |
affects binding
/ increases activity |
protein |
21262253
|
| C021751 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | tanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA] |
increases expression
/ increases reaction |
mRNA |
21262253
|
| C021751 | 220 |
ALDH1A3
ALDH1A6 ALDH6 MCOP8 RALDH3 |
aldehyde dehydrogenase 1 family, member A3 (EC:1.2.1.5) | tanshinone results in decreased expression of ALDH1A3 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 224 |
ALDH3A2
ALDH10 FALDH SLS |
aldehyde dehydrogenase 3 family, member A2 (EC:1.2.1.3) | tanshinone results in decreased expression of ALDH3A2 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 341 |
APOC1
|
apolipoprotein C-I | tanshinone results in increased expression of APOC1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 55937 |
APOM
G3a HSPC336 NG20 apo-M |
apolipoprotein M | tanshinone results in increased expression of APOM mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 440 |
ASNS
TS11 |
asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) | tanshinone results in decreased expression of ASNS mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 445 |
ASS1
ASS CTLN1 |
argininosuccinate synthase 1 (EC:6.3.4.5) | tanshinone results in decreased expression of ASS1 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 533 |
ATP6V0B
ATP6F HATPL VMA16 |
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14) | tanshinone results in increased expression of ATP6V0B mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 529 |
ATP6V1E1
ATP6E ATP6E2 ATP6V1E P31 Vma4 |
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 (EC:3.6.3.14) | tanshinone results in increased expression of ATP6V1E1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | tanshinone results in increased expression of BAX protein |
increases expression
|
protein |
21699893
|
| C021751 | 594 |
BCKDHB
E1B dJ279A18.1 |
branched chain keto acid dehydrogenase E1, beta polypeptide (EC:1.2.4.4) | tanshinone results in decreased expression of BCKDHB mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | tanshinone results in decreased expression of BCL2 protein |
decreases expression
|
protein |
16009009
19885617 20369472 21699893 |
| C021751 | 330 |
BIRC3
AIP1 API2 CIAP2 HAIP1 HIAP1 MALT2 MIHC RNF49 c-IAP2 |
baculoviral IAP repeat containing 3 | tanshinone results in decreased expression of BIRC3 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | SB 203580 inhibits the reaction [tanshinone results in decreased expression of BIRC5 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
21165580
|
| C021751 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | tanshinone inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21165580
|
| C021751 | 332 |
BIRC5
API4 EPR-1 |
baculoviral IAP repeat containing 5 | tanshinone results in decreased expression of BIRC5 mRNA |
decreases expression
|
mRNA |
21165580
|
| C021751 | 10241 |
CALCOCO2
NDP52 |
calcium binding and coiled-coil domain 2 | tanshinone results in increased expression of CALCOCO2 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | tanshinone results in increased activity of CASP3 protein |
increases activity
|
protein |
21699893
|
| C021751 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | tanshinone results in increased expression of CASP3 protein |
increases expression
|
protein |
15849732
|
| C021751 | 945 |
CD33
SIGLEC-3 SIGLEC3 p67 |
CD33 molecule | tanshinone results in decreased expression of CD33 protein |
decreases expression
|
protein |
16009009
|
| C021751 | 1026 |
CDKN1A
CAP20 CDKN1 CIP1 MDA-6 P21 SDI1 WAF1 p21CIP1 |
cyclin-dependent kinase inhibitor 1A (p21, Cip1) | tanshinone results in increased expression of CDKN1A mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 4680 |
CEACAM6
CD66c CEAL NCA |
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | tanshinone results in decreased expression of CEACAM6 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 1191 |
CLU
APO-J APOJ CLI CLU1 CLU2 KUB1 NA1/NA2 SGP-2 SGP2 SP-40 TRPM-2 TRPM2 |
clusterin | tanshinone results in increased expression of CLU mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 1291 |
COL6A1
OPLL |
collagen, type VI, alpha 1 | tanshinone results in decreased expression of COL6A1 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 1474 |
CST6
|
cystatin E/M | tanshinone results in increased expression of CST6 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21262253
|
| C021751 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21262253
|
| C021751 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] |
increases expression
/ increases reaction |
mRNA |
21262253
|
| C021751 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] |
increases expression
/ increases reaction |
protein |
21262253
|
| C021751 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | tanshinone results in increased expression of CYP1A1 mRNA |
increases expression
|
mRNA |
15849732
16955220 21262253 |
| C021751 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | tanshinone results in increased expression of CYP1A1 protein |
increases expression
|
protein |
21262253
|
| C021751 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | Dactinomycin inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21262253
|
| C021751 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | resveratrol inhibits the reaction [tanshinone results in increased expression of CYP1A2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21262253
|
| C021751 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] |
increases expression
/ increases reaction |
mRNA |
21262253
|
| C021751 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | tanshinone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] |
increases expression
/ increases reaction |
protein |
21262253
|
| C021751 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | tanshinone results in increased expression of CYP1A2 mRNA |
increases expression
|
mRNA |
21262253
|
| C021751 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | tanshinone results in increased expression of CYP1A2 protein |
increases expression
|
protein |
21262253
|
| C021751 | 25642 | tanshinone results in decreased expression of CYP3A23/3A1 mRNA |
decreases expression
|
mRNA |
15849732
|
||
| C021751 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein] |
increases expression
/ increases reaction |
protein |
18805405
|
| C021751 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] |
affects reaction
/ increases expression |
protein |
18805405
|
| C021751 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] |
affects reaction
/ increases expression |
protein |
18805405
|
| C021751 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | tanshinone results in increased expression of CYP3A4 protein |
increases expression
|
protein |
18805405
|
| C021751 | 1633 |
DCK
|
deoxycytidine kinase (EC:2.7.1.74) | tanshinone results in increased expression of DCK mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 8446 |
DUSP11
PIR1 |
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (EC:3.1.3.16 3.1.3.48) | tanshinone results in increased expression of DUSP11 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 1847 |
DUSP5
DUSP HVH3 |
dual specificity phosphatase 5 (EC:3.1.3.16 3.1.3.48) | tanshinone results in increased expression of DUSP5 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 8798 |
DYRK4
|
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (EC:2.7.12.1) | tanshinone results in decreased expression of DYRK4 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 8507 |
ENC1
CCL28 ENC-1 KLHL35 KLHL37 NRPB PIG10 TP53I10 |
ectodermal-neural cortex 1 (with BTB domain) | tanshinone results in increased expression of ENC1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 2067 |
ERCC1
COFS4 RAD10 UV20 |
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | SB 203580 inhibits the reaction [tanshinone results in decreased expression of ERCC1 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
21165580
|
| C021751 | 2067 |
ERCC1
COFS4 RAD10 UV20 |
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence) | tanshinone results in decreased expression of ERCC1 mRNA |
decreases expression
|
mRNA |
21165580
|
| C021751 | 2114 |
ETS2
ETS2IT1 |
v-ets avian erythroblastosis virus E26 oncogene homolog 2 | tanshinone results in decreased expression of ETS2 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 2150 |
F2RL1
GPR11 PAR2 |
coagulation factor II (thrombin) receptor-like 1 | tanshinone results in increased expression of F2RL1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 80308 |
FLAD1
FAD1 FADS RP11-307C12.7 |
flavin adenine dinucleotide synthetase 1 (EC:2.7.7.2) | tanshinone results in increased expression of FLAD1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | tanshinone results in increased expression of FOS protein |
increases expression
|
protein |
16009009
|
| C021751 | 2629 |
GBA
GBA1 GCB GLUC |
glucosidase, beta, acid (EC:3.2.1.45) | tanshinone results in increased expression of GBA mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 2670 |
GFAP
|
glial fibrillary acidic protein | tanshinone results in increased expression of GFAP mRNA |
increases expression
|
mRNA |
16955220
|
| C021751 | 2670 |
GFAP
|
glial fibrillary acidic protein | tanshinone results in increased expression of GFAP protein |
increases expression
|
protein |
16955220
|
| C021751 | 2886 |
GRB7
|
growth factor receptor-bound protein 7 | tanshinone results in increased expression of GRB7 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | tanshinone results in decreased expression of GSTP1 mRNA |
decreases expression
|
mRNA |
21165580
|
| C021751 | 8841 |
HDAC3
HD3 RPD3 RPD3-2 |
histone deacetylase 3 (EC:3.5.1.98) | tanshinone results in increased expression of HDAC3 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 3398 |
ID2
GIG8 ID2A ID2H bHLHb26 |
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | tanshinone results in increased expression of ID2 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | tanshinone results in decreased expression of IL8 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 3636 |
INPPL1
OPSMD SHIP2 |
inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86) | tanshinone results in increased expression of INPPL1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 3669 |
ISG20
CD25 HEM45 |
interferon stimulated exonuclease gene 20kDa (EC:3.1.13.1) | tanshinone results in increased expression of ISG20 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 3655 |
ITGA6
CD49f ITGA6B VLA-6 |
integrin, alpha 6 | tanshinone results in decreased expression of ITGA6 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 3684 |
ITGAM
CD11B CR3A MAC-1 MAC1A MO1A SLEB6 |
integrin, alpha M (complement component 3 receptor 3 subunit) | tanshinone results in increased expression of ITGAM protein |
increases expression
|
protein |
16009009
|
| C021751 | 4035 |
LRP1
A2MR APOER APR CD91 IGFBP3R LRP LRP1A TGFBR5 |
low density lipoprotein receptor-related protein 1 | SB 203580 inhibits the reaction [tanshinone results in decreased expression of LRP1 mRNA] |
decreases expression
/ decreases reaction |
mRNA |
21165580
|
| C021751 | 4035 |
LRP1
A2MR APOER APR CD91 IGFBP3R LRP LRP1A TGFBR5 |
low density lipoprotein receptor-related protein 1 | tanshinone inhibits the reaction [Cisplatin results in increased expression of LRP1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
21165580
|
| C021751 | 4035 |
LRP1
A2MR APOER APR CD91 IGFBP3R LRP LRP1A TGFBR5 |
low density lipoprotein receptor-related protein 1 | tanshinone results in decreased expression of LRP1 mRNA |
decreases expression
|
mRNA |
21165580
|
| C021751 | 4041 |
LRP5
BMND1 EVR1 EVR4 HBM LR3 LRP7 OPPG OPS OPTA1 VBCH2 |
low density lipoprotein receptor-related protein 5 | tanshinone results in decreased expression of LRP5 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 7804 |
LRP8
APOER2 HSZ75190 LRP-8 MCI1 |
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor | tanshinone results in decreased expression of LRP8 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 4129 |
MAOB
|
monoamine oxidase B (EC:1.4.3.4) | tanshinone results in increased expression of MAOB mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 4214 |
MAP3K1
MAPKKK1 MEKK MEKK_1 MEKK1 SRXY6 |
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25) | tanshinone results in decreased expression of MAP3K1 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 4285 |
MIPEP
HMIP MIP |
mitochondrial intermediate peptidase (EC:3.4.24.59) | tanshinone results in decreased expression of MIPEP mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 4316 |
MMP7
MMP-7 MPSL1 PUMP-1 |
matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) | tanshinone results in decreased expression of MMP7 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 4605 |
MYBL2
B-MYB BMYB |
v-myb avian myeloblastosis viral oncogene homolog-like 2 | tanshinone results in increased expression of MYBL2 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 4609 |
MYC
MRTL MYCC bHLHe39 c-Myc |
v-myc avian myelocytomatosis viral oncogene homolog | tanshinone results in decreased expression of MYC protein |
decreases expression
|
protein |
16009009
21699893 |
| C021751 | 4632 |
MYL1
MLC1F MLC3F |
myosin, light chain 1, alkali; skeletal, fast | tanshinone results in increased expression of MYL1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 8260 |
NAA10
ARD1 ARD1A ARD1P DXS707 NATD TE2 |
N(alpha)-acetyltransferase 10, NatA catalytic subunit (EC:2.3.1.88) | tanshinone results in increased expression of NAA10 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 4708 |
NDUFB2
AGGG CI-AGGG |
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa (EC:1.6.5.3 1.6.99.3) | tanshinone results in increased expression of NDUFB2 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 4723 |
NDUFV1
CI-51K CI51KD UQOR1 |
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa (EC:1.6.5.3 1.6.99.3) | tanshinone results in increased expression of NDUFV1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 10763 |
NES
|
nestin | tanshinone results in decreased expression of NES mRNA |
decreases expression
|
mRNA |
16955220
|
| C021751 | 10763 |
NES
|
nestin | tanshinone results in decreased expression of NES protein |
decreases expression
|
protein |
16955220
|
| C021751 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | tanshinone results in increased expression of NOS3 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | NR1I2 protein promotes the reaction [tanshinone results in increased expression of CYP3A4 protein] |
increases expression
/ increases reaction |
protein |
18805405
|
| C021751 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | tanshinone results in increased activity of NR1I2 protein |
increases activity
|
protein |
18805405
|
| C021751 | 9970 |
NR1I3
CAR CAR1 MB67 |
nuclear receptor subfamily 1, group I, member 3 | NR1I3 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] |
affects reaction
/ increases expression |
protein |
18805405
|
| C021751 | 2908 |
NR3C1
GCCR GCR GR GRL |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | NR3C1 protein affects the reaction [tanshinone results in increased expression of CYP3A4 protein] |
affects reaction
/ increases expression |
protein |
18805405
|
| C021751 | 44039 | tanshinone results in decreased expression of PAK mRNA |
decreases expression
|
mRNA |
15849732
|
||
| C021751 | 143 |
PARP4
ADPRTL1 ARTD4 PARP-4 PARPL PH5P VAULT3 VPARP VWA5C p193 |
poly (ADP-ribose) polymerase family, member 4 (EC:2.4.2.30) | tanshinone results in increased expression of PARP4 mRNA |
increases expression
|
mRNA |
15849732
16955220 |
| C021751 | 9159 |
PCSK7
LPC PC7 PC8 SPC7 |
proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-) | tanshinone results in increased expression of PCSK7 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 5352 |
PLOD2
LH2 TLH |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (EC:1.14.11.4) | tanshinone results in decreased expression of PLOD2 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 24148 |
PRPF6
ANT-1 ANT1 C20orf14 Prp6 SNRNP102 TOM U5-102K hPrp6 |
pre-mRNA processing factor 6 | tanshinone results in decreased expression of PRPF6 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 5693 |
PSMB5
LMPX MB1 X |
proteasome (prosome, macropain) subunit, beta type, 5 (EC:3.4.25.1) | tanshinone results in increased expression of PSMB5 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 5708 |
PSMD2
P97 RPN1 S2 TRAP2 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | tanshinone results in increased expression of PSMD2 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | tanshinone inhibits the reaction [2-aminodiphenyl results in increased expression of PTGS2 protein] |
decreases reaction
/ increases expression |
protein |
22288910
|
| C021751 | 5796 |
PTPRK
R-PTP-kappa |
protein tyrosine phosphatase, receptor type, K (EC:3.1.3.48) | tanshinone results in decreased expression of PTPRK mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 389 |
RHOC
ARH9 ARHC H9 RHOH9 |
ras homolog family member C | tanshinone results in increased expression of RHOC mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 6668 |
SP2
|
Sp2 transcription factor | tanshinone results in decreased expression of SP2 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 352933 | tanshinone results in increased expression of SPS2 mRNA |
increases expression
|
mRNA |
15849732
|
||
| C021751 | 7016 |
TESK1
|
testis-specific kinase 1 (EC:2.7.12.1) | tanshinone results in increased expression of TESK1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 7023 |
TFAP4
AP-4 bHLHc41 |
transcription factor AP-4 (activating enhancer binding protein 4) | tanshinone results in decreased expression of TFAP4 mRNA |
decreases expression
|
mRNA |
15849732
|
| C021751 | 7083 |
TK1
TK2 |
thymidine kinase 1, soluble (EC:2.7.1.21) | tanshinone results in increased expression of TK1 mRNA |
increases expression
|
mRNA |
15849732
|
| C021751 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | tanshinone results in decreased expression of TP53 protein |
decreases expression
|
protein |
19885617
20369472 |
| C021751 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | tanshinone results in increased expression of TP53 protein |
increases expression
|
protein |
16009009
|
| C021751 | 10406 |
WFDC2
EDDM4 HE4 WAP5 dJ461P17.6 |
WAP four-disulfide core domain 2 | tanshinone results in increased expression of WFDC2 mRNA |
increases expression
|
mRNA |
15849732
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (35)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #609135 | Aplastic anemia |
O14746
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #133239 | Esophageal cancer |
P04637
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (57)
| KEGG | disease name | UniProt |
|---|---|---|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P04637 (related) |
| H00024 | Prostate cancer |
O14746
(marker)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
|
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
6 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D050197 | C021751 | Atherosclerosis |
therapeutic
|
20854809
|
|
| D001943 | C021751 | Breast Neoplasms |
therapeutic
|
15849732
19885617 |
|
| D005910 | C021751 | Glioma |
therapeutic
|
16955220
|
|
| D034381 | C021751 | Hearing Loss |
therapeutic
|
12760856
|
|
| D017379 | C021751 | Hypertrophy, Left Ventricular |
therapeutic
|
19662366
|
|
| D007951 | C021751 | Leukemia, Myeloid |
therapeutic
|
21699893
|