KCF-S cluster No. 5517 (2 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (2)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	6

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Cumulative family count

class name	count
Lamiaceae	6

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (2)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00031401	Tanshinone I / Tanshinone A	CHEMBL363535	C021751	26 / 35 / 57	84 / 6
C00031914	Isotanshinone II	CHEMBL227131

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P04637	Cellular tumor antigen p53	Transcription Factor	C00031401	7 / 37
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00031401	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00031401	1 / 1
P06746	DNA polymerase beta	Enzyme	C00031401	0 / 0
O00748	Cocaine esterase	Enzyme	C00031401	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00031401	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00031401	1 / 2
P11473	Vitamin D3 receptor	NR1I1	C00031401	2 / 3
P39748	Flap endonuclease 1	Enzyme	C00031401	0 / 0
O75496	Geminin	Unclassified protein	C00031401	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00031401	4 / 2
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00031401	7 / 3
Q9Y253	DNA polymerase eta	Enzyme	C00031401	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00031401	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00031401	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00031401	1 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00031401	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00031401	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00031401	4 / 3
P23141	Liver carboxylesterase 1	Enzyme	C00031401	0 / 0
O14746	Telomerase reverse transcriptase	Enzyme	C00031401	5 / 5
Q9UBT6	DNA polymerase kappa	Enzyme	C00031401	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00031401	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00031401	1 / 1
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00031401	0 / 3
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00031401	1 / 1

84 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
37	ACADVL, ACAD6, LCACD, VLCAD	acyl-CoA dehydrogenase, very long chain (EC:1.3.8.9)	C00031401
2180	ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2	acyl-CoA synthetase long-chain family member 1 (EC:6.2.1.3)	C00031401
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00031401
220	ALDH1A3, ALDH1A6, ALDH6, MCOP8, RALDH3	aldehyde dehydrogenase 1 family, member A3 (EC:1.2.1.5)	C00031401
224	ALDH3A2, ALDH10, FALDH, SLS	aldehyde dehydrogenase 3 family, member A2 (EC:1.2.1.3)	C00031401
341	APOC1	apolipoprotein C-I	C00031401
55937	APOM, G3a, HSPC336, NG20, apo-M	apolipoprotein M	C00031401
440	ASNS, TS11	asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4)	C00031401
445	ASS1, ASS, CTLN1	argininosuccinate synthase 1 (EC:6.3.4.5)	C00031401
533	ATP6V0B, ATP6F, HATPL, VMA16	ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (EC:3.6.3.14)	C00031401
529	ATP6V1E1, ATP6E, ATP6E2, ATP6V1E, P31, Vma4	ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 (EC:3.6.3.14)	C00031401
581	BAX, BCL2L4	BCL2-associated X protein	C00031401
594	BCKDHB, E1B, dJ279A18.1	branched chain keto acid dehydrogenase E1, beta polypeptide (EC:1.2.4.4)	C00031401
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00031401
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00031401
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00031401
10241	CALCOCO2, NDP52	calcium binding and coiled-coil domain 2	C00031401
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00031401
945	CD33, SIGLEC-3, SIGLEC3, p67	CD33 molecule	C00031401
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00031401
4680	CEACAM6, CD66c, CEAL, NCA	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	C00031401
1191	CLU, APO-J, APOJ, CLI, CLU1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2	clusterin	C00031401
1291	COL6A1, OPLL	collagen, type VI, alpha 1	C00031401
1474	CST6	cystatin E/M	C00031401
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00031401
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00031401
25642			C00031401
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00031401
1633	DCK	deoxycytidine kinase (EC:2.7.1.74)	C00031401
8446	DUSP11, PIR1	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) (EC:3.1.3.16 3.1.3.48)	C00031401
1847	DUSP5, DUSP, HVH3	dual specificity phosphatase 5 (EC:3.1.3.16 3.1.3.48)	C00031401
8798	DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 (EC:2.7.12.1)	C00031401
8507	ENC1, CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10	ectodermal-neural cortex 1 (with BTB domain)	C00031401
2067	ERCC1, COFS4, RAD10, UV20	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	C00031401
2114	ETS2, ETS2IT1	v-ets avian erythroblastosis virus E26 oncogene homolog 2	C00031401
2150	F2RL1, GPR11, PAR2	coagulation factor II (thrombin) receptor-like 1	C00031401
80308	FLAD1, FAD1, FADS, RP11-307C12.7	flavin adenine dinucleotide synthetase 1 (EC:2.7.7.2)	C00031401
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00031401
2629	GBA, GBA1, GCB, GLUC	glucosidase, beta, acid (EC:3.2.1.45)	C00031401
2670	GFAP	glial fibrillary acidic protein	C00031401
2886	GRB7	growth factor receptor-bound protein 7	C00031401
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00031401
8841	HDAC3, HD3, RPD3, RPD3-2	histone deacetylase 3 (EC:3.5.1.98)	C00031401
3398	ID2, GIG8, ID2A, ID2H, bHLHb26	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	C00031401
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00031401
3636	INPPL1, OPSMD, SHIP2	inositol polyphosphate phosphatase-like 1 (EC:3.1.3.86)	C00031401
3669	ISG20, CD25, HEM45	interferon stimulated exonuclease gene 20kDa (EC:3.1.13.1)	C00031401
3655	ITGA6, CD49f, ITGA6B, VLA-6	integrin, alpha 6	C00031401
3684	ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6	integrin, alpha M (complement component 3 receptor 3 subunit)	C00031401
4035	LRP1, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5	low density lipoprotein receptor-related protein 1	C00031401
4041	LRP5, BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2	low density lipoprotein receptor-related protein 5	C00031401
7804	LRP8, APOER2, HSZ75190, LRP-8, MCI1	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	C00031401
4129	MAOB	monoamine oxidase B (EC:1.4.3.4)	C00031401
4214	MAP3K1, MAPKKK1, MEKK, MEKK_1, MEKK1, SRXY6	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase (EC:2.7.11.25)	C00031401
4285	MIPEP, HMIP, MIP	mitochondrial intermediate peptidase (EC:3.4.24.59)	C00031401
4316	MMP7, MMP-7, MPSL1, PUMP-1	matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23)	C00031401
4605	MYBL2, B-MYB, BMYB	v-myb avian myeloblastosis viral oncogene homolog-like 2	C00031401
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00031401
4632	MYL1, MLC1F, MLC3F	myosin, light chain 1, alkali; skeletal, fast	C00031401
8260	NAA10, ARD1, ARD1A, ARD1P, DXS707, NATD, TE2	N(alpha)-acetyltransferase 10, NatA catalytic subunit (EC:2.3.1.88)	C00031401
4708	NDUFB2, AGGG, CI-AGGG	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa (EC:1.6.5.3 1.6.99.3)	C00031401
4723	NDUFV1, CI-51K, CI51KD, UQOR1	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa (EC:1.6.5.3 1.6.99.3)	C00031401
10763	NES	nestin	C00031401
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00031401
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00031401
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00031401
2908	NR3C1, GCCR, GCR, GR, GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	C00031401
44039			C00031401
143	PARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193	poly (ADP-ribose) polymerase family, member 4 (EC:2.4.2.30)	C00031401
9159	PCSK7, LPC, PC7, PC8, SPC7	proprotein convertase subtilisin/kexin type 7 (EC:3.4.21.-)	C00031401
5352	PLOD2, LH2, TLH	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (EC:1.14.11.4)	C00031401
24148	PRPF6, ANT-1, ANT1, C20orf14, Prp6, SNRNP102, TOM, U5-102K, hPrp6	pre-mRNA processing factor 6	C00031401
5693	PSMB5, LMPX, MB1, X	proteasome (prosome, macropain) subunit, beta type, 5 (EC:3.4.25.1)	C00031401
5708	PSMD2, P97, RPN1, S2, TRAP2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	C00031401
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00031401
5796	PTPRK, R-PTP-kappa	protein tyrosine phosphatase, receptor type, K (EC:3.1.3.48)	C00031401
389	RHOC, ARH9, ARHC, H9, RHOH9	ras homolog family member C	C00031401
6668	SP2	Sp2 transcription factor	C00031401
352933			C00031401
7016	TESK1	testis-specific kinase 1 (EC:2.7.12.1)	C00031401
7023	TFAP4, AP-4, bHLHc41	transcription factor AP-4 (activating enhancer binding protein 4)	C00031401
7083	TK1, TK2	thymidine kinase 1, soluble (EC:2.7.1.21)	C00031401
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00031401
10406	WFDC2, EDDM4, HE4, WAP5, dJ461P17.6	WAP four-disulfide core domain 2	C00031401

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions