PCIDB

Baccharis dracunculifolia

Species

KNApSAcK Entry

Organism name Baccharis dracunculifolia
Genus Baccharis
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Baccharis dracunculifolia
Linked NCBI taxonomy ID 72900
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (12)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00029831 External link 512 Bisacumol
/ (+)-Bisacumol
No. 456 No. 38
C00012483 External link 512 Betula pubescens
/ Caryophyllene oxide
/ trans-Caryophyllene oxide
/ beta-Caryophyllene epoxide
/ (-)-Epoxydihydrocaryophyllene
/ 6,7-Epoxy-3(15)-caryophyllene
/ (-)-beta-Caryophyllene epoxide
/ 4beta,5alpha-Epoxycaryophyllene
/ Caryophyllene 4beta,5alpha-epoxide
CHEMBL399036
CHEMBL508894
CHEMBL479134
CHEMBL1513806
CHEMBL1553274
3 / 1 / 3 No. 500
C00030934 External link 512 p-Cymene-2,3-diol
No. 969 No. 35
C00000156 External link 512 Carvacrol
CHEMBL281202
C073316
10 / 6 / 1 4 / 2 No. 969 No. 35
C00000155 External link 512 Thymol
CHEMBL29411
D013943
9 / 17 / 14 12 / 0 No. 969 No. 35
C00029535 External link 512 Isocarvacrol
/ 4-Isopropyl-2-methylphenol
No. 969 No. 35
C00000149 External link 512 Spathulenol
CHEMBL518542
CHEMBL1774433
C013258
No. 1603
C00029766 External link 512 Baccharisketone
No. 1899
C00022794 External link 512 Artepillin C
CHEMBL456309
C102259
6 / 1 / 0 No. 4836
C00022793 External link 512 Drupanin
CHEMBL464997
6 / 1 / 0 No. 5388
C00029475 External link 512 3,4,3',4'-Tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl
No. 6688
C00010977 External link 512 Carquejol acetate
No. 8701

Human Protein / Gene in interactions

21 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000155 C00000156 3 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00022793 C00022794 1 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000155 C00000156 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00022793 C00022794 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000155 C00000156 5 / 1
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00022793 C00022794 1 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme C00000155 C00000156 0 / 0
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00022793 C00022794 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00022793 C00022794 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000155 C00000156 0 / 0
O75762 Transient receptor potential cation channel subfamily A member 1 Unclassified protein C00000155 C00000156 1 / 0
P15121 Aldose reductase Enzyme C00022793 C00022794 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000155 C00000156 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000156 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000156 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00012483 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00012483 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00012483 0 / 1
P02545 Prelamin-A/C Unclassified protein C00000155 11 / 10
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000155 0 / 3
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000156 0 / 0

14 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000155 C00000156
162514 TRPV3, OLMS, VRL3 transient receptor potential cation channel, subfamily V, member 3 C00000155 C00000156
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000155
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000156
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00000155
581 BAX, BCL2L4 BCL2-associated X protein C00000155
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000155
8989 TRPA1, ANKTM1, FEPS transient receptor potential cation channel, subfamily A, member 1 C00000156
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000155
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000155
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000155
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000155
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000155
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000155

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#609535 Drug metabolism, poor, cyp2c19-related P33261
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615040 Episodic pain syndrome, familial, 1; feps1 O75762
#143500 Gilbert syndrome P22309
P22310
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545

KEGG DISEASE (17)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)

Diseases related to CTD interactions

2 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003866 Depressive Disorder C00000156
D010146 Pain C00000156