Origanum vulgare
Species
KNApSAcK Entry
| Organism name | Origanum vulgare |
|---|---|
| Genus | Origanum |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Origanum vulgare |
|---|---|
| Linked NCBI taxonomy ID | 39352 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Natural Activity
List (32)
| Species | Activity |
|---|---|
| Origanum vulgare L. | Analgesic |
| Origanum vulgare L. | Antialzheimeran |
| Origanum vulgare L. | Antiarthritic |
| Origanum vulgare L. | Antibacterial |
| Origanum vulgare L. | Anticancer |
| Origanum vulgare L. | Antiinflammatory |
| Origanum vulgare L. | Antimutagenic |
| Origanum vulgare L. | Antioxidant |
| Origanum vulgare L. | Antipyretic |
| Origanum vulgare L. | Antiseptic |
| Origanum vulgare L. | Antispasmodic |
| Origanum vulgare L. | Carminative |
| Origanum vulgare L. | Choleretic |
| Origanum vulgare L. | COX-2 Inhibitor |
| Origanum vulgare L. | Decongestant |
| Origanum vulgare L. | Diaphoretic |
| Origanum vulgare L. | Digestive |
| Origanum vulgare L. | Diuretic |
| Origanum vulgare L. | Emmenagogue |
| Origanum vulgare L. | Expectorant |
| Origanum vulgare L. | Fungicide |
| Origanum vulgare L. | Laxative |
| Origanum vulgare L. | Narcotic |
| Origanum vulgare L. | Nervine |
| Origanum vulgare L. | Orexigenic |
| Origanum vulgare L. | Pectoral |
| Origanum vulgare L. | Propecic |
| Origanum vulgare L. | Sedative |
| Origanum vulgare L. | Stimulant |
| Origanum vulgare L. | Stomachic |
| Origanum vulgare L. | Tonic |
| Origanum vulgare L. | Vermicide |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00000983
|
Naringin
|
CHEMBL451532
CHEMBL451512 CHEMBL1742953 CHEMBL1970019 |
C005274
|
18 / 12 / 6 | 12 / 4 | No. 48 | No. 14 |
|
|
C00000156
|
Carvacrol
|
CHEMBL281202
|
C073316
|
10 / 6 / 1 | 4 / 2 | No. 969 | No. 35 |
|
|
C00010934
|
p-Menth-3-en-1-ol
|
No. 2215 |
|
|||||
|
C00036174
|
Nepetoidin A
|
No. 2442 |
|
|||||
|
C00036175
|
Nepetoidin B
|
CHEMBL2335274
|
No. 2442 |
|
Human Protein / Gene in interactions
25 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000156 C00000983 | 3 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000156 C00000983 | 5 / 1 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00000156 C00000983 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000983 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000156 | 0 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00000983 | 1 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000156 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000983 | 0 / 0 |
| P46721 | Solute carrier organic anion transporter family member 1A2 | Unclassified protein | C00000983 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000156 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00000983 | 1 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00000983 | 1 / 2 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00000983 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00000983 | 1 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00000983 | 2 / 2 |
| O75762 | Transient receptor potential cation channel subfamily A member 1 | Unclassified protein | C00000156 | 1 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000156 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00000156 | 0 / 0 |
| P61088 | Ubiquitin-conjugating enzyme E2 N | Enzyme | C00000983 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000983 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000156 | 0 / 0 |
| Q9Y251 | Heparanase | Enzyme | C00000983 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000983 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000983 | 1 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00000983 | 1 / 1 |
15 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00000156
C00000983
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00000983
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00000983
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000983
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00000983
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000983
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00000983
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00000983
|
| 8772 | FADD, MORT1 | Fas (TNFRSF6)-associated via death domain |
C00000983
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00000983
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00000983
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00000983
|
| 8989 | TRPA1, ANKTM1, FEPS | transient receptor potential cation channel, subfamily A, member 1 |
C00000156
|
| 162514 | TRPV3, OLMS, VRL3 | transient receptor potential cation channel, subfamily V, member 3 |
C00000156
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00000156
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (13)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #615040 | Episodic pain syndrome, familial, 1; feps1 |
O75762
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
KEGG DISEASE (6)
| KEGG | name | UniProt |
|---|---|---|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
Diseases related to CTD interactions
6 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D058186 | Acute Kidney Injury |
C00000983
|
| D056486 | Drug-Induced Liver Injury |
C00000983
|
| D009203 | Myocardial Infarction |
C00000983
|
| D002583 | Uterine Cervical Neoplasms |
C00000983
|
| D003866 | Depressive Disorder |
C00000156
|
| D010146 | Pain |
C00000156
|