Species

KNApSAcK Entry

Organism name Rhododendron spp.
Genus Rhododendron
Family Ericaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Rhododendron
Linked NCBI taxonomy ID 4346
Linked level genus

Family

Family in NCBI taxonomy Ericaceae
ID 4345

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002378 External link 512 Cyanin
/ Cyanidin 3,5-diglucoside
No. 1 No. 15
C00006650 External link 512 Cyanidin 3-arabinoside
No. 2 No. 15
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00006696 External link 512 Delphinidin 3-arabinoside
No. 2 No. 15
C00004637 External link 512 Caryatin
/ 3,5-Di-O-Methylquercetin
/ 2-(3,4-Dihydroxyphenyl)-7-hydroxy-3,5-dimethoxy-4H-1-benzopyran-4-one
CHEMBL2043331
No. 3 No. 15
C00004760 External link 512 Myricetin 5-methyl ether
No. 3 No. 15
C00004633 External link 512 Azaleatin
CHEMBL470848
2 / 2 / 1 No. 3 No. 15
C00008239 External link 512 Farrerol
/ (-)-Farrerol
CHEMBL507611
CHEMBL1224582
C015881
No. 25 No. 14
C00007992 External link 512 Asebotin
CHEMBL490513
C002548
No. 36 No. 13
C00000990 External link 512 Phloridzin
/ Phloretin 2'-glucoside
CHEMBL45266
CHEMBL245067
CHEMBL1320052
CHEMBL1524370
CHEMBL2096900
D010695
16 / 15 / 14 3 / 7 No. 36 No. 13
C00000677 External link 512 Distylin
/ Dihydroquercetin
/ (2R,3R)-Taxifolin
CHEMBL66
CHEMBL9249
CHEMBL337309
CHEMBL1492383
C003377
65 / 41 / 37 29 / 1 No. 42 No. 14
C00007234 External link 512 Katuranin
/ (+)-Aromadendrin
/ (+)-Dihydrokaempferol
/ (2R,3R)-2,3-Dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL9323
CHEMBL1933859
C080220
4 / 3 / 3 No. 42 No. 14
C00000938 External link 512 Ampelopsin
/ Dihydromyricetin
/ (2R,3R)-3,5,7,3',4',5'-Hexahydroxyflavanone
CHEMBL2048508
C106407
6 / 5 / 4 1 / 0 No. 42 No. 14
C00008241 External link 512 Farrerol 5,7-di-O-glucoside
No. 48 No. 14
C00000940 External link 512 Asebogenin
CHEMBL253257
No. 90 No. 13
C00003434 External link 512 Grayanotoxin I
CHEMBL169387
CHEMBL490705
CHEMBL1971906
C001311
No. 320 No. 45
C00002669 External link 512 Pyrocatechuic acid
/ o-Pyrocatechuic acid
/ 2,3-Dihydroxybenzoic acid
CHEMBL1432
C009135
12 / 6 / 5 1 / 4 No. 817 No. 81

Human Protein / Gene in interactions

90 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08253 72 kDa type IV collagenase M10A C00000677 C00000938 C00002669 1 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000677 C00000990 C00005374 0 / 0
P03956 Interstitial collagenase M10A C00000677 C00000938 C00002669 0 / 1
P08254 Stromelysin-1 M10A C00000677 C00000938 C00002669 1 / 0
P14780 Matrix metalloproteinase-9 M10A C00000677 C00000938 C00002669 2 / 2
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000677 C00002669 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00002669 C00005374 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000677 C00005374 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000677 C00000990 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000677 C00000990 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000677 C00000990 2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000677 C00000990 3 / 3
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000677 C00005374 0 / 0
P45452 Collagenase 3 M10A C00000677 C00000938 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000677 C00007234 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000677 C00005374 1 / 1
P39900 Macrophage metalloelastase M10A C00000677 C00000938 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000677 C00000990 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00000677 C00005374 0 / 0
O75496 Geminin Unclassified protein C00000677 C00007234 0 / 0
P39748 Flap endonuclease 1 Enzyme C00000677 C00005374 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000677 C00005374 1 / 1
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00000677 C00007234 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000677 C00000990 0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00007234 2 / 2
P10828 Thyroid hormone receptor beta NR1A2 C00000990 3 / 1
P07237 Protein disulfide-isomerase Enzyme C00005374 0 / 0
P04792 Heat shock protein beta-1 Unclassified protein C00004633 2 / 1
P54132 Bloom syndrome protein Enzyme C00000677 1 / 2
P41145 Kappa-type opioid receptor Opioid receptor C00000677 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00005374 0 / 0
P16581 E-selectin Adhesion C00002669 0 / 0
Q99808 Equilibrative nucleoside transporter 1 Nucleoside uniporter C00000990 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000677 0 / 0
Q9HAS3 Solute carrier family 28 member 3 Unclassified protein C00000990 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000990 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00000677 0 / 1
Q9NY91 Low affinity sodium-glucose cotransporter Unclassified protein C00000990 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000677 0 / 0
P15121 Aldose reductase Enzyme C00005374 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000677 0 / 0
P22894 Neutrophil collagenase M10A C00002669 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005374 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000677 1 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein C00000677 0 / 0
P02768 Serum albumin Secreted protein C00002669 0 / 0
P06746 DNA polymerase beta Enzyme C00000677 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00000677 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000677 0 / 0
P56817 Beta-secretase 1 A1A C00000677 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000677 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000677 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00000677 0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00000677 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000677 1 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000677 5 / 2
P35372 Mu-type opioid receptor Opioid receptor C00000677 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000677 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000677 0 / 0
P14151 L-selectin Adhesion C00002669 0 / 0
P16109 P-selectin Adhesion C00002669 1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00000677 2 / 0
Q99700 Ataxin-2 Unclassified protein C00002669 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000677 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000677 4 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00004633 0 / 0
O00337 Sodium/nucleoside cotransporter 1 Unclassified protein C00000990 0 / 0
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
P31639 Sodium/glucose cotransporter 2 Glucose C00000990 1 / 1
O43868 Sodium/nucleoside cotransporter 2 Unclassified protein C00000990 0 / 0
P24298 Alanine aminotransferase 1 Enzyme C00000677 0 / 0
P13866 Sodium/glucose cotransporter 1 Glucose C00000990 1 / 1
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000677 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000677 0 / 0
O00255 Menin Unclassified protein C00000677 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000677 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00000677 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00000677 1 / 4
Q05513 Protein kinase C zeta type Iota C00000677 0 / 0
Q04759 Protein kinase C theta type Delta C00000677 0 / 1
Q02156 Protein kinase C epsilon type Eta C00000677 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000677 0 / 0
P17252 Protein kinase C alpha type Alpha C00000677 0 / 0
Q05655 Protein kinase C delta type Delta C00000677 0 / 0
P05129 Protein kinase C gamma type Alpha C00000677 1 / 1
P05771 Protein kinase C beta type Alpha C00000677 0 / 0
P24723 Protein kinase C eta type Eta C00000677 1 / 0
P41743 Protein kinase C iota type Iota C00000677 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00000677 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00005374 0 / 0

36 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
4363 ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 C00000677
335 APOA1 apolipoprotein A-I C00000677
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00000677
8900 CCNA1 cyclin A1 C00000677
993 CDC25A, CDC25A2 cell division cycle 25A (EC:3.1.3.48) C00000677
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00000677
1630 DCC, CRC18, CRCR1, IGDCC1, MRMV1 deleted in colorectal carcinoma C00000677
1950 EGF, HOMG4, URG epidermal growth factor C00000677
8817 FGF18, FGF-18, ZFGF5 fibroblast growth factor 18 C00000677
2248 FGF3, HBGF-3, INT2 fibroblast growth factor 3 C00000677
2621 GAS6, AXLLG, AXSF growth arrest-specific 6 C00000677
9518 GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB growth differentiation factor 15 C00000677
2944 GSTM1, GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1 glutathione S-transferase mu 1 (EC:2.5.1.18) C00000677
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000677
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000677
3458 IFNG, IFG, IFI interferon, gamma C00000677
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00000677
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00000677
4547 MTTP, ABL, MTP microsomal triglyceride transfer protein C00000677
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000677
1728 NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) C00000677
5155 PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis platelet-derived growth factor beta polypeptide C00000677
5921 RASA1, CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP RAS p21 protein activator (GTPase activating protein) 1 C00000677
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000677
7187 TRAF3, CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1 TNF receptor-associated factor 3 C00000677
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000677
7498 XDH, XO, XOR xanthine dehydrogenase (EC:1.17.1.4 1.17.3.2) C00000677
7507 XPA, XP1, XPAC xeroderma pigmentosum, complementation group A C00000677
7518 XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 C00000677
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00002669
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005374
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005374
8877 SPHK1, SPHK sphingosine kinase 1 (EC:2.7.1.91) C00000938
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00000990
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000990
6523 SLC5A1, D22S675, NAGT, SGLT1 solute carrier family 5 (sodium/glucose cotransporter), member 1 C00000990

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (51)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#210900 Bloom syndrome; blm P54132
#118300 Charcot-marie-tooth disease and deafness Q01453
#606595 Charcot-marie-tooth disease, axonal, type 2f; cmt2f P04792
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#133239 Esophageal cancer P18054
#600274 Frontotemporal dementia; ftd P10636
#606824 Glucose/galactose malabsorption; ggm P13866
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#603932 Intervertebral disc disease; idd P14780
#601626 Leukemia, acute myeloid; aml P36888
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#608634 Neuronopathy, distal hereditary motor, type iib; hmn2b P04792
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#233100 Renal glucosuria; glys1 P31639
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#602111 Spondyloepimetaphyseal dysplasia, missouri type P45452
#601367 Stroke, ischemic P16109
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (43)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00856 Distal hereditary motor neuropathies (dHMN) P04792 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00479 Metaphyseal dysplasias P14780 (related)
P45452 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00005 Chronic lymphocytic leukemia (CLL) P28907 (marker)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00264 Charcot-Marie-Tooth disease (CMT) Q01453 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

13 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006461 Hemolysis C00000677
D058186 Acute Kidney Injury C00002669
D034381 Hearing Loss C00002669
D007674 Kidney Diseases C00002669
D015837 Vestibular Diseases C00002669
D010146 Pain C00005374
D002418 Cattle Diseases C00000990
D003921 Diabetes Mellitus, Experimental C00000990
D006029 Glycosuria C00000990
D006943 Hyperglycemia C00000990
D007003 Hypoglycemia C00000990
D007662 Ketosis C00000990
D015431 Weight Loss C00000990