PCIDB

KNApSAcK Metabolite C00000990

Metabolite

KNApSAcK Entry

id C00000990
Name Phloridzin / Phloretin 2'-glucoside
CAS RN 60-81-1
Standard InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16?,18-,19+,20?,21-/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2

Cluster

Phytochemical cluster No. 13
KCF-S cluster No. 36

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL45266 CHEMBL245067 CHEMBL1320052 CHEMBL1524370 CHEMBL2096900

KEGG

By LinkDB C01604

CTD

By CAS RN D010695

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P13866 Sodium/glucose cotransporter 1 Glucose CHEMBL245067 CHEMBL2096900 CHEMBL809058 (2) CHEMBL892512 (1)
CHEMBL947998 (1) CHEMBL975174 (1)
CHEMBL1040744 (1) CHEMBL1068135 (1)
CHEMBL1070173 (1) CHEMBL1108921 (1)
CHEMBL1655515 (1) CHEMBL1763177 (1)
CHEMBL1821170 (1) CHEMBL2051077 (1)
CHEMBL2162521 (1) CHEMBL2174861 (1)
1 / 1
P31639 Sodium/glucose cotransporter 2 Glucose CHEMBL245067 CHEMBL892513 (1) CHEMBL947997 (1)
CHEMBL1005353 (1) CHEMBL977366 (1)
CHEMBL977369 (1) CHEMBL961709 (2)
CHEMBL1068136 (1) CHEMBL1070174 (1)
CHEMBL1108920 (1) CHEMBL1655514 (1)
CHEMBL1763176 (1) CHEMBL2051076 (1)
CHEMBL2162522 (1) CHEMBL2174862 (1)
1 / 1
O00337 Sodium/nucleoside cotransporter 1 Unclassified protein CHEMBL245067 CHEMBL940635 (1)
0 / 0
Q9HAS3 Solute carrier family 28 member 3 Unclassified protein CHEMBL245067 CHEMBL957102 (1)
0 / 0
Q99808 Equilibrative nucleoside transporter 1 Nucleoside uniporter CHEMBL245067 CHEMBL957103 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1524370 CHEMBL1613776 (1)
3 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1320052 CHEMBL1614027 (1)
0 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL245067 CHEMBL1738606 (1)
0 / 0
Q9NY91 Low affinity sodium-glucose cotransporter Unclassified protein CHEMBL245067 CHEMBL1821169 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1320052 CHEMBL1524370 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL245067 CHEMBL1524370 CHEMBL1614038 (2)
2 / 2
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1320052 CHEMBL1613777 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL245067 CHEMBL1524370 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL2051079 (1) CHEMBL2051080 (1)
CHEMBL2051190 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1524370 CHEMBL1614421 (1)
4 / 3
O43868 Sodium/nucleoside cotransporter 2 Unclassified protein CHEMBL245067 CHEMBL940636 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1524370 CHEMBL1613914 (1)
0 / 0

CTD interaction (6)

compound gene gene name gene description interaction interaction type form reference
pmid
D010695 213 ALB
PRO0883
PRO0903
PRO1341
albumin Phlorhizin inhibits the reaction [Glucose results in decreased uptake of ALB protein] decreases reaction
/ decreases uptake
protein 16313995
D010695 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Phlorhizin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS3 mRNA] decreases reaction
/ increases expression
mRNA 20021702
D010695 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Phlorhizin results in decreased expression of NOS3 mRNA decreases expression
mRNA 20021702
D010695 6523 SLC5A1
D22S675
NAGT
SGLT1
solute carrier family 5 (sodium/glucose cotransporter), member 1 Phlorhizin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] decreases reaction
/ increases uptake
protein 17288452
17983207
D010695 6523 SLC5A1
D22S675
NAGT
SGLT1
solute carrier family 5 (sodium/glucose cotransporter), member 1 Phlorhizin inhibits the reaction [[Sodium co-treated with SLC5A1 protein] results in increased uptake of methylglucoside] affects cotreatment
/ decreases reaction
/ increases uptake
protein 16300400
D010695 6523 SLC5A1
D22S675
NAGT
SGLT1
solute carrier family 5 (sodium/glucose cotransporter), member 1 SLC5A1 protein binds to Phlorhizin affects binding
protein 17983207

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#600274 Frontotemporal dementia; ftd P10636
#606824 Glucose/galactose malabsorption; ggm P13866
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#233100 Renal glucosuria; glys1 P31639
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (14)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

7 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002418 D010695 Cattle Diseases marker/mechanism
6497141
D003921 D010695 Diabetes Mellitus, Experimental therapeutic
22538082
D006029 D010695 Glycosuria marker/mechanism
6501647
6501648
D006943 D010695 Hyperglycemia therapeutic
1829330
16123366
22538082
D007003 D010695 Hypoglycemia marker/mechanism
6497141
D007662 D010695 Ketosis marker/mechanism
6497141
D015431 D010695 Weight Loss marker/mechanism
22538082