| Organism name | Symplocos lancifolia | 
|---|---|
| Genus | Symplocos | 
| Family | Symplocaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Symplocos lancifolia | 
|---|---|
| Linked NCBI taxonomy ID | 239704 | 
| Linked level | species | 
| Family in NCBI taxonomy | Symplocaceae | 
|---|---|
| ID | 20019 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | asterids | 
|---|---|
| ID | 71274 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00000990   | Phloridzin / Phloretin 2'-glucoside | CHEMBL45266 CHEMBL245067 CHEMBL1320052 CHEMBL1524370 CHEMBL2096900 | D010695 | 16 / 15 / 14 | 3 / 7 | No. 36 | No. 13 |   | 
| C00007190   | (+)-Pinoresinol | CHEMBL267963 CHEMBL487611 CHEMBL460862 | C103298 | 7 / 5 / 6 | No. 38 | No. 21 |   | |
| C00002631   | (+)-Lirioresinol B / (+)-Syringaresinol | CHEMBL361362 CHEMBL402653 | C042192 | 1 / 0 / 0 | No. 38 | No. 21 |   | |
| C00007204   | Isolariciresinol / (+)-Isolariciresinol | CHEMBL399512 CHEMBL1760593 | C060284 | 2 / 1 / 1 | No. 406 |   | ||
| C00002591   | (-)-Cubebin / beta-Cubebin / (-)-beta-Cubebin / (8R,8'R,9S)-Cubebin | CHEMBL182001 CHEMBL399831 | C433065 | 2 / 1 / 1 | 0 / 2 | No. 629 | No. 21 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000990 C00002591 C00007204 | 0 / 1 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002591 C00007204 | 1 / 0 | 
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000990 | 0 / 0 | 
| O00337 | Sodium/nucleoside cotransporter 1 | Unclassified protein | C00000990 | 0 / 0 | 
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00007190 | 0 / 0 | 
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00007190 | 0 / 3 | 
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00007190 | 0 / 0 | 
| Q9HAS3 | Solute carrier family 28 member 3 | Unclassified protein | C00000990 | 0 / 0 | 
| Q99808 | Equilibrative nucleoside transporter 1 | Nucleoside uniporter | C00000990 | 0 / 0 | 
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000990 | 3 / 1 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000990 | 0 / 1 | 
| P11387 | DNA topoisomerase 1 | Isomerase | C00002631 | 0 / 0 | 
| P31639 | Sodium/glucose cotransporter 2 | Glucose | C00000990 | 1 / 1 | 
| Q9NY91 | Low affinity sodium-glucose cotransporter | Unclassified protein | C00000990 | 0 / 0 | 
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00007190 | 5 / 3 | 
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000990 | 3 / 3 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000990 | 2 / 2 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00007190 | 0 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000990 | 1 / 1 | 
| P13866 | Sodium/glucose cotransporter 1 | Glucose | C00000990 | 1 / 1 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000990 | 4 / 3 | 
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00007190 | 0 / 0 | 
| O43868 | Sodium/nucleoside cotransporter 2 | Unclassified protein | C00000990 | 0 / 0 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000990 | 0 / 0 | 
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00007190 | 0 / 0 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin | C00000990 | 
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | C00000990 | 
| 6523 | SLC5A1, D22S675, NAGT, SGLT1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | C00000990 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency | Q99714 | 
| %606641 | Body mass index; bmi | P37231 | 
| #609338 | Carotid intimal medial thickness 1 | P37231 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #137800 | Glioma susceptibility 1; glm1 | P37231 | 
| #606824 | Glucose/galactose malabsorption; ggm | P13866 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 | P37231 | 
| #300705 | Mental retardation, x-linked 17; mrx17 | Q99714 | 
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 | Q99714 | 
| #601665 | Obesity | P37231 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #172700 | Pick disease of brain | P10636 | 
| #233100 | Renal glucosuria; glys1 | P31639 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth | P10828 | 
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth | P10828 | 
| #145650 | Thyroid hormone resistance, selective pituitary; prth | P10828 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00036 | Osteosarcoma | P08684
                            (marker) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H00249 | Thyroid hormone resistance syndrome | P10828
                            (related) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H01261 | Congenital glucose-galactose malabsorption (GGM) | P13866
                            (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H01126 | Familial renal glucosuria (FRG) | P31639
                            (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00017 | Esophageal cancer | P35354
                            (related) | 
| H00025 | Penile cancer | P35354
                            (related) | 
| H00046 | Cholangiocarcinoma | P35354
                            (related) | 
| H00032 | Thyroid cancer | P37231
                            (related) | 
| H00409 | Type II diabetes mellitus | P37231
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P37231
                            (related) | 
| H00480 | Non-syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00658 | Syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency | Q99714
                            (related) | 
| MESH or OMIM | name | KNApSAcK metabolite | 
|---|---|---|
| D004487 | Edema | C00002591 | 
| D010146 | Pain | C00002591 | 
| D002418 | Cattle Diseases | C00000990 | 
| D003921 | Diabetes Mellitus, Experimental | C00000990 | 
| D006029 | Glycosuria | C00000990 | 
| D006943 | Hyperglycemia | C00000990 | 
| D007003 | Hypoglycemia | C00000990 | 
| D007662 | Ketosis | C00000990 | 
| D015431 | Weight Loss | C00000990 |