Species

KNApSAcK Entry

Organism name Symplocos lancifolia
Genus Symplocos
Family Symplocaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Symplocos lancifolia
Linked NCBI taxonomy ID 239704
Linked level species

Family

Family in NCBI taxonomy Symplocaceae
ID 20019

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000990 External link 512 Phloridzin
/ Phloretin 2'-glucoside
CHEMBL45266
CHEMBL245067
CHEMBL1320052
CHEMBL1524370
CHEMBL2096900
D010695
16 / 15 / 14 3 / 7 No. 36 No. 13
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00002631 External link 512 (+)-Lirioresinol B
/ (+)-Syringaresinol
CHEMBL361362
CHEMBL402653
C042192
1 / 0 / 0 No. 38 No. 21
C00007204 External link 512 Isolariciresinol
/ (+)-Isolariciresinol
CHEMBL399512
CHEMBL1760593
C060284
2 / 1 / 1 No. 406
C00002591 External link 512 (-)-Cubebin
/ beta-Cubebin
/ (-)-beta-Cubebin
/ (8R,8'R,9S)-Cubebin
CHEMBL182001
CHEMBL399831
C433065
2 / 1 / 1 0 / 2 No. 629 No. 21

Human Protein / Gene in interactions

25 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000990 C00002591 C00007204 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002591 C00007204 1 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000990 0 / 0
O00337 Sodium/nucleoside cotransporter 1 Unclassified protein C00000990 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00007190 0 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 0 / 0
Q9HAS3 Solute carrier family 28 member 3 Unclassified protein C00000990 0 / 0
Q99808 Equilibrative nucleoside transporter 1 Nucleoside uniporter C00000990 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00000990 3 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000990 0 / 1
P11387 DNA topoisomerase 1 Isomerase C00002631 0 / 0
P31639 Sodium/glucose cotransporter 2 Glucose C00000990 1 / 1
Q9NY91 Low affinity sodium-glucose cotransporter Unclassified protein C00000990 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 5 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000990 3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000990 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000990 1 / 1
P13866 Sodium/glucose cotransporter 1 Glucose C00000990 1 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00000990 4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 0 / 0
O43868 Sodium/nucleoside cotransporter 2 Unclassified protein C00000990 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000990 0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 0 / 0

3 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00000990
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000990
6523 SLC5A1, D22S675, NAGT, SGLT1 solute carrier family 5 (sodium/glucose cotransporter), member 1 C00000990

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
%606641 Body mass index; bmi P37231
#609338 Carotid intimal medial thickness 1 P37231
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#606824 Glucose/galactose malabsorption; ggm P13866
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#233100 Renal glucosuria; glys1 P31639
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (20)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

9 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D004487 Edema C00002591
D010146 Pain C00002591
D002418 Cattle Diseases C00000990
D003921 Diabetes Mellitus, Experimental C00000990
D006029 Glycosuria C00000990
D006943 Hyperglycemia C00000990
D007003 Hypoglycemia C00000990
D007662 Ketosis C00000990
D015431 Weight Loss C00000990