Organism name | Malus spp. |
---|---|
Genus | Malus |
Family | Rosaceae |
Kingdom | Plantae |
Linked NCBI taxonomy name | Malus |
---|---|
Linked NCBI taxonomy ID | 3749 |
Linked level | genus |
Family in NCBI taxonomy | Rosaceae |
---|---|
ID | 3745 |
Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
---|---|
ID | 33090 |
Plant class | rosids |
---|---|
ID | 71275 |
KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
---|---|---|---|---|---|---|---|---|
C00002378
![]() |
Cyanin
/ Cyanidin 3,5-diglucoside |
No. 1 | No. 15 |
![]() |
||||
C00003558
![]() |
Ursolic acid
|
CHEMBL297810
CHEMBL56048 CHEMBL300594 CHEMBL169 CHEMBL176234 CHEMBL491715 CHEMBL1316667 CHEMBL1555307 CHEMBL1593360 CHEMBL1979720 |
C005466
|
47 / 26 / 33 | 15 / 12 | No. 13 | No. 51 |
![]() |
C00002935
![]() |
Procyanidin B4
/ Catechin-(4alpha->8)-epicatechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
20 / 7 / 8 | No. 16 | No. 19 |
![]() |
||
C00009075
![]() |
Procyanidin B1
/ Epicatechin-(4beta->8)-catechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
C479579
|
20 / 7 / 8 | No. 16 | No. 19 |
![]() |
|
C00009077
![]() |
Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin |
CHEMBL38714
CHEMBL81753 CHEMBL504937 CHEMBL501490 CHEMBL447373 CHEMBL1253314 CHEMBL1590914 |
C479580
|
20 / 7 / 8 | 10 / 0 | No. 16 | No. 19 |
![]() |
C00000990
![]() |
Phloridzin
/ Phloretin 2'-glucoside |
CHEMBL45266
CHEMBL245067 CHEMBL1320052 CHEMBL1524370 CHEMBL2096900 |
D010695
|
16 / 15 / 14 | 3 / 7 | No. 36 | No. 13 |
![]() |
C00003780
![]() |
Neoxanthin
/ Folioxanthin |
C011947
|
4 / 0 | No. 114 | No. 59 |
![]() |
||
C00003130
![]() |
alpha.-Farnesene
/ trans-alpha-Farnesene / (E,E)-alpha-Farnesene |
C062672
|
No. 404 | No. 38 |
![]() |
|||
C00003767
![]() |
5,6-epoxy-beta-Carotene
/ beta-Carotene 5,6-epoxide |
C073147
|
No. 1206 | No. 59 |
![]() |
accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|
P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000990 C00002935 C00003558 C00009075 C00009077 | 0 / 1 |
P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000990 C00002935 C00003558 C00009075 C00009077 | 0 / 1 |
P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000990 C00002935 C00003558 C00009075 C00009077 | 1 / 1 |
P18433 | Receptor-type tyrosine-protein phosphatase alpha | Receptor tyrosine-protein phosphatase | C00002935 C00003558 C00009075 C00009077 | 0 / 0 |
Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000990 C00002935 C00009075 C00009077 | 3 / 3 |
P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002935 C00003558 C00009075 C00009077 | 0 / 0 |
P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002935 C00003558 C00009075 C00009077 | 1 / 0 |
P17252 | Protein kinase C alpha type | Alpha | C00002935 C00009075 C00009077 | 0 / 0 |
O94806 | Serine/threonine-protein kinase D3 | Pkd | C00002935 C00009075 C00009077 | 0 / 0 |
Q05655 | Protein kinase C delta type | Delta | C00002935 C00009075 C00009077 | 0 / 0 |
Q04759 | Protein kinase C theta type | Delta | C00002935 C00009075 C00009077 | 0 / 1 |
P05129 | Protein kinase C gamma type | Alpha | C00002935 C00009075 C00009077 | 1 / 1 |
P05771 | Protein kinase C beta type | Alpha | C00002935 C00009075 C00009077 | 0 / 0 |
P24723 | Protein kinase C eta type | Eta | C00002935 C00009075 C00009077 | 1 / 0 |
P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002935 C00009075 C00009077 | 0 / 0 |
P23467 | Receptor-type tyrosine-protein phosphatase beta | Receptor tyrosine-protein phosphatase | C00002935 C00009075 C00009077 | 0 / 0 |
P41743 | Protein kinase C iota type | Iota | C00002935 C00009075 C00009077 | 0 / 0 |
Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00002935 C00009075 C00009077 | 0 / 0 |
Q02156 | Protein kinase C epsilon type | Eta | C00002935 C00009075 C00009077 | 0 / 0 |
Q05513 | Protein kinase C zeta type | Iota | C00002935 C00009075 C00009077 | 0 / 0 |
P10828 | Thyroid hormone receptor beta | NR1A2 | C00000990 C00003558 | 3 / 1 |
Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00000990 C00003558 | 0 / 0 |
B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000990 | 0 / 0 |
Q9NY91 | Low affinity sodium-glucose cotransporter | Unclassified protein | C00000990 | 0 / 0 |
P15121 | Aldose reductase | Enzyme | C00003558 | 0 / 0 |
P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003558 | 0 / 0 |
Q04206 | Transcription factor p65 | Transcription Factor | C00003558 | 0 / 0 |
P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003558 | 0 / 0 |
O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003558 | 0 / 0 |
P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00003558 | 2 / 2 |
Q96RI1 | Bile acid receptor | NR1H4 | C00003558 | 0 / 0 |
O15379 | Histone deacetylase 3 | Hydrolase | C00003558 | 0 / 0 |
P28845 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Enzyme | C00003558 | 1 / 1 |
P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00003558 | 0 / 0 |
P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000990 | 2 / 2 |
P56524 | Histone deacetylase 4 | Hydrolase | C00003558 | 1 / 1 |
Q99808 | Equilibrative nucleoside transporter 1 | Nucleoside uniporter | C00000990 | 0 / 0 |
P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003558 | 0 / 0 |
P30305 | M-phase inducer phosphatase 2 | Ser_Thr_Tyr | C00003558 | 0 / 0 |
P08047 | Transcription factor Sp1 | Unclassified protein | C00003558 | 0 / 0 |
P02545 | Prelamin-A/C | Unclassified protein | C00003558 | 11 / 10 |
O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003558 | 0 / 0 |
P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00003558 | 0 / 0 |
P10636 | Microtubule-associated protein tau | Unclassified protein | C00000990 | 4 / 3 |
Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003558 | 0 / 0 |
P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00003558 | 0 / 1 |
Q9UBN7 | Histone deacetylase 6 | Hydrolase | C00003558 | 0 / 0 |
P29350 | Tyrosine-protein phosphatase non-receptor type 6 | Tyr | C00003558 | 0 / 0 |
P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003558 | 1 / 1 |
P23469 | Receptor-type tyrosine-protein phosphatase epsilon | Receptor tyrosine-protein phosphatase | C00003558 | 0 / 0 |
O43868 | Sodium/nucleoside cotransporter 2 | Unclassified protein | C00000990 | 0 / 0 |
Q9UQL6 | Histone deacetylase 5 | Hydrolase | C00003558 | 0 / 0 |
P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00003558 | 0 / 0 |
O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00003558 | 1 / 0 |
O00255 | Menin | Unclassified protein | C00003558 | 2 / 5 |
Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00003558 | 1 / 2 |
Q13951 | Core-binding factor subunit beta | Unclassified protein | C00003558 | 0 / 1 |
Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00003558 | 1 / 4 |
Q9HAS3 | Solute carrier family 28 member 3 | Unclassified protein | C00000990 | 0 / 0 |
Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003558 | 0 / 0 |
P24666 | Low molecular weight phosphotyrosine protein phosphatase | Tyr | C00003558 | 0 / 0 |
Q13547 | Histone deacetylase 1 | Hydrolase | C00003558 | 0 / 0 |
P06746 | DNA polymerase beta | Enzyme | C00003558 | 0 / 0 |
P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003558 | 0 / 3 |
O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00003558 | 0 / 0 |
O00337 | Sodium/nucleoside cotransporter 1 | Unclassified protein | C00000990 | 0 / 0 |
P31639 | Sodium/glucose cotransporter 2 | Glucose | C00000990 | 1 / 1 |
P13866 | Sodium/glucose cotransporter 1 | Glucose | C00000990 | 1 / 1 |
P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003558 | 0 / 0 |
O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00003558 | 0 / 0 |
gene | gene name | gene description | KNApSAcK metabolite in interactions |
---|---|---|---|
836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003558
C00003780
C00009077
|
7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00003558
C00009077
|
581 | BAX, BCL2L4 | BCL2-associated X protein |
C00003558
C00009077
|
842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00003780
C00009077
|
9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00003558
C00003780
|
841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00003558
C00003780
|
54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00003558
C00009077
|
7040 | TGFB1, CED, DPD1, LAP, TGFB, TGFbeta | transforming growth factor, beta 1 |
C00003558
|
3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00003558
|
4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00003558
|
4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00003558
|
142 | PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 | poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) |
C00003558
|
1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00003558
|
7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00003558
|
596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00003558
|
578 | BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 | BCL2-antagonist/killer 1 |
C00003558
|
207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00009077
|
2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00009077
|
5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00009077
|
5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00009077
|
4240 | MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 | milk fat globule-EGF factor 8 protein |
C00009077
|
213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00000990
|
4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00000990
|
6523 | SLC5A1, D22S675, NAGT, SGLT1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
C00000990
|
OMIM | preferred title | UniProt |
---|---|---|
#300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
#218030 | Apparent mineralocorticoid excess; ame |
P80365
|
#613546 | Aromatase deficiency |
P11511
|
#139300 | Aromatase excess syndrome; aexs |
P11511
|
#600430 | Brachydactyly-mental retardation syndrome; bdmr |
P56524
|
#115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
#212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
#605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
#604931 | Cortisone reductase deficiency 1; cortrd1 |
P28845
|
#119900 | Digital clubbing, isolated congenital |
P15428
|
#609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
#608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
#181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
#600274 | Frontotemporal dementia; ftd |
P10636
|
#137800 | Glioma susceptibility 1; glm1 |
O75874
|
#606824 | Glucose/galactose malabsorption; ggm |
P13866
|
#605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
#610140 | Heart-hand syndrome, slovenian type |
P02545
|
#176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
#145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
#259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
#151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
#248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
#300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
#300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
#131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
#613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
#159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
#260540 | Parkinson-dementia syndrome |
P10636
|
#172700 | Pick disease of brain |
P10636
|
#601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
#233100 | Renal glucosuria; glys1 |
P31639
|
#275210 | Restrictive dermopathy, lethal |
P02545
|
#605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
#601367 | Stroke, ischemic |
P24723
|
#601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
#188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
#274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
#145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG | name | UniProt |
---|---|---|
H00033 | Adrenal carcinoma |
O00255
(related)
|
H00034 | Carcinoid |
O00255
(related)
|
H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
H00246 | Primary hyperparathyroidism |
O00255
(related)
|
H01102 | Pituitary adenomas |
O00255
(related)
|
H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
H00663 | Restrictive dermopathy |
P02545
(related)
|
H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
H00036 | Osteosarcoma |
P08684
(marker)
|
H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
H00794 | Aromatase excess syndrome |
P11511
(related)
|
H01205 | Coumarin resistance |
P11712
(related)
|
H01261 | Congenital glucose-galactose malabsorption (GGM) |
P13866
(related)
|
H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
H00408 | Type I diabetes mellitus |
P17706
(related)
Q04759 (related) |
H01111 | Cortisone reductase deficiency (CRD) |
P28845
(related)
|
H01126 | Familial renal glucosuria (FRG) |
P31639
(related)
|
H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
H00017 | Esophageal cancer |
P35354
(related)
|
H00025 | Penile cancer |
P35354
(related)
|
H00046 | Cholangiocarcinoma |
P35354
(related)
|
H00561 | Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome |
P56524
(related)
|
H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
MESH or OMIM | name |
KNApSAcK
metabolite |
---|---|---|
D003921 | Diabetes Mellitus, Experimental |
C00003558
C00000990 |
D006943 | Hyperglycemia |
C00003558
C00000990 |
D008103 | Liver Cirrhosis |
C00003558
|
D001284 | Atrophy |
C00003558
|
D006528 | Carcinoma, Hepatocellular |
C00003558
|
D006949 | Hyperlipidemias |
C00003558
|
D006965 | Hyperplasia |
C00003558
|
D007249 | Inflammation |
C00003558
|
D002471 | Cell Transformation, Neoplastic |
C00003558
|
D017202 | Myocardial Ischemia |
C00003558
|
D009369 | Neoplasms |
C00003558
|
D012878 | Skin Neoplasms |
C00003558
|
D002418 | Cattle Diseases |
C00000990
|
D006029 | Glycosuria |
C00000990
|
D007003 | Hypoglycemia |
C00000990
|
D007662 | Ketosis |
C00000990
|
D015431 | Weight Loss |
C00000990
|