Species

KNApSAcK Entry

Organism name Malus spp.
Genus Malus
Family Rosaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Malus
Linked NCBI taxonomy ID 3749
Linked level genus

Family

Family in NCBI taxonomy Rosaceae
ID 3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (9)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00002378 External link 512 Cyanin
/ Cyanidin 3,5-diglucoside
No. 1 No. 15
C00003558 External link 512 Ursolic acid
CHEMBL297810
CHEMBL56048
CHEMBL300594
CHEMBL169
CHEMBL176234
CHEMBL491715
CHEMBL1316667
CHEMBL1555307
CHEMBL1593360
CHEMBL1979720
C005466
47 / 26 / 33 15 / 12 No. 13 No. 51
C00002935 External link 512 Procyanidin B4
/ Catechin-(4alpha->8)-epicatechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
20 / 7 / 8 No. 16 No. 19
C00009075 External link 512 Procyanidin B1
/ Epicatechin-(4beta->8)-catechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479579
20 / 7 / 8 No. 16 No. 19
C00009077 External link 512 Procyanidin B2
/ Epicathechin-(4beta->8)-epicathechin
CHEMBL38714
CHEMBL81753
CHEMBL504937
CHEMBL501490
CHEMBL447373
CHEMBL1253314
CHEMBL1590914
C479580
20 / 7 / 8 10 / 0 No. 16 No. 19
C00000990 External link 512 Phloridzin
/ Phloretin 2'-glucoside
CHEMBL45266
CHEMBL245067
CHEMBL1320052
CHEMBL1524370
CHEMBL2096900
D010695
16 / 15 / 14 3 / 7 No. 36 No. 13
C00003780 External link 512 Neoxanthin
/ Folioxanthin
C011947
4 / 0 No. 114 No. 59
C00003130 External link 512 alpha.-Farnesene
/ trans-alpha-Farnesene
/ (E,E)-alpha-Farnesene
C062672
No. 404 No. 38
C00003767 External link 512 5,6-epoxy-beta-Carotene
/ beta-Carotene 5,6-epoxide
C073147
No. 1206 No. 59

Human Protein / Gene in interactions

71 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000990 C00002935 C00003558 C00009075 C00009077 0 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000990 C00002935 C00003558 C00009075 C00009077 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000990 C00002935 C00003558 C00009075 C00009077 1 / 1
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00002935 C00003558 C00009075 C00009077 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000990 C00002935 C00009075 C00009077 3 / 3
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002935 C00003558 C00009075 C00009077 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002935 C00003558 C00009075 C00009077 1 / 0
P17252 Protein kinase C alpha type Alpha C00002935 C00009075 C00009077 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00002935 C00009075 C00009077 0 / 0
Q05655 Protein kinase C delta type Delta C00002935 C00009075 C00009077 0 / 0
Q04759 Protein kinase C theta type Delta C00002935 C00009075 C00009077 0 / 1
P05129 Protein kinase C gamma type Alpha C00002935 C00009075 C00009077 1 / 1
P05771 Protein kinase C beta type Alpha C00002935 C00009075 C00009077 0 / 0
P24723 Protein kinase C eta type Eta C00002935 C00009075 C00009077 1 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002935 C00009075 C00009077 0 / 0
P23467 Receptor-type tyrosine-protein phosphatase beta Receptor tyrosine-protein phosphatase C00002935 C00009075 C00009077 0 / 0
P41743 Protein kinase C iota type Iota C00002935 C00009075 C00009077 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00002935 C00009075 C00009077 0 / 0
Q02156 Protein kinase C epsilon type Eta C00002935 C00009075 C00009077 0 / 0
Q05513 Protein kinase C zeta type Iota C00002935 C00009075 C00009077 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00000990 C00003558 3 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme C00000990 C00003558 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000990 0 / 0
Q9NY91 Low affinity sodium-glucose cotransporter Unclassified protein C00000990 0 / 0
P15121 Aldose reductase Enzyme C00003558 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003558 0 / 0
Q04206 Transcription factor p65 Transcription Factor C00003558 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00003558 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003558 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00003558 2 / 2
Q96RI1 Bile acid receptor NR1H4 C00003558 0 / 0
O15379 Histone deacetylase 3 Hydrolase C00003558 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00003558 1 / 1
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00003558 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00003558 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000990 2 / 2
P56524 Histone deacetylase 4 Hydrolase C00003558 1 / 1
Q99808 Equilibrative nucleoside transporter 1 Nucleoside uniporter C00000990 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00003558 0 / 0
P30305 M-phase inducer phosphatase 2 Ser_Thr_Tyr C00003558 0 / 0
P08047 Transcription factor Sp1 Unclassified protein C00003558 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003558 11 / 10
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003558 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00003558 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000990 4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003558 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00003558 0 / 1
Q9UBN7 Histone deacetylase 6 Hydrolase C00003558 0 / 0
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00003558 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003558 1 / 1
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00003558 0 / 0
O43868 Sodium/nucleoside cotransporter 2 Unclassified protein C00000990 0 / 0
Q9UQL6 Histone deacetylase 5 Hydrolase C00003558 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00003558 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003558 1 / 0
O00255 Menin Unclassified protein C00003558 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00003558 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00003558 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00003558 1 / 4
Q9HAS3 Solute carrier family 28 member 3 Unclassified protein C00000990 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003558 0 / 0
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00003558 0 / 0
Q13547 Histone deacetylase 1 Hydrolase C00003558 0 / 0
P06746 DNA polymerase beta Enzyme C00003558 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00003558 0 / 3
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00003558 0 / 0
O00337 Sodium/nucleoside cotransporter 1 Unclassified protein C00000990 0 / 0
P31639 Sodium/glucose cotransporter 2 Glucose C00000990 1 / 1
P13866 Sodium/glucose cotransporter 1 Glucose C00000990 1 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003558 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00003558 0 / 0

24 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00003558 C00003780 C00009077
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00003558 C00009077
581 BAX, BCL2L4 BCL2-associated X protein C00003558 C00009077
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00003780 C00009077
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00003558 C00003780
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00003558 C00003780
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00003558 C00009077
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00003558
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00003558
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00003558
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00003558
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00003558
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003558
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00003558
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00003558
578 BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 BCL2-antagonist/killer 1 C00003558
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00009077
2932 GSK3B glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) C00009077
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00009077
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00009077
4240 MFGE8, BA46, EDIL1, HMFG, HsT19888, MFG-E8, MFGM, OAcGD3S, SED1, SPAG10, hP47 milk fat globule-EGF factor 8 protein C00009077
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00000990
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000990
6523 SLC5A1, D22S675, NAGT, SGLT1 solute carrier family 5 (sodium/glucose cotransporter), member 1 C00000990

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (39)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600430 Brachydactyly-mental retardation syndrome; bdmr P56524
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#606824 Glucose/galactose malabsorption; ggm P13866
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#233100 Renal glucosuria; glys1 P31639
#275210 Restrictive dermopathy, lethal P02545
#605361 Spinocerebellar ataxia 14; sca14 P05129
#601367 Stroke, ischemic P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (44)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H01261 Congenital glucose-galactose malabsorption (GGM) P13866 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00408 Type I diabetes mellitus P17706 (related)
Q04759 (related)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01126 Familial renal glucosuria (FRG) P31639 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00561 Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome P56524 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

17 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003921 Diabetes Mellitus, Experimental C00003558
C00000990
D006943 Hyperglycemia C00003558
C00000990
D008103 Liver Cirrhosis C00003558
D001284 Atrophy C00003558
D006528 Carcinoma, Hepatocellular C00003558
D006949 Hyperlipidemias C00003558
D006965 Hyperplasia C00003558
D007249 Inflammation C00003558
D002471 Cell Transformation, Neoplastic C00003558
D017202 Myocardial Ischemia C00003558
D009369 Neoplasms C00003558
D012878 Skin Neoplasms C00003558
D002418 Cattle Diseases C00000990
D006029 Glycosuria C00000990
D007003 Hypoglycemia C00000990
D007662 Ketosis C00000990
D015431 Weight Loss C00000990