Ricinus communis
Species
KNApSAcK Entry
| Organism name | Ricinus communis |
|---|---|
| Genus | Ricinus |
| Family | Euphorbiaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Ricinus communis |
|---|---|
| Linked NCBI taxonomy ID | 3988 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Euphorbiaceae |
|---|---|
| ID | 3977 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (42)
| Species | Activity |
|---|---|
| Ricinus communis L. | Analgesic |
| Ricinus communis L. | Anti-HIV |
| Ricinus communis L. | Antiabsorptive |
| Ricinus communis L. | Antibacterial |
| Ricinus communis L. | Anticholestatic |
| Ricinus communis L. | Antidiabetic |
| Ricinus communis L. | Antidote |
| Ricinus communis L. | Antilactagogue |
| Ricinus communis L. | Antileukemic |
| Ricinus communis L. | Antiseptic |
| Ricinus communis L. | Antitumor |
| Ricinus communis L. | Antitussive |
| Ricinus communis L. | Antiviral |
| Ricinus communis L. | Aperient |
| Ricinus communis L. | Candidicide |
| Ricinus communis L. | Contraceptive |
| Ricinus communis L. | Cyanogenic |
| Ricinus communis L. | Diaphoretic |
| Ricinus communis L. | Discutient |
| Ricinus communis L. | Diuretic |
| Ricinus communis L. | Emetic |
| Ricinus communis L. | Emmenagogue |
| Ricinus communis L. | Emollient |
| Ricinus communis L. | Expectorant |
| Ricinus communis L. | Fungicide |
| Ricinus communis L. | Hepatoprotective |
| Ricinus communis L. | Hypotensive |
| Ricinus communis L. | Immunostimulant |
| Ricinus communis L. | Insecticide |
| Ricinus communis L. | Lactagogue |
| Ricinus communis L. | Larvicide |
| Ricinus communis L. | Laxative |
| Ricinus communis L. | Lymphocytogenic |
| Ricinus communis L. | Parturient |
| Ricinus communis L. | Peristaltic |
| Ricinus communis L. | Piscicide |
| Ricinus communis L. | Poison |
| Ricinus communis L. | Pyrogenic |
| Ricinus communis L. | Secretagogue |
| Ricinus communis L. | Secretomotor |
| Ricinus communis L. | Spermicide |
| Ricinus communis L. | Tonic |
Metabolite list (15)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00013786
|
Ricinitin
/ Kaempferol 3-(6''-acetylglucosyl)-(1->3)-galactoside / 3-[[3-O-(6-O-Acetyl-beta-D-glucopyranosyl)-beta-D-galactopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one |
No. 1 | No. 15 |
|
||||
|
C00005134
|
Kaempferol 3-xyloside
|
CHEMBL518420
CHEMBL477730 |
No. 2 | No. 15 |
|
|||
|
C00005370
|
Reynoutrin
|
CHEMBL183031
CHEMBL185461 CHEMBL488198 CHEMBL464507 CHEMBL520637 |
No. 2 | No. 15 |
|
|||
|
C00014318
|
Naringenin 7-(2-p-Coumaroylglucoside)
/ 5,7,4'-Trihydroxyflavanone 7-(2-p-Coumaroylglucoside) |
No. 540 |
|
|||||
|
C00002915
|
Corilagin
|
CHEMBL449392
CHEMBL1425538 |
C049096
|
44 / 45 / 33 | No. 818 | No. 81 |
|
|
|
C00001214
|
9,10-Dihydroxystearic acid
|
C074110
|
No. 1037 |
|
||||
|
C00000100
|
IAA
/ Indole-3-acetic acid |
CHEMBL82411
|
C030737
|
3 / 0 / 0 | 2 / 1 | No. 1432 | No. 4 |
|
|
C00001202
|
Sebacic acid
|
CHEMBL1232164
|
C011107
|
1 / 0 | No. 1853 |
|
||
|
C00001199
|
Pimelic acid
|
No. 1853 |
|
|||||
|
C00001204
|
Suberic acid
|
CHEMBL1162491
|
C005738
|
1 / 3 / 1 | No. 1853 |
|
||
|
C00000864
|
1S,3R-Casbene
|
No. 2435 | No. 42 |
|
||||
|
C00000880
|
ent-CPP
/ ent-Copalyl diphosphate |
No. 4186 | No. 46 |
|
||||
|
C00000101
|
IAA methyl ester
/ Methyl indole-3-acetate |
No. 4225 |
|
|||||
|
C00002069
|
Ricinine
|
CHEMBL1329957
|
C019550
|
10 / 17 / 16 | No. 7534 | No. 1 |
|
|
|
C00001186
|
Glyoxylic acid
|
CHEMBL1162545
|
C031150
|
1 / 0 / 0 | 0 / 1 | No. 7855 |
|
Human Protein / Gene in interactions
56 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P02545 | Prelamin-A/C | Unclassified protein | C00002069 C00002915 | 11 / 10 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002069 C00002915 | 4 / 3 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002069 C00002915 | 0 / 0 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002915 | 4 / 2 |
| P06746 | DNA polymerase beta | Enzyme | C00002915 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002915 | 1 / 1 |
| Q16773 | Kynurenine--oxoglutarate transaminase 1 | Enzyme | C00000100 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002915 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002915 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002915 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002069 | 1 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001204 | 3 / 1 |
| P02768 | Serum albumin | Secreted protein | C00000100 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002069 | 0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | C00002915 | 1 / 2 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002915 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002915 | 2 / 2 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002915 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002915 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002915 | 2 / 0 |
| O75496 | Geminin | Unclassified protein | C00002069 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002915 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002915 | 1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002069 | 0 / 0 |
| P98073 | Enteropeptidase | Enzyme | C00002915 | 1 / 1 |
| Q9HBH1 | Peptide deformylase, mitochondrial | Enzyme | C00000100 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002069 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002915 | 2 / 2 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002915 | 2 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002069 | 1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002069 | 0 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002915 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002915 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002915 | 0 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00002915 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002915 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002915 | 0 / 0 |
| P55072 | Transitional endoplasmic reticulum ATPase | Unclassified protein | C00002915 | 2 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002915 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002915 | 1 / 4 |
| Q05513 | Protein kinase C zeta type | Iota | C00002915 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00002915 | 0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | C00002915 | 0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00002915 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00002915 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00002915 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00002915 | 1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | C00002915 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00002915 | 1 / 0 |
| P41743 | Protein kinase C iota type | Iota | C00002915 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00002915 | 0 / 0 |
| O15427 | Monocarboxylate transporter 4 | Unclassified protein | C00001186 | 0 / 0 |
| P19429 | Troponin I, cardiac muscle | Unclassified protein | C00002915 | 4 / 4 |
| P45379 | Troponin T, cardiac muscle | Unclassified protein | C00002915 | 3 / 5 |
| P63316 | Troponin C, slow skeletal and cardiac muscles | Other cytosolic protein | C00002915 | 2 / 2 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002915 | 2 / 1 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 128 | ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR | alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) |
C00001202
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000100
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00000100
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (50)
| OMIM | preferred title | UniProt |
|---|---|---|
| #613954 | Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 |
P55072
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #601494 | Cardiomyopathy, dilated, 1d; cmd1d |
P45379
|
| #613286 | Cardiomyopathy, dilated, 1ff; cmd1ff |
P19429
|
| #611879 | Cardiomyopathy, dilated, 1z; cmd1z |
P63316
|
| #611880 | Cardiomyopathy, dilated, 2a; cmd2a |
P19429
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #613243 | Cardiomyopathy, familial hypertrophic, 13; cmh13 |
P63316
|
| #115195 | Cardiomyopathy, familial hypertrophic, 2; cmh2 |
P45379
|
| #613690 | Cardiomyopathy, familial hypertrophic, 7; cmh7 |
P19429
|
| #115210 | Cardiomyopathy, familial restrictive, 1; rcm1 |
P19429
|
| #612422 | Cardiomyopathy, familial restrictive, 3; rcm3 |
P45379
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #226200 | Enterokinase deficiency |
P98073
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #167320 | Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 |
P55072
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P12821
P24723 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277700 | Werner syndrome; wrn |
Q14191
|
KEGG DISEASE (37)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
P19429 (related) P45379 (related) P63316 (related) |
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
P45379 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
P55072 (related) |
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00292 | Hypertrophic cardiomyopathy (HCM) |
P19429
(related)
P45379 (related) P63316 (related) |
| H01219 | Restrictive cardiomyopathy (RCM) |
P19429
(related)
P45379 (related) |
| H00295 | Viral myocarditis |
P19429
(marker)
P45379 (marker) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00988 | Enterokinase deficiency |
P98073
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|