PCIDB

KCF-S cluster No. 1853 (6 metabolites)

Plant Species

Cumulative plant class count

class name count
rosids 4
eudicotyledons 2
asterids 1

Cumulative family count

class name count
Euphorbiaceae 3
Amaranthaceae 2
Fabaceae 1
Lamiaceae 1

KEGG BRITE br08003 External link 512

Categories (0)

br08003 Category # of metabolite

metabolites link (0)

br08003 Category KEGG ID KNApSAcK ID

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		figure
C00001178 External link 512 Adipic acid
CHEMBL1157
C029900
4 / 14 / 11 1 / 0
C00001184 External link 512 Glutaric acid
CHEMBL1162495
C035736
3 / 0 / 0 2 / 0
C00001199 External link 512 Pimelic acid
C00001202 External link 512 Sebacic acid
CHEMBL1232164
C011107
1 / 0
C00001204 External link 512 Suberic acid
CHEMBL1162491
C005738
1 / 3 / 1
C00045634 External link 512 Anchoic acid
CHEMBL1238
C010038
17 / 23 / 19 4 / 11

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein C00001178 C00045634 11 / 10
P10828 Thyroid hormone receptor beta NR1A2 C00001178 C00001204 3 / 1
O75496 Geminin Unclassified protein C00045634 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001178 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00045634 1 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00045634 3 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00045634 0 / 0
P40925 Malate dehydrogenase, cytoplasmic Enzyme C00045634 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00045634 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00045634 1 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001178 0 / 0
Q99895 Chymotrypsin-C S1A C00045634 0 / 2
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00001184 0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00001184 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00045634 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00045634 5 / 2
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00045634 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00045634 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00045634 0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00045634 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00045634 0 / 0
Q9NSA0 Solute carrier family 22 member 11 Transporter C00001184 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00045634 1 / 1

7 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
9356 SLC22A6, HOAT1, OAT1, PAHT, ROAT1 solute carrier family 22 (organic anion transporter), member 6 C00001178 C00001184
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00045634
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00045634
5328 PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA plasminogen activator, urokinase (EC:3.4.21.73) C00045634
128 ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) C00001202
5327 PLAT, T-PA, TPA plasminogen activator, tissue (EC:3.4.21.68) C00045634
55867 SLC22A11, OAT4, hOAT4 solute carrier family 22 (organic anion/urate transporter), member 11 C00001184

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (26)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#275210 Restrictive dermopathy, lethal P02545
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828

KEGG DISEASE (20)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00932 Tropical calcific pancreatitis Q99895 (related)
H00933 Hereditary pancreatitis Q99895 (related)

Diseases related to CTD interactions

11 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000152 Acne Vulgaris C00045634
D050197 Atherosclerosis C00045634
D003876 Dermatitis, Atopic C00045634
D019557 Dermatitis, Perioral C00045634
D018327 Hutchinson's Melanotic Freckle C00045634
D017495 Hyperpigmentation C00045634
D007249 Inflammation C00045634
D008548 Melanosis C00045634
D011565 Psoriasis C00045634
D012393 Rosacea C00045634
D012871 Skin Diseases C00045634