KNApSAcK Metabolite C00045634
Metabolite
KNApSAcK Entry
| id | C00045634 |
|---|---|
| Name | Anchoic acid |
| CAS RN | 123-99-9 |
| Standard InChI | InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13) |
| Standard InChI (Main Layer) | InChI=1S/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1853 |
Link
ChEMBL
| By standard InChI | CHEMBL1238 |
|---|---|
| By standard InChI Main Layer | CHEMBL1238 |
KEGG
| By LinkDB | C08261 |
|---|
CTD
| By CAS RN | C010038 |
|---|
Species
Summary
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Schnabelia tetradonta | 167918 | Lamiaceae | asterids | Viridiplantae |
Human Protein / Gene in interaction
17 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1238 |
CHEMBL1741321
(1)
|
1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL1238 |
CHEMBL1738312
(1)
|
0 / 0 |
| Q99895 | Chymotrypsin-C | S1A | CHEMBL1238 |
CHEMBL660318
(1)
|
0 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL1238 |
CHEMBL1614544
(2)
|
11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL1238 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P40925 | Malate dehydrogenase, cytoplasmic | Enzyme | CHEMBL1238 |
CHEMBL709633
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1238 |
CHEMBL1741325
(1)
|
0 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | CHEMBL1238 |
CHEMBL1614166
(1)
CHEMBL1738096
(1)
CHEMBL1738622 (1) |
1 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL1238 |
CHEMBL2114780
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1238 |
CHEMBL1741322
(1)
|
0 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | CHEMBL1238 |
CHEMBL1614171
(1)
|
5 / 2 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | CHEMBL1238 |
CHEMBL1614274
(1)
CHEMBL1613823
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1238 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1238 |
CHEMBL1741324
(1)
|
0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | CHEMBL1238 |
CHEMBL1614211
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL1238 |
CHEMBL1738442
(1)
|
0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | CHEMBL1238 |
CHEMBL2354287
(1)
|
1 / 1 |
CTD interaction (8)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C010038 | 5327 |
PLAT
T-PA TPA |
plasminogen activator, tissue (EC:3.4.21.68) | azelaic acid results in decreased expression of and results in decreased secretion of PLAT protein |
decreases expression
/ decreases secretion |
protein |
8635147
|
| C010038 | 5327 |
PLAT
T-PA TPA |
plasminogen activator, tissue (EC:3.4.21.68) | azelaic acid results in decreased expression of PLAT mRNA |
decreases expression
|
mRNA |
8635147
|
| C010038 | 5328 |
PLAU
ATF BDPLT5 QPD UPA URK u-PA |
plasminogen activator, urokinase (EC:3.4.21.73) | azelaic acid results in decreased expression of and results in decreased secretion of PLAU protein |
decreases expression
/ decreases secretion |
protein |
8635147
|
| C010038 | 5328 |
PLAU
ATF BDPLT5 QPD UPA URK u-PA |
plasminogen activator, urokinase (EC:3.4.21.73) | azelaic acid results in decreased expression of PLAU mRNA |
decreases expression
|
mRNA |
8635147
|
| C010038 | 5468 |
PPARG
CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma |
peroxisome proliferator-activated receptor gamma | azelaic acid results in increased activity of PPARG protein |
increases activity
|
protein |
20545756
|
| C010038 | 5468 |
PPARG
CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma |
peroxisome proliferator-activated receptor gamma | azelaic acid results in increased expression of PPARG mRNA |
increases expression
|
mRNA |
20545756
|
| C010038 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | azelaic acid results in increased expression of and results in increased secretion of SERPINE1 protein |
increases expression
/ increases secretion |
protein |
8635147
|
| C010038 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | azelaic acid results in increased expression of SERPINE1 mRNA |
increases expression
|
mRNA |
8635147
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (23)
| OMIM | preferred title | UniProt |
|---|---|---|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (19)
| KEGG | disease name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00932 | Tropical calcific pancreatitis |
Q99895
(related)
|
| H00933 | Hereditary pancreatitis |
Q99895
(related)
|
Diseases related to CTD interactions
11 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000152 | C010038 | Acne Vulgaris |
therapeutic
|
17456913
18246693 20394495 20482689 20545756 21612319 21637899 22111946 |
|
| D050197 | C010038 | Atherosclerosis |
therapeutic
|
19880116
|
|
| D003876 | C010038 | Dermatitis, Atopic |
therapeutic
|
19804495
|
|
| D019557 | C010038 | Dermatitis, Perioral |
therapeutic
|
19804495
|
|
| D018327 | C010038 | Hutchinson's Melanotic Freckle |
therapeutic
|
8635147
|
|
| D017495 | C010038 | Hyperpigmentation |
therapeutic
|
20804622
21637899 |
|
| D007249 | C010038 | Inflammation |
therapeutic
|
18803456
20545756 |
|
| D008548 | C010038 | Melanosis |
therapeutic
|
22151936
|
|
| D011565 | C010038 | Psoriasis |
therapeutic
|
20684146
|
|
| D012393 | C010038 | Rosacea |
therapeutic
|
17472690
17500380 18561584 18803456 19363903 19588640 20545756 20645521 20967185 21916272 22111946 |
|
| D012871 | C010038 | Skin Diseases |
therapeutic
|
20025951
|