Terminalia chebula
Species
KNApSAcK Entry
| Organism name | Terminalia chebula |
|---|---|
| Genus | Terminalia |
| Family | Combretaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Terminalia chebula |
|---|---|
| Linked NCBI taxonomy ID | 155022 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Combretaceae |
|---|---|
| ID | 3954 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (21)
| Species | Activity |
|---|---|
| Terminalia chebula Retz. | Alterative |
| Terminalia chebula Retz. | Anthelminthic |
| Terminalia chebula Retz. | Antibacterial |
| Terminalia chebula Retz. | Antiherpetic |
| Terminalia chebula Retz. | Antiseptic |
| Terminalia chebula Retz. | Antispasmodic |
| Terminalia chebula Retz. | Antitumor |
| Terminalia chebula Retz. | Antiviral |
| Terminalia chebula Retz. | Astringent |
| Terminalia chebula Retz. | ATPase-Inhibitor |
| Terminalia chebula Retz. | Cardiotonic |
| Terminalia chebula Retz. | Carminative |
| Terminalia chebula Retz. | Cerebrotonic |
| Terminalia chebula Retz. | Dentifrice |
| Terminalia chebula Retz. | Digestive |
| Terminalia chebula Retz. | Diuretic |
| Terminalia chebula Retz. | Expectorant |
| Terminalia chebula Retz. | Hypocholesterolemic |
| Terminalia chebula Retz. | Laxative |
| Terminalia chebula Retz. | Stomachic |
| Terminalia chebula Retz. | Tonic |
Metabolite list (4)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002911
|
Chebulagic acid
|
CHEMBL525240
CHEMBL1970427 |
C076178
|
12 / 2 / 2 | No. 226 | No. 81 |
|
|
|
C00002912
|
Chebulinic acid
|
CHEMBL501154
CHEMBL1159459 CHEMBL1391063 |
C103481
|
29 / 15 / 14 | 6 / 0 | No. 226 | No. 81 |
|
|
C00002933
|
Pentagalloyl-beta-D-glucose
/ 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose / (+)-1,2,3,4,6-Penta-O-galloyl-beta-D-glucose |
CHEMBL127911
CHEMBL262173 CHEMBL206710 CHEMBL207164 CHEMBL382408 CHEMBL377052 CHEMBL425946 CHEMBL383306 CHEMBL207014 CHEMBL1224764 CHEMBL1500249 |
C013185
|
46 / 53 / 44 | 5 / 0 | No. 302 | No. 81 |
|
|
C00002915
|
Corilagin
|
CHEMBL449392
CHEMBL1425538 |
C049096
|
44 / 45 / 33 | No. 818 | No. 81 |
|
Human Protein / Gene in interactions
65 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q02156 | Protein kinase C epsilon type | Eta | C00002911 C00002912 C00002915 C00002933 | 0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | C00002911 C00002912 C00002915 C00002933 | 0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | C00002911 C00002912 C00002915 C00002933 | 0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | C00002911 C00002912 C00002915 C00002933 | 0 / 1 |
| P41743 | Protein kinase C iota type | Iota | C00002911 C00002912 C00002915 C00002933 | 0 / 0 |
| P24723 | Protein kinase C eta type | Eta | C00002911 C00002912 C00002915 C00002933 | 1 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | C00002911 C00002912 C00002915 C00002933 | 0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00002911 C00002912 C00002915 C00002933 | 0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | C00002911 C00002912 C00002915 C00002933 | 0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | C00002911 C00002912 C00002915 C00002933 | 1 / 1 |
| P17252 | Protein kinase C alpha type | Alpha | C00002911 C00002912 C00002915 C00002933 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002912 C00002915 C00002933 | 1 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002912 C00002915 C00002933 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002912 C00002915 C00002933 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002912 C00002915 C00002933 | 4 / 3 |
| P06746 | DNA polymerase beta | Enzyme | C00002912 C00002915 C00002933 | 0 / 0 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002912 C00002915 C00002933 | 1 / 2 |
| P54132 | Bloom syndrome protein | Enzyme | C00002912 C00002915 C00002933 | 1 / 2 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002912 C00002915 C00002933 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002912 C00002915 C00002933 | 0 / 1 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00002912 C00002915 C00002933 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002912 C00002915 C00002933 | 1 / 4 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002912 C00002933 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002911 C00002915 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002912 C00002933 | 1 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002915 C00002933 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002912 C00002933 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002915 C00002933 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002915 C00002933 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002912 C00002933 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002912 C00002933 | 3 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002915 C00002933 | 11 / 10 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002915 C00002933 | 2 / 2 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00002933 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00002933 | 0 / 0 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002915 | 4 / 2 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002915 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002915 | 0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002933 | 2 / 0 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00002933 | 5 / 4 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002915 | 0 / 0 |
| P17706 | Tyrosine-protein phosphatase non-receptor type 2 | Tyr | C00002933 | 0 / 1 |
| P98073 | Enteropeptidase | Enzyme | C00002915 | 1 / 1 |
| P00742 | Coagulation factor X | S1A | C00002933 | 1 / 0 |
| O75496 | Geminin | Unclassified protein | C00002933 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002915 | 2 / 0 |
| P55072 | Transitional endoplasmic reticulum ATPase | Unclassified protein | C00002915 | 2 / 1 |
| O00255 | Menin | Unclassified protein | C00002933 | 2 / 5 |
| P42858 | Huntingtin | Unclassified protein | C00002933 | 1 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002915 | 0 / 0 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002915 | 2 / 2 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002912 | 1 / 0 |
| P10586 | Receptor-type tyrosine-protein phosphatase F | Receptor tyrosine-protein phosphatase | C00002933 | 0 / 0 |
| P03951 | Coagulation factor XI | S1A | C00002933 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002915 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002915 | 0 / 0 |
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00002933 | 4 / 2 |
| P04062 | Glucosylceramidase | Enzyme | C00002933 | 6 / 4 |
| P14618 | Pyruvate kinase PKM | Enzyme | C00002912 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002915 | 2 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002933 | 4 / 1 |
| P19429 | Troponin I, cardiac muscle | Unclassified protein | C00002915 | 4 / 4 |
| P45379 | Troponin T, cardiac muscle | Unclassified protein | C00002915 | 3 / 5 |
| P63316 | Troponin C, slow skeletal and cardiac muscles | Other cytosolic protein | C00002915 | 2 / 2 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002915 | 2 / 1 |
11 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00002933
|
| 3383 | ICAM1, BB2, CD54, P3.58 | intercellular adhesion molecule 1 |
C00002933
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002933
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002933
|
| 7412 | VCAM1, CD106, INCAM-100 | vascular cell adhesion molecule 1 |
C00002933
|
| 43 | ACHE, ACEE, ARACHE, N-ACHE, YT | acetylcholinesterase (EC:3.1.1.7) |
C00002912
|
| 2623 | GATA1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT | GATA binding protein 1 (globin transcription factor 1) |
C00002912
|
| 2624 | GATA2, DCML, MONOMAC, NFE1B | GATA binding protein 2 |
C00002912
|
| 2993 | GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2 | glycophorin A (MNS blood group) |
C00002912
|
| 3145 | HMBS, PBG-D, PBGD, PORC, UPS | hydroxymethylbilane synthase (EC:2.5.1.61) |
C00002912
|
| 4778 | NFE2, NF-E2, p45 | nuclear factor, erythroid 2 |
C00002912
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (75)
| OMIM | preferred title | UniProt |
|---|---|---|
| #613954 | Amyotrophic lateral sclerosis 14, with or without frontotemporal dementia; als14 |
P55072
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #601494 | Cardiomyopathy, dilated, 1d; cmd1d |
P45379
|
| #613286 | Cardiomyopathy, dilated, 1ff; cmd1ff |
P19429
|
| #611879 | Cardiomyopathy, dilated, 1z; cmd1z |
P63316
|
| #611880 | Cardiomyopathy, dilated, 2a; cmd2a |
P19429
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #613243 | Cardiomyopathy, familial hypertrophic, 13; cmh13 |
P63316
|
| #115195 | Cardiomyopathy, familial hypertrophic, 2; cmh2 |
P45379
|
| #613690 | Cardiomyopathy, familial hypertrophic, 7; cmh7 |
P19429
|
| #115210 | Cardiomyopathy, familial restrictive, 1; rcm1 |
P19429
|
| #612422 | Cardiomyopathy, familial restrictive, 3; rcm3 |
P45379
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 Q14191 |
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #246200 | Donohue syndrome |
P06213
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #226200 | Enterokinase deficiency |
P98073
|
| #133239 | Esophageal cancer |
P18054
|
| #227600 | Factor x deficiency |
P00742
|
| #612416 | Factor xi deficiency |
P03951
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #167320 | Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1; ibmpfd1 |
P55072
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
Q06124
|
| #151100 | Leopard syndrome 1 |
Q06124
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #156250 | Metachondromatosis; metcds |
Q06124
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #163950 | Noonan syndrome 1; ns1 |
Q06124
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P12821
P24723 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277700 | Werner syndrome; wrn |
Q14191
|
KEGG DISEASE (52)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
P19429 (related) P45379 (related) P63316 (related) |
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
P45379 (related) |
| H00938 | Factor XI deficiency |
P03951
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
Q9NUW8 (related) |
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
P55072 (related) |
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00408 | Type I diabetes mellitus |
P17706
(related)
Q04759 (related) |
| H00292 | Hypertrophic cardiomyopathy (HCM) |
P19429
(related)
P45379 (related) P63316 (related) |
| H01219 | Restrictive cardiomyopathy (RCM) |
P19429
(related)
P45379 (related) |
| H00295 | Viral myocarditis |
P19429
(marker)
P45379 (marker) |
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00988 | Enterokinase deficiency |
P98073
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q06124
(related)
|
| H01018 | Metachondromatosis |
Q06124
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|