Caesalpinia pulcherrima
Species
KNApSAcK Entry
| Organism name | Caesalpinia pulcherrima |
|---|---|
| Genus | Caesalpinia |
| Family | Fabaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Caesalpinia pulcherrima |
|---|---|
| Linked NCBI taxonomy ID | 53846 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Fabaceae |
|---|---|
| ID | 3803 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | rosids |
|---|---|
| ID | 71275 |
Natural Activity
List (34)
| Species | Activity |
|---|---|
| Caesalpinia pulcherrima (L.) Sw. | Abortifacient |
| Caesalpinia pulcherrima (L.) Sw. | Anthelmintic |
| Caesalpinia pulcherrima (L.) Sw. | Anticancer |
| Caesalpinia pulcherrima (L.) Sw. | Anticancer, breast |
| Caesalpinia pulcherrima (L.) Sw. | Anticancer, lung |
| Caesalpinia pulcherrima (L.) Sw. | Anticancer, oral |
| Caesalpinia pulcherrima (L.) Sw. | AntiHIV |
| Caesalpinia pulcherrima (L.) Sw. | Antiinflammatory |
| Caesalpinia pulcherrima (L.) Sw. | Antiseptic |
| Caesalpinia pulcherrima (L.) Sw. | Antitubercular |
| Caesalpinia pulcherrima (L.) Sw. | Antitussive |
| Caesalpinia pulcherrima (L.) Sw. | Antiviral |
| Caesalpinia pulcherrima (L.) Sw. | Astringent |
| Caesalpinia pulcherrima (L.) Sw. | Bactericide |
| Caesalpinia pulcherrima (L.) Sw. | Bechic |
| Caesalpinia pulcherrima (L.) Sw. | Cathartic |
| Caesalpinia pulcherrima (L.) Sw. | Cytotoxic |
| Caesalpinia pulcherrima (L.) Sw. | Emetic |
| Caesalpinia pulcherrima (L.) Sw. | Emmenagogue |
| Caesalpinia pulcherrima (L.) Sw. | Febrifuge |
| Caesalpinia pulcherrima (L.) Sw. | Fetotoxic |
| Caesalpinia pulcherrima (L.) Sw. | Fungicide |
| Caesalpinia pulcherrima (L.) Sw. | Gram(+)-icide |
| Caesalpinia pulcherrima (L.) Sw. | Hemostat |
| Caesalpinia pulcherrima (L.) Sw. | IL-12-Inhibitor |
| Caesalpinia pulcherrima (L.) Sw. | Laxative |
| Caesalpinia pulcherrima (L.) Sw. | NO-Inhibitor |
| Caesalpinia pulcherrima (L.) Sw. | Piscicide |
| Caesalpinia pulcherrima (L.) Sw. | Purgative |
| Caesalpinia pulcherrima (L.) Sw. | Sudorific |
| Caesalpinia pulcherrima (L.) Sw. | TNF-alpha-Inhibitor |
| Caesalpinia pulcherrima (L.) Sw. | Tonic |
| Caesalpinia pulcherrima (L.) Sw. | Tumor-Promotor |
| Caesalpinia pulcherrima (L.) Sw. | Vulnerary |
Metabolite list (40)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002378
|
Cyanin
/ Cyanidin 3,5-diglucoside |
No. 1 | No. 15 |
|
||||
|
C00005413
|
Rutin
/ Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside |
CHEMBL32579
CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989 |
D012431
|
25 / 18 / 16 | 29 / 8 | No. 1 | No. 15 |
|
|
C00005730
|
Myricitrin
/ Myricetin 3-O-rhamnoside / Myricetin 3-O-alpha-L-rhamnoside / Myricetin 3-O-alpha-L-rhamnopyranoside |
CHEMBL454576
CHEMBL522983 CHEMBL1599224 |
C008577
|
25 / 11 / 11 | No. 2 | No. 15 |
|
|
|
C00005374
|
Quercetin
|
CHEMBL82242
CHEMBL479232 CHEMBL1437696 |
C012526
|
14 / 2 / 2 | 2 / 1 | No. 2 | No. 15 |
|
|
C00005382
|
Quercimeritrin
/ Quercetin 7-glucoside / Quercetin 7-O-beta-D-glucoside |
CHEMBL248726
|
C089996
|
No. 2 | No. 15 |
|
||
|
C00005113
|
Pulcherrimin
/ 7-Hydroxy-9-methoxy-1,3-dioxolo[7,8][2]benzopyrano[4,3-b][1]benzopyran-6(4H)-one |
No. 3 | No. 15 |
|
||||
|
C00005114
|
6-Methoxypulcherrimin
/ 7-Hydroxy-8,9-dimethoxy-1,3-dioxolo[7,8][2]benzopyrano[4,3-b][1]benzopyran-6(4H)-one |
No. 3 | No. 15 |
|
||||
|
C00003750
|
Lupeol acetate
|
CHEMBL453802
CHEMBL1097034 |
C055329
|
1 / 0 / 0 | No. 23 | No. 51 |
|
|
|
C00003749
|
Lupeol
/ Lupenol / (+)-Lupenol |
CHEMBL289191
CHEMBL459702 |
C010480
|
3 / 0 / 0 | 2 / 6 | No. 23 | No. 51 |
|
|
C00001028
|
5,7-Dimethoxyflavone
/ chrysin 5,7-dimethyl ether |
CHEMBL275391
|
C060298
|
14 / 13 / 13 | 2 / 3 | No. 35 | No. 15 |
|
|
C00020637
|
Leucodelphinidin
|
CHEMBL460265
|
C031451
|
No. 52 | No. 14 |
|
||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023770
|
Sitosterol
/ Stigmasta-5,22-dien-3beta-ol / (24R)24-Ethylcholesta-5,22-dien-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00014128
|
(2S)-5,7-Dimethoxy-3',4'-methylenedioxyflavanone
|
No. 77 | No. 14 |
|
||||
|
C00014430
|
2'-Hydroxy-2,3,4',6'-tetramethoxychalcone
|
CHEMBL1254091
|
1 / 5 / 5 | No. 79 |
|
|||
|
C00006928
|
Isoliquiritigenin 4'-methyl ether
|
CHEMBL2333805
|
No. 92 | No. 13 |
|
|||
|
C00020065
|
alpha-Cadinol
/ (-)-alpha-Cadinol |
CHEMBL486795
|
No. 205 | No. 38 |
|
|||
|
C00043973
|
Teucladiol
|
No. 205 | No. 38 |
|
||||
|
C00012483
|
Betula pubescens
/ Caryophyllene oxide / trans-Caryophyllene oxide / beta-Caryophyllene epoxide / (-)-Epoxydihydrocaryophyllene / 6,7-Epoxy-3(15)-caryophyllene / (-)-beta-Caryophyllene epoxide / 4beta,5alpha-Epoxycaryophyllene / Caryophyllene 4beta,5alpha-epoxide |
CHEMBL399036
CHEMBL508894 CHEMBL479134 CHEMBL1513806 CHEMBL1553274 |
3 / 1 / 3 | No. 500 |
|
|||
|
C00030519
|
Isobonducellin
/ (Z)-7-Hydroxy-3-(4'-methoxybenzylidene)chroman-4-one |
CHEMBL399036
CHEMBL508894 CHEMBL479134 CHEMBL1513806 CHEMBL1553274 |
3 / 1 / 3 | No. 500 |
|
|||
|
C00003467
|
Phytol
/ trans-Phytol |
CHEMBL390773
CHEMBL1644111 |
D010836
|
0 / 5 | No. 641 | No. 38 |
|
|
|
C00038320
|
7-Hydroxycadalene
|
CHEMBL451475
|
No. 647 | No. 38 |
|
|||
|
C00002647
|
Gallic acid
|
CHEMBL288114
|
D005707
|
42 / 53 / 68 | 52 / 16 | No. 817 | No. 81 |
|
|
C00000149
|
Spathulenol
|
CHEMBL518542
CHEMBL1774433 |
C013258
|
No. 1603 |
|
|||
|
C00031643
|
Caesaldekarin A
/ (+)-Caesaldekarin A |
No. 1776 |
|
|||||
|
C00001202
|
Sebacic acid
|
CHEMBL1232164
|
C011107
|
1 / 0 | No. 1853 |
|
||
|
C00000258
|
2,6-Dimethoxy-p-benzoquinone
|
CHEMBL448515
|
C030511
|
22 / 32 / 55 | No. 2517 |
|
||
|
C00048518
|
Pulcherrin B
/ (+)-Pulcherrin B |
No. 2593 |
|
|||||
|
C00048440
|
Isovouacapenol C
/ (-)-Isovouacapenol C |
CHEMBL522805
|
No. 2593 |
|
||||
|
C00048517
|
Pulcherrin A
/ (+)-Pulcherrin A |
No. 2593 |
|
|||||
|
C00048519
|
Pulcherrin C
/ (+)-Pulcherrin C |
No. 2593 |
|
|||||
|
C00020039
|
Bonducellin
/ (E)-7-Hydroxy-3-(4'-methoxybenzylidene)chroman-4-one |
CHEMBL450675
CHEMBL1253830 |
8 / 25 / 23 | No. 2899 |
|
|||
|
C00020222
|
Intricatin
/ 8-Methoxybonducellin |
No. 2899 |
|
|||||
|
C00031915
|
Isovouacapenol E
/ (-)-Isovouacapenol E |
No. 3258 |
|
|||||
|
C00048516
|
Pulcherrimin E
|
No. 3258 |
|
|||||
|
C00048515
|
Pulcherrimin C
|
No. 3258 |
|
|||||
|
C00048490
|
Neocaesalpin R
/ (+)-Neocaesalpin R |
No. 3832 |
|
|||||
|
C00048489
|
Neocaesalpin Q
/ (+)-Neocaesalpin Q |
No. 3832 |
|
|||||
|
C00048488
|
Neocaesalpin P
/ (+)-Neocaesalpin P |
No. 3832 |
|
|||||
|
C00045389
|
Pulcherralpin
|
CHEMBL455618
|
C050243
|
No. 6713 |
|
Human Protein / Gene in interactions
109 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000258 C00003672 C00005413 C00012483 C00023770 C00030519 | 0 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000258 C00001028 C00002647 C00005374 C00005413 C00005730 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001028 C00002647 C00005374 C00005413 C00005730 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000258 C00001028 C00005374 C00005730 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001028 C00002647 C00005374 C00005730 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002647 C00005374 C00005413 C00005730 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002647 C00003672 C00005413 C00023770 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 C00012483 C00023770 C00030519 | 1 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 C00012483 C00023770 C00030519 | 0 / 1 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00005413 C00005730 C00023770 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002647 C00003672 C00005730 C00023770 | 1 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000258 C00002647 C00005413 C00005730 | 4 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002647 C00005413 C00005730 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003749 C00003750 C00005413 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000258 C00002647 C00005413 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000258 C00005374 C00005730 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00003749 C00023770 | 0 / 0 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 C00005413 C00023770 | 4 / 2 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002647 C00005374 C00005730 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00005374 C00005730 | 0 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | C00014430 C00020039 | 5 / 5 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 C00023770 | 1 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 C00023770 | 3 / 2 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00005374 C00005413 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000258 C00002647 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005413 C00005730 | 1 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 C00023770 | 1 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002647 C00005413 | 0 / 3 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 C00023770 | 2 / 0 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005374 C00005730 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005413 C00005730 | 1 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00000258 C00005730 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00000258 C00001028 | 2 / 5 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00000258 C00002647 | 4 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000258 C00002647 | 2 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00001028 C00005413 | 2 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002647 C00005413 | 3 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000258 C00001028 | 1 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 C00023770 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000258 C00002647 | 7 / 37 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 C00023770 | 0 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00002647 C00020039 | 2 / 3 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 C00023770 | 1 / 0 |
| P00734 | Prothrombin | S1A | C00003672 C00023770 | 4 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000258 C00005730 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005374 C00005730 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 C00023770 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002647 C00005374 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000258 C00001028 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005374 C00005730 | 1 / 1 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002647 | 0 / 0 |
| P27487 | Dipeptidyl peptidase 4 | S9B | C00005413 | 0 / 1 |
| P10145 | Interleukin-8 | Secreted protein | C00002647 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00000258 | 7 / 3 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00005413 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00001028 | 4 / 2 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00001028 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00005413 | 0 / 0 |
| P51843 | Nuclear receptor subfamily 0 group B member 1 | Nuclear hormone receptor subfamily 0 group B member 1 | C00001028 | 2 / 2 |
| O75496 | Geminin | Unclassified protein | C00000258 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002647 | 0 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00000258 | 2 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00020039 | 0 / 0 |
| P06276 | Cholinesterase | Hydrolase | C00005413 | 0 / 0 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00020039 | 1 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002647 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002647 | 1 / 2 |
| P16581 | E-selectin | Adhesion | C00002647 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002647 | 0 / 1 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002647 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002647 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002647 | 2 / 2 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00001028 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001028 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003749 | 0 / 0 |
| P12821 | Angiotensin-converting enzyme | M2 | C00002647 | 4 / 2 |
| P22303 | Acetylcholinesterase | Hydrolase | C00005413 | 1 / 0 |
| P11362 | Fibroblast growth factor receptor 1 | Fgfr | C00020039 | 4 / 5 |
| P14151 | L-selectin | Adhesion | C00002647 | 0 / 0 |
| P16109 | P-selectin | Adhesion | C00002647 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00020039 | 1 / 8 |
| P78536 | Disintegrin and metalloproteinase domain-containing protein 17 | M12B | C00002647 | 1 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00005413 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002647 | 1 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002647 | 11 / 10 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002647 | 5 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00000258 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005730 | 0 / 0 |
| P10721 | Mast/stem cell growth factor receptor Kit | Pdgfr | C00020039 | 4 / 3 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002647 | 0 / 0 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005730 | 1 / 1 |
| P48147 | Prolyl endopeptidase | S9A | C00005413 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00002647 | 0 / 0 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002647 | 1 / 1 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002647 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002647 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002647 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00005730 | 0 / 0 |
| Q2TB90 | Putative hexokinase HKDC1 | Enzyme | C00000258 | 0 / 0 |
| P21802 | Fibroblast growth factor receptor 2 | TK tyrosine-protein kinase TLK subfamily | C00020039 | 9 / 3 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002647 | 3 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00000258 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005730 | 0 / 0 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | C00005374 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00005730 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00005730 | 1 / 4 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00005413 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00000258 | 2 / 1 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00001028 | 1 / 1 |
73 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001028
C00005374
C00005413
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001028
C00005374
C00005413
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002647
C00005413
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00002647
C00005413
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00002647
C00005413
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00002647
C00005413
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00002647
C00005413
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002647
C00005413
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00002647
C00005413
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00002647
C00005413
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002647
C00005413
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002647
C00005413
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002647
C00005413
|
| 7224 | TRPC5, TRP5 | transient receptor potential cation channel, subfamily C, member 5 |
C00002647
|
| 545 | ATR, FCTCS, FRP1, MEC1, SCKL, SCKL1 | ataxia telangiectasia and Rad3 related (EC:2.7.11.1) |
C00002647
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002647
|
| 898 | CCNE1, CCNE | cyclin E1 |
C00002647
|
| 998 | CDC42, CDC42Hs, G25K | cell division cycle 42 |
C00002647
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00002647
|
| 1027 | CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1 | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
C00002647
|
| 1147 | CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 | conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10) |
C00002647
|
| 7852 | CXCR4, CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM | chemokine (C-X-C motif) receptor 4 |
C00002647
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002647
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00002647
|
| 2551 | GABPA, E4TF1-60, E4TF1A, NFT2, NRF2, NRF2A, RCH04A07 | GA binding protein transcription factor, alpha subunit 60kDa |
C00002647
|
| 2885 | GRB2, ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2 | growth factor receptor-bound protein 2 |
C00002647
|
| 3551 | IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) |
C00002647
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00002647
|
| 338 | APOB, FLDB, LDLCQ4 | apolipoprotein B |
C00002647
|
| 3949 | LDLR, FH, FHC, LDLCQ2 | low density lipoprotein receptor |
C00002647
|
| 5604 | MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 | mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) |
C00002647
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00002647
|
| 25 | ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl | c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) |
C00002647
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002647
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002647
|
| 4255 | MGMT | O-6-methylguanine-DNA methyltransferase (EC:2.1.1.63) |
C00002647
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00002647
|
| 4316 | MMP7, MMP-7, MPSL1, PUMP-1 | matrix metallopeptidase 7 (matrilysin, uterine) (EC:3.4.24.23) |
C00002647
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00002647
|
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00002647
|
| 5578 | PRKCA, AAG6, PKC-alpha, PKCA, PRKACA | protein kinase C, alpha (EC:2.7.11.13) |
C00002647
|
| 5591 | PRKDC, DNA-PKcs, DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350 | protein kinase, DNA-activated, catalytic polypeptide (EC:2.7.11.1) |
C00002647
|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00002647
|
| 5879 | RAC1, Rac-1, TC-25, p21-Rac1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) |
C00002647
|
| 19412 |
C00002647
|
||
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00003749
|
| 387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00002647
|
| 388 | RHOB, ARH6, ARHB, MST081, MSTP081, RHOH6 | ras homolog family member B |
C00002647
|
| 6195 | RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 (EC:2.7.11.1) |
C00002647
|
| 9252 | RPS6KA5, MSK1, MSPK1, RLPK | ribosomal protein S6 kinase, 90kDa, polypeptide 5 (EC:2.7.11.1) |
C00002647
|
| 6622 | SNCA, NACP, PARK1, PARK4, PD1 | synuclein, alpha (non A4 component of amyloid precursor) |
C00002647
|
| 6817 | SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) |
C00002647
|
| 128 | ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR | alcohol dehydrogenase 5 (class III), chi polypeptide (EC:1.1.1.1 1.1.1.284) |
C00001202
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002647
|
| 613 | BCR, ALL, BCR1, CML, D22S11, D22S662, PHL | breakpoint cluster region (EC:2.7.11.1) |
C00002647
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00003749
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00002647
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00005413
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00005413
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00005413
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00005413
|
| 873 | CBR1, CBR, SDR21C1, hCBR1 | carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) |
C00005413
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00005413
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00005413
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00005413
|
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) |
C00005413
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00005413
|
| 3480 | IGF1R, CD221, IGFIR, IGFR, JTK13 | insulin-like growth factor 1 receptor (EC:2.7.10.1) |
C00005413
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00005413
|
| 3667 | IRS1, HIRS-1 | insulin receptor substrate 1 |
C00005413
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00005413
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00005413
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00005413
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (123)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300018 | 46,xy sex reversal 2; srxy2 |
P51843
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #300200 | Adrenal hypoplasia, congenital; ahc |
P51843
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #207410 | Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 |
P21802
|
| #101200 | Apert syndrome |
P21802
|
| #609135 | Aplastic anemia |
O14746
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #123790 | Beare-stevenson cutis gyrata syndrome; bstvs |
P21802
|
| #614592 | Bent bone dysplasia syndrome; bbds |
P21802
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
Q14191 |
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #123500 | Crouzon syndrome |
P21802
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #606764 | Gastrointestinal stromal tumor; gist |
P10721
|
| #143500 | Gilbert syndrome |
P22309
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #602089 | Hemangioma, capillary infantile |
P35968
|
| #614519 | Hemorrhage, intracerebral, susceptibility to; ich |
P12821
|
| #114550 | Hepatocellular carcinoma |
P08581
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #147950 | Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 |
P11362
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #614328 | Inflammatory skin and bowel disease, neonatal; nisbd |
P78536
|
| #123150 | Jackson-weiss syndrome; jws |
P21802
|
| #149730 | Lacrimoauriculodentodigital syndrome; ladd |
P21802
|
| #601626 | Leukemia, acute myeloid; aml |
P10721
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #211980 | Lung cancer |
P00533
P04637 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #612624 | Microvascular complications of diabetes, susceptibility to, 3; mvcd3 |
P12821
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #166250 | Osteoglophonic dysplasia; ogd |
P11362
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #101600 | Pfeiffer syndrome |
P11362
P21802 |
| #172700 | Pick disease of brain |
P10636
|
| #172800 | Piebald trait; pbt |
P10721
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #267430 | Renal tubular dysgenesis; rtd |
P12821
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #609579 | Scaphocephaly, maxillary retrusion, and mental retardation |
P21802
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
P12821 P16109 |
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #273300 | Testicular germ cell tumor; tgct |
P10721
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #190440 | Trigonocephaly 1; trigno1 |
P11362
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (108)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00764 | Cri du chat syndrome |
O14746
(related)
|
| H01132 | Aplastic anemia (AA) |
O14746
(related)
|
| H01299 | Idiopathic pulmonary fibrosis |
O14746
(related)
|
| H00022 | Bladder cancer |
O14746
(marker)
P00533 (related) P04637 (related) |
| H00024 | Prostate cancer |
O14746
(marker)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) P08581 (related) Q16790 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04637 (related) P08581 (related) P21802 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04637 (related) |
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P27487 (marker) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P08581 (related) P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P10721
(related)
P10721 (marker) Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00170 | Piebaldism |
P10721
(related)
|
| H00023 | Testicular cancer |
P10721
(marker)
|
| H00255 | Hypogonadotropic hypogonadism |
P11362
(related)
|
| H00443 | Osteoglophonic dysplasia (OD) |
P11362
(related)
|
| H00458 | Craniosynostosis |
P11362
(related)
P21802 (related) |
| H00516 | Isolated orofacial clefts |
P11362
(related)
|
| H01207 | Trigonocephaly |
P11362
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00083 | Allograft rejection |
P12821
(related)
|
| H00575 | Renal tubular dysgenesis |
P12821
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00642 | Lacrimo-auriculo-dento-digital syndrome (LADD) |
P21802
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P51843
(related)
|
| H00607 | 46,XY disorders of sex development (Disorders of gonadal development) |
P51843
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
38 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D006937 | Hypercholesterolemia |
C00003749
C00002647 |
| D009069 | Movement Disorders |
C00002647
|
| D006528 | Carcinoma, Hepatocellular |
C00003749
|
| D009374 | Neoplasms, Experimental |
C00003749
|
| D012878 | Skin Neoplasms |
C00003749
|
| D014947 | Wounds and Injuries |
C00003749
|
| D010146 | Pain |
C00005374
|
| D004938 | Esophageal Neoplasms |
C00001028
|
| D008114 | Liver Neoplasms, Experimental |
C00001028
|
| D011230 | Precancerous Conditions |
C00001028
|
| D003921 | Diabetes Mellitus, Experimental |
C00002647
|
| D050171 | Dyslipidemias |
C00002647
|
| D005234 | Fatty Liver |
C00002647
|
| D018149 | Glucose Intolerance |
C00002647
|
| D006943 | Hyperglycemia |
C00002647
|
| D006949 | Hyperlipidemias |
C00002647
|
| D015228 | Hypertriglyceridemia |
C00002647
|
| D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
C00002647
|
| D008546 | Melanoma, Experimental |
C00002647
|
| D009202 | Cardiomyopathies |
C00003749
|
| D009203 | Myocardial Infarction |
C00002647
|
| D009361 | Neoplasm Invasiveness |
C00002647
|
| D009362 | Neoplasm Metastasis |
C00002647
|
| D012516 | Osteosarcoma |
C00002647
|
| D010182 | Pancreatic Diseases |
C00002647
|
| D056486 | Drug-Induced Liver Injury |
C00003467
|
| D006965 | Hyperplasia |
C00003467
|
| D006984 | Hypertrophy |
C00003467
|
| D009336 | Necrosis |
C00003467
|
| D015431 | Weight Loss |
C00003467
|
| D001424 | Bacterial Infections |
C00005413
|
| D003092 | Colitis |
C00005413
|
| D004409 | Dyskinesia, Drug-Induced |
C00005413
|
| D015212 | Inflammatory Bowel Diseases |
C00005413
|
| D007674 | Kidney Diseases |
C00005413
|
| D028361 | Mitochondrial Diseases |
C00005413
|
| D010243 | Paralysis |
C00005413
|
| D013276 | Stomach Ulcer |
C00005413
|