Species

KNApSAcK Entry

Organism name Macaranga tanarius
Genus Macaranga
Family Euphorbiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Macaranga tanarius
Linked NCBI taxonomy ID 109849
Linked level species

Family

Family in NCBI taxonomy Euphorbiaceae
ID 3977

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (24)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00029329 External link 512 Roseoside
/ Roseoside A
/ Roseoside II
/ (6S,9R)-Roseoside
/ Vomifoliol beta-D-glucopyranoside
C00005413 External link 512 Rutin
/ Birutan
/ 3-Rutinosylquercetin
/ Quercetin 3-O-rutinoside
/ (+)-Quercetin 3-O-rutinoside
/ Quercetin 3-O-beta-rutinoside
/ (+)-Quercetin 3-O-beta-rutinoside
/ 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside
/ Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
CHEMBL32579
CHEMBL310754
CHEMBL182108
CHEMBL226335
CHEMBL502782
CHEMBL1436093
CHEMBL1532989
D012431
25 / 18 / 16 29 / 8 No. 1 No. 15
C00048520 External link 512 Quercetin 3-O-arabinopyranoside
CHEMBL183031
CHEMBL185461
CHEMBL488198
CHEMBL464507
CHEMBL520637
No. 2 No. 15
C00001059 External link 512 Isovitexin
/ Saponaretin
/ Homovitexin
/ 6-C-beta-D-Glucopyranosylapigenin
/ 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL465360
CHEMBL1601394
C049772
28 / 20 / 19 No. 22 No. 15
C00014255 External link 512 Tanariflavanone A
/ 5,3',4'-Trihydroxy-2'-geranyl-(5''-hydroxy-6'',6''-dimethyldihydropyrano[2'',3'':7,6])flavanone
No. 39
C00039686 External link 512 Macaflavanone D
/ (-)-Macaflavanone D
No. 39
C00014254 External link 512 Tanariflavanone B
/ 5,7,4'-Trihydroxy-6-prenyl-6''-methyl,6''-(4-methylpent-3-enyl)-pyrano[2'',3'':3',2']flavanone
CHEMBL486181
CHEMBL572684
No. 39
C00039689 External link 512 Macaflavanone G
/ (+)-Macaflavanone G
No. 39
C00039687 External link 512 Macaflavanone E
/ (+)-Macaflavanone E
No. 39
C00039683 External link 512 Macaflavanone A
/ (+)-Macaflavanone A
CHEMBL575211
No. 39
C00039684 External link 512 Macaflavanone B
/ (+)-Macaflavanone B
CHEMBL573137
No. 39
C00039685 External link 512 (+)-
/ Macaflavanone C
No. 39
C00039688 External link 512 Macaflavanone F
/ (+)-Macaflavanone F
No. 39
C00039891 External link 512 Nymphaeol C
CHEMBL455860
No. 170 No. 14
C00048242 External link 512 (2S,3R)-Dihydrodehydrodiconiferyl alcohol beta-D-glucoside
CHEMBL2336751
No. 193
C00023495 External link 512 Kolavenol
CHEMBL99403
CHEMBL95649
No. 221
C00030507 External link 512 Icariside B5
/ (-)-Icariside B5
No. 225
C00048245 External link 512 (6R,9R)-3-Oxo-alpha-ionol beta-D-glucoside
CHEMBL1808110
No. 225
C00048246 External link 512 (6R,9S)-3-Oxo-alpha-ionol beta-D-glucoside
CHEMBL1808110
No. 225
C00048473 External link 512 Macarangioside F
/ (-)-Macarangioside F
No. 431
C00002500 External link 512 Scopolin
CHEMBL225024
C417572
7 / 3 / 4 No. 491 No. 25
C00030754 External link 512 Methyl gallate
/ Methyl 3,4,5-trihydroxybenzoate
CHEMBL65675
C052082
16 / 15 / 13 No. 1722
C00048472 External link 512 Macarangioside E
/ (+)-Macarangioside E
No. 3482
C00048240 External link 512 (+)-Pinoresinol 4-O-(6''-O-galloyl)-beta-D-glucopyranoside
No. 7556

Human Protein / Gene in interactions

57 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P06746 DNA polymerase beta Enzyme C00001059 C00005413 C00030754 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001059 C00005413 C00030754 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001059 C00005413 C00030754 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00001059 C00005413 C00030754 1 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001059 C00005413 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005413 C00030754 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001059 C00030754 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001059 C00030754 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001059 C00030754 1 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00001059 C00030754 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005413 C00030754 1 / 1
P22303 Acetylcholinesterase Hydrolase C00002500 C00005413 1 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001059 C00030754 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001059 C00030754 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001059 C00005413 1 / 0
P14679 Tyrosinase Oxidoreductase C00005413 4 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00001059 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001059 2 / 2
O43570 Carbonic anhydrase 12 Lyase C00002500 1 / 2
P02768 Serum albumin Secreted protein C00030754 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00005413 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00002500 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005413 0 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001059 7 / 3
Q9Y253 DNA polymerase eta Enzyme C00001059 1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005413 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00030754 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00005413 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00005413 0 / 0
P06276 Cholinesterase Hydrolase C00005413 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00005413 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00002500 0 / 1
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00005413 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005413 2 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001059 0 / 0
P03372 Estrogen receptor NR3A1 C00005413 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00002500 1 / 2
P30989 Neurotensin receptor type 1 Neurotensin receptor C00001059 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00005413 0 / 1
Q9UNA4 DNA polymerase iota Enzyme C00001059 0 / 0
P55789 FAD-linked sulfhydryl oxidase ALR Enzyme C00030754 1 / 0
P02545 Prelamin-A/C Unclassified protein C00030754 11 / 10
P10636 Microtubule-associated protein tau Unclassified protein C00005413 4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001059 0 / 0
P48147 Prolyl endopeptidase S9A C00005413 0 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00002500 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00002500 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001059 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005413 0 / 3
P33527 Multidrug resistance-associated protein 1 drugs C00005413 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001059 1 / 0
O00255 Menin Unclassified protein C00001059 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001059 1 / 2
Q13951 Core-binding factor subunit beta Unclassified protein C00001059 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00001059 1 / 4
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001059 0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001059 2 / 1

29 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
177 AGER, RAGE advanced glycosylation end product-specific receptor C00005413
196 AHR, bHLHe76 aryl hydrocarbon receptor C00005413
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00005413
581 BAX, BCL2L4 BCL2-associated X protein C00005413
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00005413
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00005413
847 CAT catalase (EC:1.11.1.6) C00005413
873 CBR1, CBR, SDR21C1, hCBR1 carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) C00005413
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00005413
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00005413
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005413
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005413
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00005413
2936 GSR glutathione reductase (EC:1.8.1.7) C00005413
3458 IFNG, IFG, IFI interferon, gamma C00005413
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00005413
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00005413
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00005413
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00005413
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00005413
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00005413
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00005413
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00005413
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00005413
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00005413
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00005413
7039 TGFA, TFGA transforming growth factor, alpha C00005413
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00005413
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (50)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#614490 Blood group, junior system; jr Q9UNQ0
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc Q14191
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613076 Myopathy, mitochondrial progressive, with congenital cataract, hearing loss, and developmental delay P55789
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (48)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00032 Thyroid cancer P27487 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00192 Xanthinuria P47989 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001424 Bacterial Infections C00005413
D003092 Colitis C00005413
D004409 Dyskinesia, Drug-Induced C00005413
D015212 Inflammatory Bowel Diseases C00005413
D007674 Kidney Diseases C00005413
D028361 Mitochondrial Diseases C00005413
D010243 Paralysis C00005413
D013276 Stomach Ulcer C00005413