Species

KNApSAcK Entry

Organism name Forsythia suspensa
Genus Forsythia
Family Oleaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Forsythia suspensa
Linked NCBI taxonomy ID 126418
Linked level species

Family

Family in NCBI taxonomy Oleaceae
ID 4144

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (19)

Species Activity
Forsythia suspensa (Thunb.) Vahl Analgesic
Forsythia suspensa (Thunb.) Vahl Anti-itch
Forsythia suspensa (Thunb.) Vahl Antibacterial
Forsythia suspensa (Thunb.) Vahl Antiinflammatory
Forsythia suspensa (Thunb.) Vahl Antinauseant
Forsythia suspensa (Thunb.) Vahl Antioxidant
Forsythia suspensa (Thunb.) Vahl Antipyretic
Forsythia suspensa (Thunb.) Vahl Antiseptic
Forsythia suspensa (Thunb.) Vahl Antitussive
Forsythia suspensa (Thunb.) Vahl Antiviral
Forsythia suspensa (Thunb.) Vahl Bitter
Forsythia suspensa (Thunb.) Vahl Cardiotonic
Forsythia suspensa (Thunb.) Vahl Diuretic
Forsythia suspensa (Thunb.) Vahl Emmenagogue
Forsythia suspensa (Thunb.) Vahl Hepatoprotective
Forsythia suspensa (Thunb.) Vahl Hypotensive
Forsythia suspensa (Thunb.) Vahl Laxative
Forsythia suspensa (Thunb.) Vahl Tonic
Forsythia suspensa (Thunb.) Vahl Uterotonic

Metabolite list (13)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005413 External link 512 Rutin
/ Birutan
/ 3-Rutinosylquercetin
/ Quercetin 3-O-rutinoside
/ (+)-Quercetin 3-O-rutinoside
/ Quercetin 3-O-beta-rutinoside
/ (+)-Quercetin 3-O-beta-rutinoside
/ 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside
/ Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
CHEMBL32579
CHEMBL310754
CHEMBL182108
CHEMBL226335
CHEMBL502782
CHEMBL1436093
CHEMBL1532989
D012431
25 / 18 / 16 29 / 8 No. 1 No. 15
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
CHEMBL56615
CHEMBL168
CHEMBL180553
CHEMBL365375
CHEMBL486382
CHEMBL1413646
CHEMBL1436454
D009828
30 / 8 / 12 21 / 15 No. 13 No. 51
C00002781 External link 512 Suspensaside
C037876
No. 33
C00002744 External link 512 Forsythiaside
/ Forsythoside A
CHEMBL504363
C058049
1 / 0 / 0 No. 33
C00007192 External link 512 (+)-Epipinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
7 / 5 / 6 No. 38 No. 21
C00000647 External link 512 (+)-Phillygenin
CHEMBL457587
No. 38 No. 21
C00007190 External link 512 (+)-Pinoresinol
CHEMBL267963
CHEMBL487611
CHEMBL460862
C103298
7 / 5 / 6 No. 38 No. 21
C00000609 External link 512 (-)-Arctigenin
CHEMBL369142
CHEMBL435734
CHEMBL1966556
C071942
13 / 7 / 6 No. 223 No. 21
C00002778 External link 512 Sinapyl alcohol
CHEMBL1800816
No. 310 No. 6
C00000636 External link 512 (+)-Pinoresinolin
No. 621 No. 21
C00049790 External link 512 Forsythenside A
No. 4239
C00049791 External link 512 Forsythenside B
No. 6142
C00049843 External link 512 Suspenolic acid
No. 7917

Human Protein / Gene in interactions

68 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00005413 C00007190 C00007192 C00019064 0 / 3
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007190 C00007192 C00019064 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00007190 C00007192 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000609 C00019064 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000609 C00005413 0 / 1
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00007190 C00007192 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00005413 C00019064 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00007190 C00007192 0 / 0
P06746 DNA polymerase beta Enzyme C00005413 C00019064 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000609 C00005413 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00007190 C00007192 5 / 3
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00007190 C00007192 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000609 1 / 1
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00019064 0 / 0
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00019064 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00019064 0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005413 1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005413 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00019064 0 / 0
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00019064 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000609 0 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005413 1 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00005413 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00019064 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00019064 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000609 2 / 0
O75496 Geminin Unclassified protein C00019064 0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein C00000609 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00005413 0 / 0
P15121 Aldose reductase Enzyme C00019064 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00019064 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005413 0 / 1
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor C00000609 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00019064 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00005413 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00019064 2 / 2
P14679 Tyrosinase Oxidoreductase C00005413 4 / 2
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00019064 4 / 2
P06276 Cholinesterase Hydrolase C00005413 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00019064 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00019064 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00019064 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005413 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000609 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00005413 3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005413 2 / 0
O15118 Niemann-Pick C1 protein Unclassified protein C00000609 1 / 1
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00019064 0 / 0
P03372 Estrogen receptor NR3A1 C00005413 1 / 1
P22303 Acetylcholinesterase Hydrolase C00005413 1 / 0
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
P17252 Protein kinase C alpha type Alpha C00002744 0 / 0
Q99700 Ataxin-2 Unclassified protein C00000609 1 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00019064 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00005413 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00005413 4 / 3
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00000609 1 / 1
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00019064 0 / 1
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00019064 0 / 0
P48147 Prolyl endopeptidase S9A C00005413 0 / 0
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00019064 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00005413 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00005413 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00005413 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00019064 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00019064 1 / 4
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000609 1 / 0

44 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
177 AGER, RAGE advanced glycosylation end product-specific receptor C00005413 C00019064
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00005413 C00019064
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00005413 C00019064
847 CAT catalase (EC:1.11.1.6) C00005413 C00019064
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00005413 C00019064
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00005413 C00019064
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00005413
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC:3.5.1.98) C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00019064
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00019064
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00019064
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00019064
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00019064
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019064
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00019064
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00019064
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00019064
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00019064
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00019064
196 AHR, bHLHe76 aryl hydrocarbon receptor C00005413
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00019064
581 BAX, BCL2L4 BCL2-associated X protein C00005413
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00005413
873 CBR1, CBR, SDR21C1, hCBR1 carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) C00005413
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00005413
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00005413
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005413
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005413
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00005413
2936 GSR glutathione reductase (EC:1.8.1.7) C00005413
3458 IFNG, IFG, IFI interferon, gamma C00005413
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00005413
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00005413
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00005413
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00005413
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00005413
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00005413
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00005413
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00005413
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00005413
7039 TGFA, TFGA transforming growth factor, alpha C00005413
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (38)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#609338 Carotid intimal medial thickness 1 P37231
#114500 Colorectal cancer; crc P84022
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#611162 Malaria, susceptibility to P35228
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257220 Niemann-pick disease, type c1; npc1 O15118
#163950 Noonan syndrome 1; ns1 Q06124
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (31)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00026 Endometrial Cancer P03372 (marker)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00408 Type I diabetes mellitus P17706 (related)
H00032 Thyroid cancer P27487 (marker)
P37231 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00017 Esophageal cancer P35228 (related)
P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00420 Familial partial lipodystrophy (FPL) P37231 (related)
H00192 Xanthinuria P47989 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

22 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007674 Kidney Diseases C00019064
C00005413
D009369 Neoplasms C00019064
D050171 Dyslipidemias C00019064
D018149 Glucose Intolerance C00019064
D006949 Hyperlipidemias C00019064
D007249 Inflammation C00019064
D002252 Carbon Tetrachloride Poisoning C00019064
D008103 Liver Cirrhosis C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D008107 Liver Diseases C00019064
D017202 Myocardial Ischemia C00019064
D056486 Drug-Induced Liver Injury C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064
D001424 Bacterial Infections C00005413
D003092 Colitis C00005413
D004409 Dyskinesia, Drug-Induced C00005413
D015212 Inflammatory Bowel Diseases C00005413
D028361 Mitochondrial Diseases C00005413
D010243 Paralysis C00005413
D013276 Stomach Ulcer C00005413