Species

KNApSAcK Entry

Organism name Achillea millefolium
Genus Achillea
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Achillea millefolium
Linked NCBI taxonomy ID 13329
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Metabolite list (14)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005413 External link 512 Rutin
/ Birutan
/ 3-Rutinosylquercetin
/ Quercetin 3-O-rutinoside
/ (+)-Quercetin 3-O-rutinoside
/ Quercetin 3-O-beta-rutinoside
/ (+)-Quercetin 3-O-beta-rutinoside
/ 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside
/ Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
CHEMBL32579
CHEMBL310754
CHEMBL182108
CHEMBL226335
CHEMBL502782
CHEMBL1436093
CHEMBL1532989
D012431
25 / 18 / 16 29 / 8 No. 1 No. 15
C00003205 External link 512 Achillin
CHEMBL517040
CHEMBL1322934
CHEMBL1741501
C476810
12 / 7 / 10 No. 298 No. 38
C00002724 External link 512 Heriguard
/ Chlorogenic acid
/ 3-O-Caffeoylquinic acid
CHEMBL284616
CHEMBL230481
CHEMBL249450
CHEMBL1332980
CHEMBL1394423
CHEMBL1419611
CHEMBL1473644
CHEMBL1552319
D002726
30 / 19 / 22 37 / 9 No. 314 No. 6
C00001174 External link 512 (-)-Viburnitol
CHEMBL34244
CHEMBL37104
CHEMBL354060
CHEMBL467977
CHEMBL1950778
No. 795
C00000615 External link 512 Caffeic acid
CHEMBL145
CHEMBL1320034
68 / 64 / 63 No. 904 No. 6
C00020476 External link 512 Achillicin
No. 1604
C00011756 External link 512 Millefin
No. 1725
C00002074 External link 512 Stachydrine
CHEMBL394450
CHEMBL1456892
CHEMBL1986864
10 / 8 / 12 No. 2627 No. 1
C00001367 External link 512 Homostachydrine
CHEMBL1184551
No. 2627 No. 1
C00001345 External link 512 (-)-Betonicine
/ 4-Hydroxyproline betaine
CHEMBL1181451
CHEMBL1373466
CHEMBL1996398
7 / 16 / 14 No. 2627 No. 1
C00003114 External link 512 Chamazulene
CHEMBL495665
C013872
No. 3472 No. 38
C00041430 External link 512 Chamazulene carboxylic acid
CHEMBL497088
No. 3472 No. 38
C00001273 External link 512 Anacyclin
No. 3616
C00001555 External link 512 Trigonelline
CHEMBL350675
C009560
3 / 1 / 0 No. 3681 No. 1

Human Protein / Gene in interactions

96 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000615 C00001345 C00002074 C00002724 C00003205 C00005413 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000615 C00001345 C00002074 C00002724 C00003205 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000615 C00001345 C00002074 C00002724 C00003205 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000615 C00001345 C00002074 C00002724 C00003205 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000615 C00001345 C00002074 C00002724 C00003205 0 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000615 C00002724 C00005413 0 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000615 C00002724 C00005413 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000615 C00002724 C00005413 3 / 3
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000615 C00002724 C00005413 0 / 0
O00255 Menin Unclassified protein C00000615 C00002074 C00003205 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000615 C00002074 C00003205 1 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00000615 C00002074 C00002724 3 / 2
P00352 Retinal dehydrogenase 1 Enzyme C00000615 C00002724 C00003205 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000615 C00002724 C00005413 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000615 C00002724 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002724 C00003205 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000615 C00005413 4 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00000615 C00005413 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000615 C00001345 11 / 10
P10253 Lysosomal alpha-glucosidase Hydrolase C00000615 C00005413 1 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000615 C00005413 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00000615 C00001345 3 / 1
P06746 DNA polymerase beta Enzyme C00000615 C00005413 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000615 C00002724 3 / 0
P03372 Estrogen receptor NR3A1 C00000615 C00005413 1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000615 C00002724 2 / 2
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000615 C00002724 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000615 C00002724 1 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000615 C00005413 0 / 0
P14679 Tyrosinase Oxidoreductase C00000615 C00005413 4 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00002074 C00005413 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001555 C00003205 0 / 0
P15121 Aldose reductase Enzyme C00000615 C00002724 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000615 C00002724 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000615 1 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000615 0 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000615 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000615 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002074 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00003205 2 / 0
O75496 Geminin Unclassified protein C00002724 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002724 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00005413 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000615 0 / 0
P10145 Interleukin-8 Secreted protein C00002724 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000615 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005413 0 / 1
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002724 1 / 2
P03956 Interstitial collagenase M10A C00000615 0 / 1
P23280 Carbonic anhydrase 6 Lyase C00000615 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000615 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002724 0 / 1
P11388 DNA topoisomerase 2-alpha Isomerase C00005413 0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002724 0 / 0
P06276 Cholinesterase Hydrolase C00005413 0 / 0
P06280 Alpha-galactosidase A Enzyme C00000615 1 / 1
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00000615 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000615 1 / 8
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005413 1 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000615 0 / 1
P08253 72 kDa type IV collagenase M10A C00000615 1 / 3
Q9GZT9 Egl nine homolog 1 Enzyme C00000615 1 / 1
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005413 2 / 0
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002724 1 / 1
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000615 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000615 2 / 2
Q01453 Peripheral myelin protein 22 Unclassified protein C00000615 5 / 2
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00000615 0 / 0
P22303 Acetylcholinesterase Hydrolase C00005413 1 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000615 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005413 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000615 1 / 2
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00001555 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000615 1 / 0
P14780 Matrix metalloproteinase-9 M10A C00000615 2 / 2
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00000615 4 / 2
P43166 Carbonic anhydrase 7 Lyase C00000615 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002724 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000615 0 / 0
P07451 Carbonic anhydrase 3 Lyase C00000615 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002724 0 / 1
P48147 Prolyl endopeptidase S9A C00005413 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000615 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00000615 1 / 2
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000615 0 / 0
P24298 Alanine aminotransferase 1 Enzyme C00000615 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000615 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002724 3 / 3
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000615 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000615 1 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001555 1 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000615 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00005413 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00000615 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00000615 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00003205 0 / 0

66 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
47 ACLY, ACL, ATPCL, CLATP ATP citrate lyase (EC:2.3.3.8) C00002724
358 AQP1, AQP-CHIP, CHIP28, CO aquaporin 1 C00002724
360 AQP3, AQP-3, GIL aquaporin 3 (Gill blood group) C00002724
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00002724
960 CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 CD44 molecule (Indian blood group) C00002724
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00002724
1277 COL1A1, OI4 collagen, type I, alpha 1 C00002724
4512 COX1, COI, MTCO1, MT-CO1 cytochrome c oxidase subunit I C00002724
114757 CYGB, HGB, STAP cytoglobin C00002724
1830 DSG3, CDHF6, PVA desmoglein 3 C00002724
1950 EGF, HOMG4, URG epidermal growth factor C00002724
2200 FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 fibrillin 1 C00002724
2201 FBN2, CCA, DA9 fibrillin 2 C00002724
2246 FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 fibroblast growth factor 1 (acidic) C00002724
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00002724
3036 HAS1, HAS hyaluronan synthase 1 (EC:2.4.1.212) C00002724
3315 HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 heat shock 27kDa protein 1 C00002724
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00002724
3852 KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A keratin 5 C00002724
4157 MC1R, CMM5, MSH-R, SHEP2 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) C00002724
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002724
5241 PGR, NR3C3, PR progesterone receptor C00002724
8985 PLOD3, LH3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) C00002724
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002724
5886 RAD23A, HHR23A, HR23A RAD23 homolog A (S. cerevisiae) C00002724
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00002724
6256 RXRA, NR2B1 retinoid X receptor, alpha C00002724
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00002724
6716 SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) C00002724
7178 TPT1, HRF, TCTP, p02, p23 tumor protein, translationally-controlled 1 C00002724
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00002724
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00002724
7306 TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase-related protein 1 (EC:1.14.18.-) C00002724
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002724
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002724
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002724
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002724
177 AGER, RAGE advanced glycosylation end product-specific receptor C00005413
196 AHR, bHLHe76 aryl hydrocarbon receptor C00005413
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00005413
581 BAX, BCL2L4 BCL2-associated X protein C00005413
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00005413
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00005413
847 CAT catalase (EC:1.11.1.6) C00005413
873 CBR1, CBR, SDR21C1, hCBR1 carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) C00005413
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00005413
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00005413
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005413
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005413
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00005413
2936 GSR glutathione reductase (EC:1.8.1.7) C00005413
3458 IFNG, IFG, IFI interferon, gamma C00005413
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00005413
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00005413
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00005413
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00005413
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00005413
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00005413
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00005413
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00005413
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00005413
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00005413
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00005413
7039 TGFA, TFGA transforming growth factor, alpha C00005413
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00005413
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (76)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#600807 Asthma, susceptibility to Q13093
#209950 Atypical mycobacteriosis, familial P42224
#614490 Blood group, junior system; jr Q9UNQ0
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#245590 Growth hormone insensitivity with immunodeficiency P51692
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#163950 Noonan syndrome 1; ns1 Q06124
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#278300 Xanthinuria, type i P47989
#112100 Yt blood group antigen P22303

KEGG DISEASE (71)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00032 Thyroid cancer P27487 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

17 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000647 Amnesia C00002724
D056486 Drug-Induced Liver Injury C00002724
D006937 Hypercholesterolemia C00002724
D006951 Hyperlipoproteinemias C00002724
D015228 Hypertriglyceridemia C00002724
D052456 Hypoalphalipoproteinemias C00002724
D008545 Melanoma C00002724
D009336 Necrosis C00002724
D015431 Weight Loss C00002724
D001424 Bacterial Infections C00005413
D003092 Colitis C00005413
D004409 Dyskinesia, Drug-Induced C00005413
D015212 Inflammatory Bowel Diseases C00005413
D007674 Kidney Diseases C00005413
D028361 Mitochondrial Diseases C00005413
D010243 Paralysis C00005413
D013276 Stomach Ulcer C00005413