Prunus mume

• Index
• Plant Species
• Metabolite list (13)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Prunus mume
Genus	Prunus
Family	Rosaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Prunus mume
Linked NCBI taxonomy ID	102107
Linked level	species

Family

Family in NCBI taxonomy	Rosaceae
ID	3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (13)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00013879	Quercetin 3-rhamnosyl-(1->6)-(2''-acetylglucoside) / 3-[[2-O-Acetyl-6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one	CHEMBL446488				No. 1	No. 15
C00013923	Isorhamnetin 3-rhamnosyl-(1->6)-(2''-acetylglucoside) / Quercetin 3'-methyl ether 3-rhamnosyl-(1->6)-(2''-acetylglucoside) / 3-[[2-O-Acetyl-6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one	CHEMBL499959				No. 1	No. 15
C00005413	Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989	D012431	25 / 18 / 16	29 / 8	No. 1	No. 15
C00005412	Quercetin 3-neohesperidoside / Quercetin 3-O-neohesperidoside	CHEMBL499824				No. 1	No. 15
C00005365	Prudomenin					No. 2	No. 15
C00005290	Mumenin					No. 2	No. 15
C00008691	Dihydroprudomenin					No. 12	No. 14
C00045259	Chavicol beta-D-glucoside	CHEMBL179783 CHEMBL1159496				No. 45	No. 72
C00002724	Heriguard / Chlorogenic acid / 3-O-Caffeoylquinic acid	CHEMBL284616 CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319	D002726	30 / 19 / 22	37 / 9	No. 314	No. 6
C00003467	Phytol / trans-Phytol	CHEMBL390773 CHEMBL1644111	D010836		0 / 5	No. 641	No. 38
C00045384	Prunose I					No. 3336
C00031092	Prunose III					No. 3336
C00045385	Prunose II / (+)-Prunose II					No. 3336

Human Protein / Gene in interactions

49 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002724 C00005413	0 / 3
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002724 C00005413	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002724 C00005413	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002724 C00005413	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002724 C00005413	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002724 C00005413	3 / 3
P14679	Tyrosinase	Oxidoreductase	C00005413	4 / 2
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00005413	1 / 1
P16473	Thyrotropin receptor	Glycohormone receptor	C00002724	3 / 2
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00005413	1 / 1
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002724	0 / 1
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00005413	1 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00005413	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002724	0 / 0
O75496	Geminin	Unclassified protein	C00002724	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00002724	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P15121	Aldose reductase	Enzyme	C00002724	0 / 0
P10145	Interleukin-8	Secreted protein	C00002724	0 / 0
P27487	Dipeptidyl peptidase 4	S9B	C00005413	0 / 1
P40763	Signal transducer and activator of transcription 3	Transcription Factor	C00002724	1 / 2
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00005413	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00002724	0 / 1
P06746	DNA polymerase beta	Enzyme	C00005413	0 / 0
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00002724	0 / 0
P06276	Cholinesterase	Hydrolase	C00005413	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00005413	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002724	0 / 0
Q13093	Platelet-activating factor acetylhydrolase	Enzyme	C00002724	3 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00005413	2 / 0
P51692	Signal transducer and activator of transcription 5B	Unclassified protein	C00002724	1 / 1
P03372	Estrogen receptor	NR3A1	C00005413	1 / 1
P22303	Acetylcholinesterase	Hydrolase	C00005413	1 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002724	1 / 1
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00002724	2 / 2
O75164	Lysine-specific demethylase 4A	Enzyme	C00002724	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002724	1 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00005413	4 / 3
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00002724	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002724	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00002724	0 / 1
P48147	Prolyl endopeptidase	S9A	C00005413	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00005413	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00002724	0 / 0
P42224	Signal transducer and activator of transcription 1-alpha/beta	Unclassified protein	C00002724	3 / 3
P33527	Multidrug resistance-associated protein 1	drugs	C00005413	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002724	1 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002724	0 / 0

66 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
47	ACLY, ACL, ATPCL, CLATP	ATP citrate lyase (EC:2.3.3.8)	C00002724
358	AQP1, AQP-CHIP, CHIP28, CO	aquaporin 1	C00002724
360	AQP3, AQP-3, GIL	aquaporin 3 (Gill blood group)	C00002724
367	AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM	androgen receptor	C00002724
960	CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1	CD44 molecule (Indian blood group)	C00002724
999	CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO	cadherin 1, type 1, E-cadherin (epithelial)	C00002724
1277	COL1A1, OI4	collagen, type I, alpha 1	C00002724
4512	COX1, COI, MTCO1, MT-CO1	cytochrome c oxidase subunit I	C00002724
114757	CYGB, HGB, STAP	cytoglobin	C00002724
1830	DSG3, CDHF6, PVA	desmoglein 3	C00002724
1950	EGF, HOMG4, URG	epidermal growth factor	C00002724
2200	FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2	fibrillin 1	C00002724
2201	FBN2, CCA, DA9	fibrillin 2	C00002724
2246	FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1	fibroblast growth factor 1 (acidic)	C00002724
2896	GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN	granulin	C00002724
3036	HAS1, HAS	hyaluronan synthase 1 (EC:2.4.1.212)	C00002724
3315	HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27	heat shock 27kDa protein 1	C00002724
3552	IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1	interleukin 1, alpha	C00002724
3852	KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A	keratin 5	C00002724
4157	MC1R, CMM5, MSH-R, SHEP2	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	C00002724
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00002724
5241	PGR, NR3C3, PR	progesterone receptor	C00002724
8985	PLOD3, LH3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4)	C00002724
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00002724
5886	RAD23A, HHR23A, HR23A	RAD23 homolog A (S. cerevisiae)	C00002724
5914	RARA, NR1B1, RAR	retinoic acid receptor, alpha	C00002724
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00002724
6649	SOD3, EC-SOD	superoxide dismutase 3, extracellular (EC:1.15.1.1)	C00002724
6716	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22)	C00002724
7178	TPT1, HRF, TCTP, p02, p23	tumor protein, translationally-controlled 1	C00002724
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00002724
7299	TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3	tyrosinase (EC:1.14.18.1)	C00002724
7306	TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN	tyrosinase-related protein 1 (EC:1.14.18.-)	C00002724
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002724
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00002724
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002724
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002724
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00005413
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00005413
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00005413
581	BAX, BCL2L4	BCL2-associated X protein	C00005413
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00005413
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00005413
847	CAT	catalase (EC:1.11.1.6)	C00005413
873	CBR1, CBR, SDR21C1, hCBR1	carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)	C00005413
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00005413
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00005413
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00005413
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00005413
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00005413
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00005413
3458	IFNG, IFG, IFI	interferon, gamma	C00005413
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00005413
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00005413
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00005413
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00005413
3667	IRS1, HIRS-1	insulin receptor substrate 1	C00005413
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00005413
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00005413
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00005413
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00005413
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00005413
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00005413
7039	TGFA, TFGA	transforming growth factor, alpha	C00005413
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00005413
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions