Senecio viravira

• Index
• Plant Species
• Metabolite list (9)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Senecio viravira
Genus	Senecio
Family	Asteraceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Senecio
Linked NCBI taxonomy ID	18794
Linked level	genus

Family

Family in NCBI taxonomy	Asteraceae
ID	4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (9)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005413	Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989	D012431	25 / 18 / 16	29 / 8	No. 1	No. 15
C00005374	Quercetin	CHEMBL82242 CHEMBL479232 CHEMBL1437696	C012526	14 / 2 / 2	2 / 1	No. 2	No. 15
C00003737	alpha-Amyrin / alpha-Amyrine / alpha-Amyrenol					No. 23	No. 51
C00003738	beta-Amyrin / beta-Amirin / beta-Amyrine / beta-Amyrenol		C036380		0 / 4	No. 23	No. 51
C00003647	Campesterol / 24alpha-Methylcholesterol / (24R)24-Methylcholest-5-en-3beta-ol	CHEMBL520535 CHEMBL485421 CHEMBL1836653	C021273			No. 53	No. 11
C00023774	Fucostanol / Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol	CHEMBL66943 CHEMBL186373 CHEMBL400247 CHEMBL1568947	D013265	5 / 0 / 0	1 / 0	No. 53	No. 11
C00003672	Sitosterol / beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol	CHEMBL221542 CHEMBL1398443 CHEMBL1875388		17 / 19 / 12		No. 53	No. 11
C00002078	Anacrotine		C053598			No. 622	No. 2
C00034076	Neoplatyphylline	CHEMBL1585045		4 / 0 / 0		No. 1044	No. 2

Human Protein / Gene in interactions

54 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P06746	DNA polymerase beta	Enzyme	C00003672 C00005413 C00023774 C00034076	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003672 C00005413	0 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00005374 C00005413	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00005374 C00005413	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00005374 C00005413	0 / 0
P03372	Estrogen receptor	NR3A1	C00003672 C00005413	1 / 1
P14679	Tyrosinase	Oxidoreductase	C00003672 C00005413	4 / 2
P11388	DNA topoisomerase 2-alpha	Isomerase	C00005413 C00023774	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00005374 C00005413	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00005374	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00003672	3 / 2
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00034076	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00023774	0 / 0
P08183	Multidrug resistance protein 1	drug	C00003672	1 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003672	0 / 1
P07237	Protein disulfide-isomerase	Enzyme	C00005374	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00005413	1 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00005413	1 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00005374	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00005374	0 / 0
O75496	Geminin	Unclassified protein	C00034076	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P15121	Aldose reductase	Enzyme	C00005374	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003672	0 / 0
P27487	Dipeptidyl peptidase 4	S9B	C00005413	0 / 1
Q9Y253	DNA polymerase eta	Enzyme	C00005374	1 / 1
P08047	Transcription factor Sp1	Unclassified protein	C00003672	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00034076	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00005413	0 / 0
P00734	Prothrombin	S1A	C00003672	4 / 2
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003672	1 / 0
P06276	Cholinesterase	Hydrolase	C00005413	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00005413	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003672	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00005413	3 / 3
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00005413	2 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00005413	0 / 3
P09884	DNA polymerase alpha catalytic subunit	Transferase	C00023774	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00005413	1 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003672	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003672	2 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00005374	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00005374	0 / 0
Q9P1W9	Serine/threonine-protein kinase pim-2	Pim	C00005374	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00005413	4 / 3
P48147	Prolyl endopeptidase	S9A	C00005413	0 / 0
P80365	Corticosteroid 11-beta-dehydrogenase isozyme 2	Enzyme	C00003672	1 / 1
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00003672	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00005413	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00005413	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00003672	1 / 1
Q02880	DNA topoisomerase 2-beta	Isomerase	C00023774	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00005374	0 / 0

30 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00005374 C00005413
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00005374 C00005413
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00005413
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00005413
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00005413
581	BAX, BCL2L4	BCL2-associated X protein	C00005413
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00005413
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00005413
847	CAT	catalase (EC:1.11.1.6)	C00005413
873	CBR1, CBR, SDR21C1, hCBR1	carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)	C00005413
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00005413
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00005413
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00005413
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00005413
3458	IFNG, IFG, IFI	interferon, gamma	C00005413
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00005413
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00005413
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00005413
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00005413
3667	IRS1, HIRS-1	insulin receptor substrate 1	C00005413
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00005413
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00005413
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00005413
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00005413
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00005413
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00005413
7039	TGFA, TFGA	transforming growth factor, alpha	C00005413
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00005413
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00005413
10599	SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6	solute carrier organic anion transporter family, member 1B1	C00023774

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions