KCF-S cluster No. 622 (13 metabolites)
Corresponding Phytochemical cluster No. 2
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 76 |
| rosids | 57 |
Cumulative family count
| class name | count |
|---|---|
| Asteraceae | 75 |
| Fabaceae | 57 |
| Orobanchaceae | 1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Pyrrolizidine alkaloids | 8 |
metabolites link (8)
Metabolite list (13)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00002078
|
Anacrotine
|
C053598
|
|
|||
|
C00002092
|
Integerrimine
|
CHEMBL362153
CHEMBL488203 |
8 / 1 / 5 |
|
||
|
C00002109
|
Retrorsine
|
CHEMBL520570
CHEMBL496894 CHEMBL1321908 CHEMBL1599718 |
C003300
|
15 / 4 / 9 | 2 / 0 |
|
|
C00002110
|
Riddelline
|
C013672
|
0 / 15 |
|
||
|
C00002116
|
Senecionine
|
CHEMBL362153
CHEMBL488203 |
C009237
|
8 / 1 / 5 | 1 / 1 |
|
|
C00002117
|
Seneciphylline
|
CHEMBL523911
CHEMBL1396368 CHEMBL1439490 CHEMBL1591009 |
C013678
|
14 / 12 / 13 |
|
|
|
C00002118
|
Senecivernine
|
|
||||
|
C00002127
|
Usaramine
|
CHEMBL520570
CHEMBL496894 CHEMBL1321908 CHEMBL1599718 |
15 / 4 / 9 |
|
||
|
C00026179
|
Acetylgynuramine
/ Gynuramine 19-O-acetate |
|
||||
|
C00026182
|
Seneciphyllinine
/ Acetylseneciphylline / O-Acetylseneciphylline / Seneciphylline acetate |
C066417
|
|
|||
|
C00026183
|
Acetylspartioidine
/ O-Acetylspartioidine / Spartioidine acetate |
|
||||
|
C00026196
|
Gynuramine
/ 19-Hydroxysenecionine |
C036949
|
|
|||
|
C00026229
|
Spartioidine
|
CHEMBL523911
CHEMBL1396368 CHEMBL1439490 CHEMBL1591009 |
14 / 12 / 13 |
|
Human Protein / Gene in interactions
20 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 1 / 4 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 0 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 0 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002092 C00002109 C00002116 C00002127 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002109 C00002117 C00002127 C00026229 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002092 C00002116 C00002117 C00026229 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002109 C00002117 C00002127 C00026229 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002109 C00002117 C00002127 C00026229 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002109 C00002117 C00002127 C00026229 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002109 C00002117 C00002127 C00026229 | 1 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002109 C00002127 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002109 C00002127 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00002109 C00002127 | 1 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002117 C00026229 | 7 / 3 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002092 C00002116 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002117 C00026229 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002117 C00026229 | 2 / 3 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002109 C00002127 | 0 / 0 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00002109
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00002109
|
| 54657 | UGT1A4, HUG-BR2, UDPGT, UDPGT_1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D | UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) |
C00002116
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (13)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (15)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
Diseases related to CTD interactions
16 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00002116
|
| D000236 | Adenoma |
C00002110
|
| D018248 | Adenoma, Liver Cell |
C00002110
|
| D002471 | Cell Transformation, Neoplastic |
C00002110
|
| D003643 | Death |
C00002110
|
| D004487 | Edema |
C00002110
|
| D006394 | Hemangiosarcoma |
C00002110
|
| D006470 | Hemorrhage |
C00002110
|
| D006965 | Hyperplasia |
C00002110
|
| D007938 | Leukemia |
C00002110
|
| D008113 | Liver Neoplasms |
C00002110
|
| D008114 | Liver Neoplasms, Experimental |
C00002110
|
| D008175 | Lung Neoplasms |
C00002110
|
| D009336 | Necrosis |
C00002110
|
| D010939 | Plant Poisoning |
C00002110
|
| D011654 | Pulmonary Edema |
C00002110
|