phytochemical cluster No. 2 (127 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 347 |
| rosids | 118 |
| Liliopsida | 6 |
| Magnoliophyta | 1 |
Cumulative family count
| class name | count |
|---|---|
| Asteraceae | 207 |
| Boraginaceae | 132 |
| Fabaceae | 110 |
| Elaeocarpaceae | 6 |
| Orchidaceae | 5 |
| Apocynaceae | 5 |
| Streptococcaceae | 4 |
| Ceratobasidiaceae | 3 |
| Convolvulaceae | 2 |
| Cobitidae | 2 |
| Amaryllidaceae | 1 |
| Aristolochiaceae | 1 |
| Orobanchaceae | 1 |
| Clavicipitaceae | 1 |
| Myrtaceae | 1 |
| Casuarinaceae | 1 |
KEGG BRITE br08003
Categories (2)
| br08003 Category | # of metabolite |
|---|---|
| Pyrrolizidine alkaloids | 52 |
| Indolizidine alkaloids | 6 |
metabolites link (58)
Metabolite list (127)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
figure |
|---|---|---|---|---|---|---|---|
|
C00042748
|
Parsonsine
|
No. 308 |
|
||||
|
C00026159
|
Neoligularidine
|
No. 308 |
|
||||
|
C00026162
|
Acetylsenkirkine
|
No. 308 |
|
||||
|
C00026163
|
Clivorine
|
C028677
|
5 / 0 | No. 308 |
|
||
|
C00037727
|
Auriculine
|
No. 308 |
|
||||
|
C00002126
|
6-Epicastanospermine
/ (+)-6-Epicastanospermine |
CHEMBL67964
CHEMBL311226 CHEMBL421040 CHEMBL464490 CHEMBL1213468 CHEMBL1438313 CHEMBL1980354 |
14 / 13 / 16 | No. 308 |
|
||
|
C00002077
|
Isolycopsamine
|
No. 308 |
|
||||
|
C00026164
|
Neosenkirkine
|
CHEMBL469650
CHEMBL470059 |
No. 308 |
|
|||
|
C00037342
|
Phalaenopsine T
|
No. 308 |
|
||||
|
C00037252
|
Tussilagine
|
No. 308 |
|
||||
|
C00002121
|
Alexine
|
CHEMBL469429
CHEMBL1552977 CHEMBL2219815 |
2 / 4 / 2 | No. 308 |
|
||
|
C00002111
|
Symphytine
|
C020639
|
No. 308 |
|
|||
|
C00026189
|
Monocrotaline
|
CHEMBL37252
CHEMBL521035 CHEMBL1364165 CHEMBL1997093 CHEMBL2134902 CHEMBL2357897 CHEMBL2360560 |
D016686
|
8 / 12 / 40 | 3 / 13 | No. 308 |
|
|
C00026197
|
7-Tigloylheliotridine
|
No. 308 |
|
||||
|
C00002091
|
Europine
|
CHEMBL526357
CHEMBL1964449 |
No. 308 |
|
|||
|
C00002086
|
Acetyllycopsamine
/ 7-Acetyllycopsamine / Lycopsamine 1-acetate |
No. 308 |
|
||||
|
C00002099
|
Senecivernine
|
No. 308 |
|
||||
|
C00002095
|
Gynuramine
/ 19-Hydroxysenecionine |
C036949
|
No. 308 |
|
|||
|
C00002093
|
Usaramine
|
CHEMBL520570
CHEMBL496894 CHEMBL1321908 CHEMBL1599718 |
15 / 4 / 9 | No. 308 |
|
||
|
C00002090
|
Ilamine
/ (+)-Ilamine |
No. 308 |
|
||||
|
C00026203
|
7-Tigloylretronecine
|
No. 308 |
|
||||
|
C00002092
|
Retrorsine
|
CHEMBL520570
CHEMBL496894 CHEMBL1321908 CHEMBL1599718 |
C003300
|
15 / 4 / 9 | 2 / 0 | No. 622 |
|
|
C00002127
|
Castanospermine
|
CHEMBL67964
CHEMBL311226 CHEMBL421040 CHEMBL464490 CHEMBL1213468 CHEMBL1438313 CHEMBL1980354 |
C037806
|
14 / 13 / 16 | No. 622 |
|
|
|
C00002118
|
7-Angeloyl-9-(2-methylbutyryl)heliotridine
|
No. 622 |
|
||||
|
C00026229
|
Sarracine N-oxide
|
No. 622 |
|
||||
|
C00002117
|
Latifoline
|
No. 622 |
|
||||
|
C00002116
|
Acetyllasiocarpine
/ Lasiocarpine monoacetate |
No. 622 |
|
||||
|
C00002078
|
Heliotrine
|
CHEMBL1474445
CHEMBL1978598 CHEMBL2165593 |
C010178
|
6 / 3 / 4 | No. 622 |
|
|
|
C00002110
|
Symlandine
|
No. 622 |
|
||||
|
C00002109
|
Echihumiline
|
No. 622 |
|
||||
|
C00026196
|
Ruwenine
/ (-)-Ruwenine |
No. 622 |
|
||||
|
C00026179
|
Angularine
|
No. 622 |
|
||||
|
C00026183
|
Othonnine
|
No. 622 |
|
||||
|
C00026182
|
Aucherine
/ (-)-Aucherine |
No. 622 |
|
||||
|
C00026188
|
Globiferine
|
No. 623 |
|
||||
|
C00026180
|
Cropodine
/ 1beta,2-Dihydromonocrotaline |
No. 623 |
|
||||
|
C00002123
|
Australine
|
CHEMBL469429
CHEMBL1552977 CHEMBL2219815 |
C059794
|
2 / 4 / 2 | No. 623 |
|
|
|
C00002124
|
Casuarine
/ (+)-Casuarine |
No. 623 |
|
||||
|
C00002085
|
Acetylintermedine
/ 7-Acetylintermedine / O-Acetylintermedine / Intermedine 1-acetate |
No. 623 |
|
||||
|
C00002122
|
3-epi-Australine
/ 3,7a-Diepialexine |
CHEMBL469429
CHEMBL1552977 CHEMBL2219815 |
2 / 4 / 2 | No. 623 |
|
||
|
C00026170
|
Senecioracenine
|
No. 623 |
|
||||
|
C00026167
|
Ligularizine
/ 12-Epipetasitenine acetate / O-Acetyl-12-epifukinotoxin |
No. 623 |
|
||||
|
C00002098
|
Anacrotine
|
C053598
|
No. 623 |
|
|||
|
C00002097
|
Senecionine
|
CHEMBL362153
CHEMBL488203 |
C009237
|
8 / 1 / 5 | 1 / 1 | No. 623 |
|
|
C00002088
|
3'-Acetylindicine
|
No. 623 |
|
||||
|
C00026166
|
Florosenine
/ Otosenine 12-acetate |
No. 623 |
|
||||
|
C00026158
|
Ligularidine
/ O-Acetylcrotaverrine |
No. 623 |
|
||||
|
C00036643
|
Isoelaeocarpicine
/ (+)-Isoelaeocarpicine |
CHEMBL608811
|
1 / 0 / 0 | No. 677 |
|
||
|
C00036886
|
Isotussilagine
/ (+)-Isotussilagine |
No. 677 |
|
||||
|
C00036617
|
Isoelaeocarpine
/ (+)-Isoelaeocarpine |
CHEMBL608812
CHEMBL608813 |
1 / 0 / 0 | No. 677 |
|
||
|
C00036605
|
(+)-Elaeocarpine
|
CHEMBL608812
CHEMBL608813 |
1 / 0 / 0 | No. 677 |
|
||
|
C00036523
|
Nemorensine
|
CHEMBL507995
|
No. 677 |
|
|||
|
C00002075
|
Lycopsamine
|
CHEMBL445876
CHEMBL471483 CHEMBL450265 |
No. 677 |
|
|||
|
C00036485
|
Mulgediifoline
|
CHEMBL507995
|
No. 677 |
|
|||
|
C00002050
|
Rinderine
|
CHEMBL445876
CHEMBL471483 CHEMBL450265 |
No. 677 |
|
|||
|
C00002028
|
Morifoline
|
CHEMBL445876
CHEMBL471483 CHEMBL450265 |
No. 677 |
|
|||
|
C00002023
|
Intermedine
|
CHEMBL445876
CHEMBL471483 CHEMBL450265 |
No. 677 |
|
|||
|
C00002013
|
Indicine
|
CHEMBL445876
CHEMBL471483 CHEMBL450265 |
C018336
|
No. 677 |
|
||
|
C00026213
|
Racemocine
/ Racemocine / (-)-Racemocine / (-)-Racemozine / (-)-9-Tiglylturneforcidine |
No. 838 |
|
||||
|
C00026194
|
Fulvine
|
CHEMBL2003350
|
C041169
|
No. 838 |
|
||
|
C00026217
|
7-Angeloylturneforcidine
/ (+)-7-O-Angeloylturneforcidine |
No. 838 |
|
||||
|
C00026211
|
9-Senecioylretronecine
/ O9-Senecioylretronecine / 9-O-Senecioylretronecine |
No. 838 |
|
||||
|
C00002082
|
Heliohoustine
|
No. 838 |
|
||||
|
C00002084
|
Isoretrohoustine
|
No. 838 |
|
||||
|
C00002119
|
7-Angeloyl-9-(2,3-dihydroxybutyryl)heliotridine
|
No. 838 |
|
||||
|
C00026227
|
Sarracine
|
CHEMBL1979573
|
C011104
|
No. 838 |
|
||
|
C00026215
|
Helifoline
/ Croalbinecine 9-angelate / Helifolinecine 9-angelate |
No. 838 |
|
||||
|
C00002105
|
Acetylspartioidine
/ O-Acetylspartioidine / Spartioidine acetate |
No. 838 |
|
||||
|
C00033612
|
Retroisosenine
|
CHEMBL452758
|
No. 838 |
|
|||
|
C00034076
|
(12S)-12-hydroxyretroisosenine
|
No. 1044 |
|
||||
|
C00026207
|
7-Angeloylheliotridine
/ O7-angelylheliotridine / 7-O-Angeloylheliotridine |
No. 1044 |
|
||||
|
C00026206
|
7-Angelylretronecine
/ 7-Angeloylretronecine / O-7-Angelylretronecine / Retronecine 7-(2-methylcrotonate) |
No. 1044 |
|
||||
|
C00002112
|
7-Angeloylrindrine
/ 7-Angeloylrinderine / O-Demethylheliotrine 7-angelate |
No. 1044 |
|
||||
|
C00026212
|
9-Angelylplatynecine
/ 9-Angeloylplatynecine |
No. 1044 |
|
||||
|
C00026187
|
18-hydroxyjaconine
|
No. 1044 |
|
||||
|
C00002080
|
Supinine
|
No. 1044 |
|
||||
|
C00026225
|
Supinidine
|
C011549
|
No. 1044 |
|
|||
|
C00002107
|
Heliosupine
|
No. 1044 |
|
||||
|
C00026156
|
7a-Epialexaflorine
|
No. 1066 |
|
||||
|
C00002101
|
Spartioidine
|
CHEMBL523911
CHEMBL1396368 CHEMBL1439490 CHEMBL1591009 |
14 / 12 / 13 | No. 1066 |
|
||
|
C00026184
|
Jacoline
|
No. 1066 |
|
||||
|
C00002087
|
7-Acetylechinatine
/ 7-O-Acetylechinatine / Echinatine 1-acetate |
No. 1066 |
|
||||
|
C00026209
|
9-Tiglylretronecine
/ 9-Tigloylretronecine / Retronecine 9-(trans-2-methylcrotonate) |
No. 1066 |
|
||||
|
C00026218
|
Heliotridine
|
No. 1066 |
|
||||
|
C00037757
|
Slaframine
|
C009275
|
No. 1066 |
|
|||
|
C00026195
|
Jacobine
|
CHEMBL1969622
|
C013581
|
No. 1066 |
|
||
|
C00002096
|
Integerrimine
|
CHEMBL362153
CHEMBL488203 |
8 / 1 / 5 | No. 1066 |
|
||
|
C00026177
|
(-)-Iodanthine
|
No. 1265 |
|
||||
|
C00026176
|
Rosmarinine
|
CHEMBL1985054
|
No. 1265 |
|
|||
|
C00033586
|
Racemonine
/ (-)-Racemonine / (-)-9-Senecioyl-(2'-carboethoxy)turneforcidine |
No. 1265 |
|
||||
|
C00026174
|
Ligularinine
/ 12-Epiplatyphylline |
CHEMBL1585045
|
4 / 0 / 0 | No. 1265 |
|
||
|
C00026173
|
Neoplatyphylline
|
CHEMBL1585045
|
4 / 0 / 0 | No. 1265 |
|
||
|
C00026169
|
Doronine
|
No. 1265 |
|
||||
|
C00002079
|
Amabiline
|
No. 1265 |
|
||||
|
C00026178
|
Rosmarinine-2-acetate
/ 2-O-Acetylrosmarinine |
No. 1265 |
|
||||
|
C00033587
|
Racemodine
/ (-)-Racemodine |
No. 1558 |
|
||||
|
C00002100
|
Acetylgynuramine
/ Gynuramine 19-O-acetate |
No. 1558 |
|
||||
|
C00026220
|
Retronecine
|
C014795
|
No. 1558 |
|
|||
|
C00026199
|
7-Angeloylretronecine
|
No. 1558 |
|
||||
|
C00026171
|
Petasitenine
|
CHEMBL511627
CHEMBL1512570 CHEMBL1992587 |
C014738
|
3 / 3 / 8 | No. 1558 |
|
|
|
C00026175
|
Isorosmarinine
|
CHEMBL1985054
|
No. 1558 |
|
|||
|
C00002120
|
Triangularine
|
No. 1675 |
|
||||
|
C00002083
|
Retrohoustine
|
No. 1675 |
|
||||
|
C00026172
|
Platyphylline
|
CHEMBL1585045
|
C008937
|
4 / 0 / 0 | No. 1675 |
|
|
|
C00002108
|
Lasiocarpine
|
CHEMBL498236
CHEMBL1999554 CHEMBL2138247 |
C005136
|
2 / 7 / 3 | No. 1675 |
|
|
|
C00002089
|
Uplandicine
|
No. 1675 |
|
||||
|
C00026165
|
Senkirkine
|
CHEMBL469650
CHEMBL470059 |
C009238
|
No. 1675 |
|
||
|
C00026226
|
NSC 669379
/ Neosarracine |
CHEMBL1979573
|
No. 2382 |
|
|||
|
C00026216
|
7-Angelylhastanecine
|
No. 2382 |
|
||||
|
C00002113
|
Acetylheliosupine
/ 3'-Acetylheliosupine / Acetylcynoglossophine / Heliosupine 3'-acetate / Cynoglossophine acetate |
No. 2382 |
|
||||
|
C00026221
|
Crotanecine
|
No. 2382 |
|
||||
|
C00026222
|
7alpha-Hydroxy-1-methylene-8alpha-pyrrolizidine
|
No. 2382 |
|
||||
|
C00026223
|
7beta-Hydroxy-1-methylene-8alpha-pyrrolizidine
|
No. 2902 |
|
||||
|
C00026155
|
2-Epilentiginosine
/ (-)-2-Epilentiginosine |
CHEMBL63254
|
No. 2902 |
|
|||
|
C00002102
|
Seneciphylline
|
CHEMBL523911
CHEMBL1396368 CHEMBL1439490 CHEMBL1591009 |
C013678
|
14 / 12 / 13 | No. 2902 |
|
|
|
C00026214
|
Macrophylline
|
No. 2902 |
|
||||
|
C00002336
|
Swainsonine
/ (-)-Swainsonine |
CHEMBL63139
CHEMBL292716 CHEMBL302300 CHEMBL65098 CHEMBL371197 |
D017026
|
4 / 2 / 4 | No. 4157 |
|
|
|
C00039438
|
Otonecine
|
No. 4157 |
|
||||
|
C00039437
|
Elaeokanine C
|
No. 4157 |
|
||||
|
C00026208
|
9-Angelylretronecine
/ 9-Angeloylretronecine / 9-O-Angelylretronecine |
No. 4655 |
|
||||
|
C00002125
|
6,7-Diepicastanospermine
/ (+)-6,7-Diepicastanospermine |
CHEMBL67964
CHEMBL311226 CHEMBL421040 CHEMBL464490 CHEMBL1213468 CHEMBL1438313 CHEMBL1980354 |
14 / 13 / 16 | No. 4655 |
|
||
|
C00002106
|
Echimidine
|
No. 5754 |
|
||||
|
C00002081
|
Heleurine
/ (-)-Heleurine / O3-Methylsupinine |
No. 6378 |
|
||||
|
C00002073
|
Echinatine
/ (+)-Echinatine |
CHEMBL445876
CHEMBL471483 CHEMBL450265 |
No. 6472 |
|
|||
|
C00002337
|
Lentiginosine
|
CHEMBL63254
|
C063984
|
No. 6539 |
|
||
|
C00002103
|
Riddelline
|
C013672
|
0 / 15 | No. 7448 |
|
||
|
C00002104
|
Seneciphyllinine
/ Acetylseneciphylline / O-Acetylseneciphylline / Seneciphylline acetate |
C066417
|
No. 7924 |
|
Human Protein / Gene in interactions
37 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002028 C00002090 C00002092 C00002101 C00002105 C00002109 C00002116 C00002117 C00002127 C00026229 C00036605 C00036617 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002028 C00002090 C00002101 C00002109 C00002117 C00002127 C00026229 C00036605 C00036617 | 1 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002028 C00002090 C00002101 C00002109 C00002117 C00002127 C00026229 C00036605 C00036617 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002028 C00002090 C00002101 C00002109 C00002117 C00002127 C00026229 C00036605 C00036617 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002028 C00002090 C00002101 C00002109 C00002117 C00002127 C00026229 C00036605 C00036617 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00002028 C00002097 C00002101 C00002107 C00026212 C00034076 C00036605 C00036617 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002028 C00002107 C00002109 C00002127 C00026212 C00034076 C00036605 C00036617 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002028 C00002092 C00002109 C00002116 C00002127 C00036605 C00036617 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 1 / 4 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002013 C00002023 C00002028 C00036523 C00036605 C00036617 | 1 / 1 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 0 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002092 C00002109 C00002116 C00002117 C00002127 C00026229 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002109 C00002117 C00002127 C00026229 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002092 C00002116 C00002117 C00026229 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00002028 C00002105 C00036605 C00036617 | 2 / 5 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002013 C00002023 C00002101 C00036523 | 3 / 1 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002028 C00002105 C00036605 C00036617 | 1 / 2 |
| P04062 | Glucosylceramidase | Enzyme | C00002028 C00036605 C00036617 | 6 / 4 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002097 C00002117 C00026229 | 7 / 3 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00002336 C00039437 C00039438 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002107 C00026212 C00034076 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00002107 C00026212 C00034076 | 0 / 0 |
| Q14697 | Neutral alpha-glucosidase AB | Enzyme | C00002028 C00036605 C00036617 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00002028 C00036605 C00036617 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002109 C00002127 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002109 C00002127 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00002109 C00002127 | 1 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002117 C00026229 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002092 C00002116 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002117 C00026229 | 2 / 3 |
| O00754 | Lysosomal alpha-mannosidase | Enzyme | C00002075 | 1 / 2 |
| O43561 | Linker for activation of T-cells family member 1 | Unclassified protein | C00002075 | 0 / 0 |
| P43403 | Tyrosine-protein kinase ZAP-70 | Syk | C00002075 | 1 / 2 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002090 | 1 / 1 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002101 | 7 / 37 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002075 | 0 / 1 |
9 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00002101
C00002109
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00002101
C00002109
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002082
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00002082
|
| 54657 | UGT1A4, HUG-BR2, UDPGT, UDPGT_1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D | UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) |
C00002116
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00002082
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002082
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002082
|
| 6532 | SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT | solute carrier family 6 (neurotransmitter transporter), member 4 |
C00002101
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (37)
| OMIM | preferred title | UniProt |
|---|---|---|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #133239 | Esophageal cancer |
P04637
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #248500 | Mannosidosis, alpha b, lysosomal; mansa |
O00754
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #269840 | Selective t-cell defect; stcd |
P43403
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (66)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00139 | alpha-Mannosidosis |
O00754
(related)
|
| H00422 | Glycoproteinoses |
O00754
(related)
|
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P43403 (marker) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
P43403 (related) |
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
Q13148
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|
Diseases related to CTD interactions
29 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00002116
|
| D000236 | Adenoma |
C00002110
|
| D018248 | Adenoma, Liver Cell |
C00002110
|
| D002471 | Cell Transformation, Neoplastic |
C00002110
|
| D003643 | Death |
C00002110
|
| D004487 | Edema |
C00002110
|
| D006394 | Hemangiosarcoma |
C00002110
|
| D006470 | Hemorrhage |
C00002110
|
| D006965 | Hyperplasia |
C00002110
|
| D007938 | Leukemia |
C00002110
|
| D008113 | Liver Neoplasms |
C00002110
|
| D008114 | Liver Neoplasms, Experimental |
C00002110
|
| D008175 | Lung Neoplasms |
C00002110
|
| D009336 | Necrosis |
C00002110
|
| D010939 | Plant Poisoning |
C00002110
|
| D011654 | Pulmonary Edema |
C00002110
|
| D002100 | Cachexia |
C00002101
|
| D006332 | Cardiomegaly |
C00002101
|
| D056486 | Drug-Induced Liver Injury |
C00002101
|
| D006333 | Heart Failure |
C00002101
|
| D006501 | Hepatic Encephalopathy |
C00002101
|
| D006504 | Hepatic Veno-Occlusive Disease |
C00002101
|
| D006976 | Hypertension, Pulmonary |
C00002101
|
| D006984 | Hypertrophy |
C00002101
|
| D017380 | Hypertrophy, Right Ventricular |
C00002101
|
| D007674 | Kidney Diseases |
C00002101
|
| D047508 | Massive Hepatic Necrosis |
C00002101
|
| D018497 | Ventricular Dysfunction, Right |
C00002101
|
| D020257 | Ventricular Remodeling |
C00002101
|