KCF-S cluster No. 838 (11 metabolites)

Corresponding Phytochemical cluster No. 2

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (11)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	44
rosids	2

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Cumulative family count

class name	count
Asteraceae	43
Fabaceae	2
Boraginaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Pyrrolizidine alkaloids	4

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metabolites link (4)

br08003 Category	KEGG ID	KNApSAcK ID
Pyrrolizidine alkaloids	C10282	C00002082
Pyrrolizidine alkaloids	C10286	C00002084
Pyrrolizidine alkaloids	C10359	C00002105
Pyrrolizidine alkaloids	C10396	C00002119

Metabolite list (11)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002082	Clivorine		C028677		5 / 0
C00002084	Doronine
C00002105	Petasitenine	CHEMBL511627 CHEMBL1512570 CHEMBL1992587	C014738	3 / 3 / 8
C00002119	Senkirkine	CHEMBL469650 CHEMBL470059	C009238
C00026194	Florosenine / Otosenine 12-acetate
C00026211	Ligularidine / O-Acetylcrotaverrine
C00026213	Ligularizine / 12-Epipetasitenine acetate / O-Acetyl-12-epifukinotoxin
C00026215	Neoligularidine
C00026217	Neosenkirkine	CHEMBL469650 CHEMBL470059
C00026227	Senecioracenine
C00033612	Acetylsenkirkine

Human Protein / Gene in interactions

3 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002105	0 / 1
O00255	Menin	Unclassified protein	C00002105	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002105	1 / 2

5 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002082
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002082
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00002082
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00002082
1950	EGF, HOMG4, URG	epidermal growth factor	C00002082

Related Diseases

Diseases related to proteins in ChEMBL interactions