PCIDB

KNApSAcK Metabolite C00002082

Metabolite

KNApSAcK Entry

id C00002082
Name Clivorine
CAS RN 33979-15-6
Standard InChI InChI=1S/C21H27NO7/c1-6-15-11-13(2)21(4,29-14(3)23)20(26)27-12-16-7-9-22(5)10-8-17(18(16)24)28-19(15)25/h6-7,11,13,17H,1,8-10,12H2,2-5H3/b15-11-,16-7-/t13-,17-,21+/m1/s1
Standard InChI (Main Layer) InChI=1S/C21H27NO7/c1-6-15-11-13(2)21(4,29-14(3)23)20(26)27-12-16-7-9-22(5)10-8-17(18(16)24)28-19(15)25/h6-7,11,13,17H,1,8-10,12H2,2-5H3

Cluster

Phytochemical cluster No. 2
KCF-S cluster No. 838

Link

ChEMBL

By standard InChI
By standard InChI Main Layer

KEGG

By LinkDB C10282

CTD

By CAS RN C028677

Human Protein / Gene in interaction

CTD interaction (13)

compound gene gene name gene description interaction interaction type form reference
pmid
C028677 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 clivorine results in decreased expression of BCL2L1 protein decreases expression
protein 19437449
C028677 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 EGF protein inhibits the reaction [clivorine results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 19437449
C028677 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) clivorine results in increased cleavage of CASP3 protein increases cleavage
protein 19437449
C028677 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) EGF protein inhibits the reaction [clivorine results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 19437449
C028677 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) clivorine results in increased activity of CASP9 protein increases activity
protein 19437449
C028677 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) EGF protein inhibits the reaction [clivorine results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 19437449
C028677 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic clivorine affects the localization of CYCS protein affects localization
protein 19437449
C028677 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic EGF protein inhibits the reaction [clivorine affects the localization of CYCS protein] affects localization
/ decreases reaction
protein 19437449
C028677 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein inhibits the reaction [clivorine affects the localization of CYCS protein] affects localization
/ decreases reaction
protein 19437449
C028677 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein inhibits the reaction [clivorine results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 19437449
C028677 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein inhibits the reaction [clivorine results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 19437449
C028677 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein inhibits the reaction [clivorine results in increased cleavage of CASP3 protein] decreases reaction
/ increases cleavage
protein 19437449
C028677 1950 EGF
HOMG4
URG
epidermal growth factor EGF protein results in decreased susceptibility to clivorine decreases response to substance
protein 19437449