KCF-S cluster No. 677 (11 metabolites)

Corresponding Phytochemical cluster No. 2

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (11)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	27
asterids	2

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Cumulative family count

class name	count
Fabaceae	25
Convolvulaceae	2
Ceratobasidiaceae	2
Clavicipitaceae	1
Myrtaceae	1
Casuarinaceae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Pyrrolizidine alkaloids	2
Indolizidine alkaloids	3

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Pyrrolizidine alkaloids	C10124	C00002013
Pyrrolizidine alkaloids	C10132	C00002023
Indolizidine alkaloids	C02256	C00002028
Indolizidine alkaloids	C10155	C00002050
Indolizidine alkaloids	C10173	C00002075

Metabolite list (11)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002013	Alexine	CHEMBL469429 CHEMBL1552977 CHEMBL2219815		2 / 4 / 2
C00002023	Australine	CHEMBL469429 CHEMBL1552977 CHEMBL2219815	C059794	2 / 4 / 2
C00002028	Castanospermine	CHEMBL67964 CHEMBL311226 CHEMBL421040 CHEMBL464490 CHEMBL1213468 CHEMBL1438313 CHEMBL1980354	C037806	14 / 13 / 16
C00002050	Lentiginosine	CHEMBL63254	C063984
C00002075	Swainsonine / (-)-Swainsonine	CHEMBL63139 CHEMBL292716 CHEMBL302300 CHEMBL65098 CHEMBL371197	D017026	4 / 2 / 4
C00036485	2-Epilentiginosine / (-)-2-Epilentiginosine	CHEMBL63254
C00036523	3-epi-Australine / 3,7a-Diepialexine	CHEMBL469429 CHEMBL1552977 CHEMBL2219815		2 / 4 / 2
C00036605	6,7-Diepicastanospermine / (+)-6,7-Diepicastanospermine	CHEMBL67964 CHEMBL311226 CHEMBL421040 CHEMBL464490 CHEMBL1213468 CHEMBL1438313 CHEMBL1980354		14 / 13 / 16
C00036617	6-Epicastanospermine / (+)-6-Epicastanospermine	CHEMBL67964 CHEMBL311226 CHEMBL421040 CHEMBL464490 CHEMBL1213468 CHEMBL1438313 CHEMBL1980354		14 / 13 / 16
C00036643	7a-Epialexaflorine
C00036886	Casuarine / (+)-Casuarine

Human Protein / Gene in interactions

19 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002013 C00002023 C00002028 C00036523 C00036605 C00036617	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00002028 C00036605 C00036617	0 / 0
Q14697	Neutral alpha-glucosidase AB	Enzyme	C00002028 C00036605 C00036617	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002028 C00036605 C00036617	1 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00002013 C00002023 C00036523	3 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002028 C00036605 C00036617	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002028 C00036605 C00036617	0 / 1
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002028 C00036605 C00036617	1 / 2
O75496	Geminin	Unclassified protein	C00002028 C00036605 C00036617	0 / 0
P04062	Glucosylceramidase	Enzyme	C00002028 C00036605 C00036617	6 / 4
Q9UBT6	DNA polymerase kappa	Enzyme	C00002028 C00036605 C00036617	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002028 C00036605 C00036617	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002028 C00036605 C00036617	0 / 1
O00255	Menin	Unclassified protein	C00002028 C00036605 C00036617	2 / 5
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002028 C00036605 C00036617	0 / 0
O00754	Lysosomal alpha-mannosidase	Enzyme	C00002075	1 / 2
P06239	Tyrosine-protein kinase Lck	Src	C00002075	0 / 1
O43561	Linker for activation of T-cells family member 1	Unclassified protein	C00002075	0 / 0
P43403	Tyrosine-protein kinase ZAP-70	Syk	C00002075	1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions