PCIDB

KNApSAcK Metabolite C00036605

Metabolite

KNApSAcK Entry

id C00036605
Name 6,7-Diepicastanospermine / (+)-6,7-Diepicastanospermine
CAS RN 130983-46-9
Standard InChI InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4-,5+,6+,7-,8+/m0/s1
Standard InChI (Main Layer) InChI=1S/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2

Cluster

Phytochemical cluster No. 2
KCF-S cluster No. 677

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL67964 CHEMBL311226 CHEMBL421040 CHEMBL464490 CHEMBL1213468 CHEMBL1438313 CHEMBL1980354

KEGG

By LinkDB

CTD

By CAS RN

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Fabaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Castanospermum australe 24962 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1438313 CHEMBL1741321 (1)
1 / 0
P04062 Glucosylceramidase Enzyme CHEMBL311226 CHEMBL421040 CHEMBL1438313 CHEMBL823888 (1) CHEMBL823892 (1)
CHEMBL1613818 (3)
6 / 4
Q14697 Neutral alpha-glucosidase AB Enzyme CHEMBL421040 CHEMBL822533 (1) CHEMBL822538 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL311226 CHEMBL1438313 CHEMBL1614175 (4) CHEMBL1614076 (1)
CHEMBL1614103 (1) CHEMBL1614031 (1)
CHEMBL1614357 (3)
1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1438313 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
O75496 Geminin Unclassified protein CHEMBL311226 CHEMBL2114843 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL311226 CHEMBL1794401 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1438313 CHEMBL1741322 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1438313 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1438313 CHEMBL1741324 (1)
0 / 1
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL311226 CHEMBL1794536 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL1438313 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1438313 CHEMBL1614257 (1)
1 / 3
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL311226 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#168600 Parkinson disease, late-onset; pd P04062

KEGG DISEASE (16)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)