PCIDB

KNApSAcK Metabolite C00002116

Metabolite

KNApSAcK Entry

id C00002116
Name Senecionine
CAS RN 130-01-8
Standard InChI InChI=1S/C18H25NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4-/t11-,14-,15-,18-/m1/s1
Standard InChI (Main Layer) InChI=1S/C18H25NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3

Cluster

Phytochemical cluster No. 2
KCF-S cluster No. 622

Link

ChEMBL

By standard InChI CHEMBL362153
By standard InChI Main Layer CHEMBL362153 CHEMBL488203

KEGG

By LinkDB C06176

CTD

By CAS RN C009237

Species

Summary

Plant class

class name count
asterids 20
rosids 15

Family

family name count
Asteraceae 19
Fabaceae 15
Orobanchaceae 1

List (36)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Castilleja rhexifolia 624188 Orobanchaceae asterids Viridiplantae
Crotalaria juncea 3829 Fabaceae rosids Viridiplantae
Crotalaria micans 1127386 Fabaceae rosids Viridiplantae
Crotalaria trichotoma 452830 Fabaceae rosids Viridiplantae
Lotononis alpina 379258 Fabaceae rosids Viridiplantae
Lotononis caerulescens 76394 Fabaceae rosids Viridiplantae
Lotononis comptonii 76394 Fabaceae rosids Viridiplantae
Lotononis divaricata 508272 Fabaceae rosids Viridiplantae
Lotononis elongata 508273 Fabaceae rosids Viridiplantae
Lotononis involucrata 508284 Fabaceae rosids Viridiplantae
Lotononis lotononoides 140935 Fabaceae rosids Viridiplantae
Lotononis meyeri 508294 Fabaceae rosids Viridiplantae
Lotononis polycephala 508302 Fabaceae rosids Viridiplantae
Lotononis purpurascens 76394 Fabaceae rosids Viridiplantae
Lotononis sericophylla 508312 Fabaceae rosids Viridiplantae
Lotononis trichodes 76394 Fabaceae rosids Viridiplantae
Nardosmia laevigata
Pittocaulon filare 98711 Asteraceae asterids Viridiplantae
Pittocaulon praecox 98712 Asteraceae asterids Viridiplantae
Pittocaulon velatum 98711 Asteraceae asterids Viridiplantae
Senecio argentino 18794 Asteraceae asterids Viridiplantae
Senecio aureus 98688 Asteraceae asterids Viridiplantae
Senecio erraticus 18794 Asteraceae asterids Viridiplantae
Senecio gillesiano 18794 Asteraceae asterids Viridiplantae
Senecio glabellum 18794 Asteraceae asterids Viridiplantae
Senecio glandulosus 18794 Asteraceae asterids Viridiplantae
Senecio illinitus 18794 Asteraceae asterids Viridiplantae
Senecio jacobaea 98722 Asteraceae asterids Viridiplantae
Senecio leucostachys 18794 Asteraceae asterids Viridiplantae
Senecio longibolus 18794 Asteraceae asterids Viridiplantae
Senecio mairetianus 422354 Asteraceae asterids Viridiplantae
Senecio ragonesi 18794 Asteraceae asterids Viridiplantae
Senecio selloi Spreng. De Candolle 18794 Asteraceae asterids Viridiplantae
Senecio subulatus 18794 Asteraceae asterids Viridiplantae
Senecio uspallatensis 18794 Asteraceae asterids Viridiplantae
Senecio vulgaris 76276 Asteraceae asterids Viridiplantae

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P39748 Flap endonuclease 1 Enzyme CHEMBL362153 CHEMBL1794486 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL362153 CHEMBL836230 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL362153 CHEMBL1794483 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL362153 CHEMBL1614211 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL362153 CHEMBL1794536 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL362153 CHEMBL1613829 (1)
0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL362153 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL362153 CHEMBL1613933 (1)
1 / 6

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C009237 54657 UGT1A4
HUG-BR2
UDPGT
UDPGT_1-4
UGT-1D
UGT1-04
UGT1.4
UGT1D
UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) [hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine decreases activity
/ decreases glycosylation
protein 20092275
C009237 54657 UGT1A4
HUG-BR2
UDPGT
UDPGT_1-4
UGT-1D
UGT1-04
UGT1.4
UGT1D
UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) UGT1A4 protein results in increased glycosylation of senecionine increases glycosylation
protein 20092275

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM preferred title UniProt
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196

KEGG DISEASE (5)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D064420 C009237 Drug-Related Side Effects and Adverse Reactions marker/mechanism
21126554