Species

KNApSAcK Entry

Organism name Crotalaria micans
Genus Crotalaria
Family Fabaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Crotalaria micans
Linked NCBI taxonomy ID 1127386
Linked level species

Family

Family in NCBI taxonomy Fabaceae
ID 3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00001019 External link 512 Apiin
CHEMBL1077561
CHEMBL1451695
CHEMBL1535342
C012186
7 / 4 / 7 No. 1 No. 15
C00001059 External link 512 Isovitexin
/ Saponaretin
/ Homovitexin
/ 6-C-beta-D-Glucopyranosylapigenin
/ 6-beta-D-Glucopyranosyl-4',5,7-trihydroxyflavone
/ 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL465360
CHEMBL1601394
C049772
28 / 20 / 19 No. 22 No. 15
C00001110 External link 512 Vitexin
/ Apigenin 8-C-glucoside
/ 8-D-Glucosyl-4',5,7-trihydroxyflavone
/ 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL487417
CHEMBL1332209
CHEMBL1357921
16 / 4 / 8 No. 22 No. 15
C00002078 External link 512 Anacrotine
C053598
No. 622 No. 2
C00002116 External link 512 Senecionine
CHEMBL362153
CHEMBL488203
C009237
8 / 1 / 5 1 / 1 No. 622 No. 2

Human Protein / Gene in interactions

36 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q01196 Runt-related transcription factor 1 Unclassified protein C00001059 C00001110 C00002116 1 / 4
Q9UNA4 DNA polymerase iota Enzyme C00001059 C00001110 C00002116 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001059 C00001110 C00002116 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00001059 C00001110 C00002116 0 / 1
Q9UBT6 DNA polymerase kappa Enzyme C00001059 C00001110 C00002116 0 / 0
P39748 Flap endonuclease 1 Enzyme C00001059 C00002116 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00001019 C00001059 1 / 0
O00255 Menin Unclassified protein C00001019 C00001059 2 / 5
P46063 ATP-dependent DNA helicase Q1 Enzyme C00001059 C00002116 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001019 C00001059 1 / 2
O75496 Geminin Unclassified protein C00001019 C00001110 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00001019 C00001059 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00001059 C00001110 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00001059 C00001110 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001059 C00001110 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00001019 C00001059 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00001059 C00001110 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001110 C00002116 0 / 1
P30989 Neurotensin receptor type 1 Neurotensin receptor C00001059 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001110 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001059 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001110 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001059 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001019 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001059 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00001059 7 / 3
P15121 Aldose reductase Enzyme C00001110 0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme C00001059 2 / 2
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001059 1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00001059 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001059 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001110 0 / 1
P10253 Lysosomal alpha-glucosidase Hydrolase C00001059 1 / 1
P06746 DNA polymerase beta Enzyme C00001059 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001110 1 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00001059 2 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
54657 UGT1A4, HUG-BR2, UDPGT, UDPGT_1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) C00002116

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc Q14191
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#174800 Mccune-albright syndrome; mas P63092
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (22)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H01205 Coumarin resistance P11712 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

1 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D064420 Drug-Related Side Effects and Adverse Reactions C00002116