Senecio gillesiano
Species
KNApSAcK Entry
| Organism name | Senecio gillesiano |
|---|---|
| Genus | Senecio |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Senecio |
|---|---|
| Linked NCBI taxonomy ID | 18794 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (3)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002109
|
Retrorsine
|
CHEMBL520570
CHEMBL496894 CHEMBL1321908 CHEMBL1599718 |
C003300
|
15 / 4 / 9 | 2 / 0 | No. 622 | No. 2 |
|
|
C00002116
|
Senecionine
|
CHEMBL362153
CHEMBL488203 |
C009237
|
8 / 1 / 5 | 1 / 1 | No. 622 | No. 2 |
|
|
C00013232
|
Platyphyllide
/ (-)-Platyphyllide / (1R,2R)-(-)-Platyphyllide / (8R-cis)-6,7,8,8a-Tetrahydro-8-(1-methylethenyl)-2H-naphtho[1,8-bc]furan-2-one |
No. 2664 |
|
Human Protein / Gene in interactions
17 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002109 C00002116 | 1 / 4 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002109 C00002116 | 0 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002109 C00002116 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002109 C00002116 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002109 C00002116 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002109 C00002116 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002109 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002109 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002109 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002109 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002116 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002109 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00002109 | 1 / 2 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002109 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002116 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002109 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002109 | 1 / 0 |
3 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00002109
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00002109
|
| 54657 | UGT1A4, HUG-BR2, UDPGT, UDPGT_1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D | UDP glucuronosyltransferase 1 family, polypeptide A4 (EC:2.4.1.17) |
C00002116
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (4)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
KEGG DISEASE (9)
| KEGG | name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|