PCIDB

Senecio nemorensis

Species

KNApSAcK Entry

Organism name Senecio nemorensis
Genus Senecio
Family Asteraceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Senecio nemorensis
Linked NCBI taxonomy ID 189242
Linked level species

Family

Family in NCBI taxonomy Asteraceae
ID 4210

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class asterids
ID 71274

Natural Activity

List (5)

Species Activity
Senecio nemorensis L. Carcinogenic
Senecio nemorensis L. Hemostat
Senecio nemorensis L. Hepatotoxic
Senecio nemorensis L. Hypoglycemic
Senecio nemorensis L. Hypotensive

Metabolite list (8)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00005413 External link 512 Rutin
/ Birutan
/ 3-Rutinosylquercetin
/ Quercetin 3-O-rutinoside
/ (+)-Quercetin 3-O-rutinoside
/ Quercetin 3-O-beta-rutinoside
/ (+)-Quercetin 3-O-beta-rutinoside
/ 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside
/ Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
CHEMBL32579
CHEMBL310754
CHEMBL182108
CHEMBL226335
CHEMBL502782
CHEMBL1436093
CHEMBL1532989
D012431
25 / 18 / 16 29 / 8 No. 1 No. 15
C00005374 External link 512 Quercetin
CHEMBL82242
CHEMBL479232
CHEMBL1437696
C012526
14 / 2 / 2 2 / 1 No. 2 No. 15
C00002724 External link 512 Heriguard
/ Chlorogenic acid
/ 3-O-Caffeoylquinic acid
CHEMBL284616
CHEMBL230481
CHEMBL249450
CHEMBL1332980
CHEMBL1394423
CHEMBL1419611
CHEMBL1473644
CHEMBL1552319
D002726
30 / 19 / 22 37 / 9 No. 314 No. 6
C00017393 External link 512 Senemorin
CHEMBL253986
No. 785
C00002670 External link 512 Pyrogallol
CHEMBL307145
D011748
115 / 69 / 60 8 / 2 No. 1590 No. 82
C00017394 External link 512 10alpha-Furanoligularenone
No. 2598
C00002102 External link 512 Nemorensine
CHEMBL507995
No. 2902 No. 2
C00001183 External link 512 Fumaric acid
CHEMBL503160
CHEMBL539648
C032005
17 / 14 / 46 0 / 1 No. 3766

Human Protein / Gene in interactions

156 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001183 C00002670 C00002724 C00005374 C00005413 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00002670 C00005374 C00005413 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00002670 C00002724 C00005374 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002670 C00002724 C00005413 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00002724 C00005374 C00005413 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00002670 C00002724 C00005374 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002670 C00002724 C00005413 0 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00002670 C00002724 C00005413 0 / 3
O75164 Lysine-specific demethylase 4A Enzyme C00001183 C00002724 C00005374 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001183 C00002670 C00002724 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00002670 C00002724 C00005413 3 / 3
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002670 C00002724 1 / 0
P06239 Tyrosine-protein kinase Lck Src C00002670 C00002724 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002670 C00002724 1 / 1
P22303 Acetylcholinesterase Hydrolase C00002670 C00005413 1 / 0
P03372 Estrogen receptor NR3A1 C00002670 C00005413 1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00002670 C00002724 2 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002670 C00002724 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002670 C00005413 0 / 0
P14679 Tyrosinase Oxidoreductase C00002670 C00005413 4 / 2
P04150 Glucocorticoid receptor NR3C1 C00002670 C00002724 0 / 1
P00915 Carbonic anhydrase 1 Lyase C00001183 C00002670 0 / 0
P10145 Interleukin-8 Secreted protein C00002670 C00002724 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001183 C00002724 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00005374 C00005413 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00001183 C00002670 1 / 2
P15121 Aldose reductase Enzyme C00002724 C00005374 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00002670 C00005413 0 / 0
O75496 Geminin Unclassified protein C00001183 C00002724 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00002670 C00002724 1 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002670 C00002724 0 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00002670 C00005413 0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00002670 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00002670 0 / 0
P02768 Serum albumin Secreted protein C00002670 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00002670 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00002670 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00002670 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00002670 1 / 0
P07237 Protein disulfide-isomerase Enzyme C00005374 0 / 0
Q9GZT9 Egl nine homolog 1 Enzyme C00001183 1 / 1
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005413 1 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00002670 1 / 8
P11388 DNA topoisomerase 2-alpha Isomerase C00005413 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00002670 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00002670 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00002670 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00002670 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00002670 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00002670 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00002670 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00002670 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00002670 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00002670 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00002670 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00002670 1 / 0
P35367 Histamine H1 receptor Histamine receptor C00002670 0 / 0
P16581 E-selectin Adhesion C00002670 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002670 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00001183 0 / 0
P39748 Flap endonuclease 1 Enzyme C00005374 0 / 0
P25021 Histamine H2 receptor Histamine receptor C00002670 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002724 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00002670 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00002670 0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00002670 1 / 1
P21917 D(4) dopamine receptor Dopamine receptor C00002670 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00002670 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00002670 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00002670 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00002670 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00002670 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00002670 0 / 1
P25101 Endothelin-1 receptor Endothelin receptor C00002670 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00002670 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002670 11 / 10
P32245 Melanocortin receptor 4 Melanocortin receptor C00002670 1 / 0
P14780 Matrix metalloproteinase-9 M10A C00002670 2 / 2
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00002670 0 / 0
P08311 Cathepsin G S1A C00002670 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005413 0 / 1
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00002670 1 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002724 1 / 2
P03956 Interstitial collagenase M10A C00002670 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00002670 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005374 1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005374 0 / 0
P11308 Transcriptional regulator ERG Unclassified protein C00001183 1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein C00001183 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00005413 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00002670 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002670 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002670 0 / 0
P17252 Protein kinase C alpha type Alpha C00002670 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00002670 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00002670 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00002670 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002670 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00002670 0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002724 0 / 0
P06276 Cholinesterase Hydrolase C00005413 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00002670 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00002670 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00002670 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00002670 1 / 0
P29466 Caspase-1 C14 C00002670 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00002670 2 / 1
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00001183 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00001183 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005413 2 / 0
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002724 1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00002670 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001183 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00002670 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00005413 1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00002670 1 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00002670 0 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002670 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00002670 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00002670 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002670 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00002670 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00002670 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00002670 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002670 0 / 0
P14151 L-selectin Adhesion C00002670 0 / 0
P16109 P-selectin Adhesion C00002670 1 / 0
P06746 DNA polymerase beta Enzyme C00005413 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00002670 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00002670 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00005374 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00002724 3 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00002670 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00002670 5 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00005413 4 / 3
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002724 0 / 0
P08246 Neutrophil elastase S1A C00002670 2 / 1
P10275 Androgen receptor NR3C4 C00002670 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00002670 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00002670 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00002670 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00002670 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00002670 1 / 1
P21728 D(1A) dopamine receptor Dopamine receptor C00002670 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00002670 0 / 0
P48147 Prolyl endopeptidase S9A C00005413 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00002724 0 / 0
Q16798 NADP-dependent malic enzyme, mitochondrial Enzyme C00001183 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00002670 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002724 3 / 3
Q9P1W9 Serine/threonine-protein kinase pim-2 Pim C00005374 0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00001183 7 / 37
Q13951 Core-binding factor subunit beta Unclassified protein C00002670 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00002670 1 / 4
P33527 Multidrug resistance-associated protein 1 drugs C00005413 0 / 0
Q9C0B1 Alpha-ketoglutarate-dependent dioxygenase FTO Unclassified protein C00001183 1 / 2

72 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005374 C00005413
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005374 C00005413
847 CAT catalase (EC:1.11.1.6) C00002670 C00005413
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00002670 C00005413
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00005413
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00002724
960 CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 CD44 molecule (Indian blood group) C00002724
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00002724
1277 COL1A1, OI4 collagen, type I, alpha 1 C00002724
4512 COX1, COI, MTCO1, MT-CO1 cytochrome c oxidase subunit I C00002724
114757 CYGB, HGB, STAP cytoglobin C00002724
1830 DSG3, CDHF6, PVA desmoglein 3 C00002724
1950 EGF, HOMG4, URG epidermal growth factor C00002724
2200 FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 fibrillin 1 C00002724
2201 FBN2, CCA, DA9 fibrillin 2 C00002724
2246 FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 fibroblast growth factor 1 (acidic) C00002724
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00002724
3036 HAS1, HAS hyaluronan synthase 1 (EC:2.4.1.212) C00002724
3315 HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 heat shock 27kDa protein 1 C00002724
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00002724
3852 KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A keratin 5 C00002724
4157 MC1R, CMM5, MSH-R, SHEP2 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) C00002724
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00002724
5241 PGR, NR3C3, PR progesterone receptor C00002724
8985 PLOD3, LH3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) C00002724
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002724
5886 RAD23A, HHR23A, HR23A RAD23 homolog A (S. cerevisiae) C00002724
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00002724
6256 RXRA, NR2B1 retinoid X receptor, alpha C00002724
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00002724
6716 SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) C00002724
7178 TPT1, HRF, TCTP, p02, p23 tumor protein, translationally-controlled 1 C00002724
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00002724
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00002724
7306 TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase-related protein 1 (EC:1.14.18.-) C00002724
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002724
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002724
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002724
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002724
351 APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 amyloid beta (A4) precursor protein C00002670
358 AQP1, AQP-CHIP, CHIP28, CO aquaporin 1 C00002724
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00002670
47 ACLY, ACL, ATPCL, CLATP ATP citrate lyase (EC:2.3.3.8) C00002724
1312 COMT catechol-O-methyltransferase (EC:2.1.1.6) C00002670
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00002670
6622 SNCA, NACP, PARK1, PARK4, PD1 synuclein, alpha (non A4 component of amyloid precursor) C00002670
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00002670
177 AGER, RAGE advanced glycosylation end product-specific receptor C00005413
196 AHR, bHLHe76 aryl hydrocarbon receptor C00005413
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00005413
581 BAX, BCL2L4 BCL2-associated X protein C00005413
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00005413
873 CBR1, CBR, SDR21C1, hCBR1 carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) C00005413
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00005413
360 AQP3, AQP-3, GIL aquaporin 3 (Gill blood group) C00002724
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00005413
2936 GSR glutathione reductase (EC:1.8.1.7) C00005413
3458 IFNG, IFG, IFI interferon, gamma C00005413
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00005413
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00005413
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00005413
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00005413
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00005413
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00005413
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00005413
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00005413
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00005413
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00005413
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00005413
7039 TGFA, TFGA transforming growth factor, alpha C00005413
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00005413
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (99)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#600807 Asthma, susceptibility to Q13093
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
#137800 Glioma susceptibility 1; glm1 P04626
#232300 Glycogen storage disease ii P10253
#245590 Growth hormone insensitivity with immunodeficiency P51692
#612938 Growth retardation, developmental delay, coarse facies, and early death; gdfd Q9C0B1
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#159900 Myoclonic dystonia P14416
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P16109
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (98)

KEGG name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P27487 (marker)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
P14679 (marker)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
P11308 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00409 Type II diabetes mellitus Q9C0B1 (related)
H00926 Growth retardation, developmental delay, coarse facies, and early death Q9C0B1 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

20 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00002724
C00002670
D015431 Weight Loss C00002724
D000647 Amnesia C00002724
D010146 Pain C00005374
D006937 Hypercholesterolemia C00002724
D006951 Hyperlipoproteinemias C00002724
D015228 Hypertriglyceridemia C00002724
D052456 Hypoalphalipoproteinemias C00002724
D008545 Melanoma C00002724
D009336 Necrosis C00002724
D002471 Cell Transformation, Neoplastic C00001183
D048629 Micronuclei, Chromosome-Defective C00002670
D001424 Bacterial Infections C00005413
D003092 Colitis C00005413
D004409 Dyskinesia, Drug-Induced C00005413
D015212 Inflammatory Bowel Diseases C00005413
D007674 Kidney Diseases C00005413
D028361 Mitochondrial Diseases C00005413
D010243 Paralysis C00005413
D013276 Stomach Ulcer C00005413