Galanthus caucasicus
Species
KNApSAcK Entry
| Organism name | Galanthus caucasicus |
|---|---|
| Genus | Galanthus |
| Family | Amaryllidaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Galanthus |
|---|---|
| Linked NCBI taxonomy ID | 4669 |
| Linked level | genus |
Family
| Family in NCBI taxonomy | Amaryllidaceae |
|---|---|
| ID | 4668 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (7)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00005413
|
Rutin
/ Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside |
CHEMBL32579
CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989 |
D012431
|
25 / 18 / 16 | 29 / 8 | No. 1 | No. 15 |
|
|
C00005372
|
Hyperin
/ Hyperoside / Quercetin 3-O-galactoside / Quercetin 3-O-beta-D-galactoside / Quercetin 3-beta-galactopyranoside / Quercetin 3-O-beta-D-galactopyranoside |
CHEMBL33027
CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 |
C021304
|
38 / 43 / 34 | 4 / 0 | No. 2 | No. 15 |
|
|
C00024438
|
Tazettine
/ (+)-Tazettine |
CHEMBL457605
CHEMBL1720510 CHEMBL1997188 |
C011361
|
6 / 1 / 0 | No. 103 | No. 4 |
|
|
|
C00001570
|
Jilkon
/ Lycoremin / Lycoremine / Galanthamine / (-)-Galanthamine |
CHEMBL659
CHEMBL492193 CHEMBL1565544 CHEMBL1623394 CHEMBL1624158 |
D005702
|
104 / 57 / 53 | 3 / 25 | No. 580 | No. 4 |
|
|
C00024390
|
Galanthine
/ (-)-Galanthine |
CHEMBL1172893
|
No. 633 | No. 4 |
|
|||
|
C00024387
|
Demethylhomolycorine
/ 8-O-Demethylhomolycorine / 9-O-Demethylhomolycorine / (+)-8-O-Demethylhomolycorine |
CHEMBL1979251
|
No. 715 |
|
||||
|
C00001576
|
Lycorine
/ (-)-Lycorine |
CHEMBL224745
CHEMBL400092 CHEMBL583716 CHEMBL577635 CHEMBL1592744 CHEMBL1593638 |
C015330
|
20 / 24 / 18 | 5 / 5 | No. 1156 | No. 4 |
|
Human Protein / Gene in interactions
149 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00001570 C00001576 C00005372 C00005413 | 0 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00001570 C00001576 C00005413 C00024438 | 1 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001576 C00005372 C00005413 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001570 C00001576 C00005372 | 11 / 10 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001576 C00005372 C00005413 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001576 C00005372 C00005413 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00001570 C00005372 C00005413 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001570 C00001576 C00005413 | 0 / 1 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00001570 C00005372 C00005413 | 0 / 3 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00005372 C00005413 | 1 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001570 C00001576 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001570 C00001576 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00001570 C00005372 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00005372 C00005413 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00005372 C00005413 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001570 C00005413 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005372 C00024438 | 0 / 0 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00005372 C00005413 | 2 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001570 C00001576 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00005372 C00005413 | 4 / 3 |
| P06276 | Cholinesterase | Hydrolase | C00001570 C00005413 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001576 C00005372 | 4 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00005372 C00005413 | 1 / 1 |
| P14679 | Tyrosinase | Oxidoreductase | C00005372 C00005413 | 4 / 2 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00001570 C00005372 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00001570 C00005413 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00005372 C00024438 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00001570 C00005372 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00001570 C00001576 | 2 / 3 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00001576 C00005413 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001570 C00001576 | 1 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005372 C00005413 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001570 C00001576 | 0 / 1 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00001570 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00001570 | 0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00001570 | 0 / 0 |
| Q13224 | Glutamate receptor ionotropic, NMDA 2B | NS | C00001570 | 1 / 0 |
| Q05586 | Glutamate receptor ionotropic, NMDA 1 | NS | C00001570 | 1 / 0 |
| Q12879 | Glutamate receptor ionotropic, NMDA 2A | NS | C00001570 | 0 / 0 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00005372 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00001570 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00001570 | 1 / 8 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00001576 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001570 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00001570 | 1 / 0 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00001570 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001570 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00001570 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00001570 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00001570 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00001570 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00001570 | 0 / 0 |
| P05067 | Amyloid beta A4 protein | Membrane receptor | C00001570 | 2 / 2 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00001570 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00001570 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00001570 | 1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001570 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00005372 | 1 / 1 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00001570 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00001576 | 0 / 0 |
| Q92630 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | CMGC dual-specificity kinase DYRK2 | C00001570 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00005372 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001570 | 0 / 0 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00001570 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001570 | 0 / 0 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00001570 | 1 / 1 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00001570 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00001570 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00001570 | 1 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00001570 | 0 / 1 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00001570 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00001570 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00005372 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00001570 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00001570 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00001570 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00001570 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00001570 | 0 / 0 |
| P27487 | Dipeptidyl peptidase 4 | S9B | C00005413 | 0 / 1 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00001570 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00024438 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00001570 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00001570 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00005372 | 1 / 1 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005372 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005372 | 3 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00024438 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00005413 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001570 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001570 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001570 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00001570 | 1 / 2 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00001570 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00001570 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00001570 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001570 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00001570 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00001570 | 2 / 2 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00001570 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00001570 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00001570 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00005372 | 1 / 1 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00001570 | 1 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00001570 | 0 / 0 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005372 | 0 / 1 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00001570 | 2 / 1 |
| P56817 | Beta-secretase 1 | A1A | C00001570 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00001570 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00005413 | 3 / 3 |
| P29466 | Caspase-1 | C14 | C00001570 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00024438 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00001570 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00005372 | 6 / 4 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00001570 | 1 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00001570 | 0 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00001570 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00001570 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00001570 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001570 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00001570 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00001570 | 0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00001570 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00001570 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00001570 | 2 / 1 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00001570 | 2 / 2 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00001570 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00001570 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001576 | 2 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00001576 | 1 / 1 |
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00005372 | 1 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00001570 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00001570 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00001570 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00001570 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00001570 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00001570 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00001570 | 0 / 0 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005372 | 1 / 1 |
| P48147 | Prolyl endopeptidase | S9A | C00005413 | 0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | C00001570 | 1 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00005372 | 0 / 0 |
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00005372 | 0 / 0 |
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00005413 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001576 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00001570 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001570 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00005372 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00005372 | 1 / 4 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00005372 | 0 / 0 |
39 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00001576
C00005413
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00005372
C00005413
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00005413
|
| 10507 | SEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D |
C00001576
|
| 896 | CCND3 | cyclin D3 |
C00001576
|
| 1003 | CDH5, 7B4, CD144 | cadherin 5, type 2 (vascular endothelium) |
C00001576
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00005372
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00005372
|
| 23411 | SIRT1, SIR2L1 | sirtuin 1 |
C00005372
|
| 43 | ACHE, ACEE, ARACHE, N-ACHE, YT | acetylcholinesterase (EC:3.1.1.7) |
C00001570
|
| 1137 | CHRNA4, BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
C00001570
|
| 1141 | CHRNB2, EFNL3, nAChRB2 | cholinergic receptor, nicotinic, beta 2 (neuronal) |
C00001570
|
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor |
C00005413
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00005413
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00005413
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00005413
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00005413
|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00005413
|
| 873 | CBR1, CBR, SDR21C1, hCBR1 | carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) |
C00005413
|
| 1026 | CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
C00001576
|
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 |
C00005413
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00005413
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00005413
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00005413
|
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) |
C00005413
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00005413
|
| 3480 | IGF1R, CD221, IGFIR, IGFR, JTK13 | insulin-like growth factor 1 receptor (EC:2.7.10.1) |
C00005413
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00005413
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00005413
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00005413
|
| 3667 | IRS1, HIRS-1 | insulin receptor substrate 1 |
C00005413
|
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene |
C00005413
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00005413
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00005413
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00005413
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00005413
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00005413
|
| 7039 | TGFA, TFGA | transforming growth factor, alpha |
C00005413
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00005413
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (96)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #104300 | Alzheimer disease; ad |
P05067
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605714 | Cerebral amyloid angiopathy, app-related |
P05067
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613970 | Mental retardation, autosomal dominant 6; mrd6 |
Q13224
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #614254 | Mental retardation, autosomal dominant 8; mrd8 |
Q05586
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #159900 | Myoclonic dystonia |
P14416
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #614674 | Periodic fever, menstrual cycle-dependent |
P08908
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (77)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00056 | Alzheimer's disease (AD) |
P05067
(related)
|
| H01185 | Cerebral amyloid angiopathy (CAA) |
P05067
(related)
|
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H00032 | Thyroid cancer |
P27487
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00192 | Xanthinuria |
P47989
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
36 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D014839 | Vomiting |
C00001576
C00001570 |
| D010243 | Paralysis |
C00001570
C00005413 |
| D007022 | Hypotension |
C00001570
|
| D012772 | Shock, Septic |
C00001576
|
| D009325 | Nausea |
C00001576
|
| D000544 | Alzheimer Disease |
C00001570
|
| D000647 | Amnesia |
C00001570
|
| D054537 | Atrioventricular Block |
C00001570
|
| D001321 | Autistic Disorder |
C00001570
|
| D001919 | Bradycardia |
C00001570
|
| D003072 | Cognition Disorders |
C00001570
|
| D003693 | Delirium |
C00001570
|
| D015140 | Dementia, Vascular |
C00001570
|
| D003967 | Diarrhea |
C00001570
|
| D062787 | Drug Overdose |
C00001570
|
| D004421 | Dystonia |
C00001570
|
| D006261 | Headache |
C00001570
|
| D006948 | Hyperkinesis |
C00001570
|
| D010051 | Ovarian Neoplasms |
C00001576
|
| D007859 | Learning Disorders |
C00001570
|
| D008133 | Long QT Syndrome |
C00001570
|
| D020258 | Neurotoxicity Syndromes |
C00001570
|
| D009389 | Neovascularization, Pathologic |
C00001576
|
| D010259 | Paranoid Disorders |
C00001570
|
| D011041 | Poisoning |
C00001570
|
| D049188 | Prenatal Injuries |
C00001570
|
| D012640 | Seizures |
C00001570
|
| D013575 | Syncope |
C00001570
|
| D014202 | Tremor |
C00001570
|
| D001424 | Bacterial Infections |
C00005413
|
| D003092 | Colitis |
C00005413
|
| D004409 | Dyskinesia, Drug-Induced |
C00005413
|
| D015212 | Inflammatory Bowel Diseases |
C00005413
|
| D007674 | Kidney Diseases |
C00005413
|
| D028361 | Mitochondrial Diseases |
C00005413
|
| D013276 | Stomach Ulcer |
C00005413
|