KCF-S cluster No. 103 (45 metabolites)

Corresponding Phytochemical cluster No. 4

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (45)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
Liliopsida	189

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Cumulative family count

class name	count
Amaryllidaceae	188
Dioscoreaceae	1

KEGG BRITE br08003

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Categories (2)

br08003 Category	# of metabolite
Isoquinoline alkaloids	4
Indole alkaloids	1

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metabolites link (5)

br08003 Category	KEGG ID	KNApSAcK ID
Isoquinoline alkaloids	C08517	C00001561
Isoquinoline alkaloids	C08525	C00001569
Isoquinoline alkaloids	C08527	C00001571
Isoquinoline alkaloids	C12162	C00024384
Indole alkaloids	C12179	C00024438

Metabolite list (45)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001561	Ambelline / (-)-Ambelline	CHEMBL1173110 CHEMBL1600436 CHEMBL1980252		1 / 0 / 1
C00001569	Crinamine	CHEMBL401114 CHEMBL516991 CHEMBL1172810 CHEMBL1221865 CHEMBL1551610 CHEMBL1995397	C411129	5 / 6 / 3
C00001571	Haemanthamine	CHEMBL401114 CHEMBL516991 CHEMBL1172810 CHEMBL1221865 CHEMBL1551610 CHEMBL1995397	C462104	5 / 6 / 3
C00001580	Pretazettine	CHEMBL606758 CHEMBL2010422	C010766
C00024354	Yemenine A / 3-Acetylhamayne / 3-O-Acetylhamayne / Hamayne 3-acetate / O-Demethylcrinamine 3-acetate	CHEMBL469438
C00024355	Yemenine A / 3-O-Acetyl hamayne	CHEMBL469438
C00024357	6alpha-Hydroxycrinine
C00024358	6beta-Hydroxycrinine
C00024359	6-Hydroxycrinamine	CHEMBL404212 CHEMBL512669 CHEMBL465820 CHEMBL1169873 CHEMBL1172881 CHEMBL2006644		1 / 1 / 0
C00024360	6-Methoxycrinamine	CHEMBL2087243
C00024370	Bulbispermine	CHEMBL250055 CHEMBL511614 CHEMBL1993537 CHEMBL2087241
C00024371	Buphanisine	CHEMBL512945
C00024384	Crinine / Crinidine	CHEMBL469648 CHEMBL1221864 CHEMBL1971343		3 / 1 / 0
C00024391	Pancratine / Hemanthidine / Haemanthidine	CHEMBL404212 CHEMBL512669 CHEMBL465820 CHEMBL1169873 CHEMBL1172881 CHEMBL2006644	C083906	1 / 1 / 0
C00024392	Hamayne / Bulbispermine	CHEMBL250055 CHEMBL511614 CHEMBL1993537 CHEMBL2087241
C00024416	Krepowine / O-Acetylcrinine / 3-O-Acetylcrinine
C00024425	Pancratine / Haemanthidine	CHEMBL404212 CHEMBL512669 CHEMBL465820 CHEMBL1169873 CHEMBL1172881 CHEMBL2006644	C083906	1 / 1 / 0
C00024429	Powellin / Powelline
C00024438	Tazettine / (+)-Tazettine	CHEMBL457605 CHEMBL1720510 CHEMBL1997188	C011361	6 / 1 / 0
C00024446	Vittatine	CHEMBL469648 CHEMBL1221864 CHEMBL1971343		3 / 1 / 0
C00027615	(+)-11-Hydroxyvittatine	CHEMBL250055 CHEMBL511614 CHEMBL1993537 CHEMBL2087241
C00027620	(+)-3,4-Dihydro-3-hydroxygraciline
C00027621	(+)-3-epi-3,4-Dihydro-3-hydroxygraciline
C00027622	(+)-3-O-(3-Hydroxybutyryl)tazettinol
C00027623	(+)-3-O-demethyl-3-epimacronine
C00027630	(+)-Graciline
C00027631	(+)-Isotazettinol
C00027662	11-O-Acetylambelline
C00027663	11-O-Acetylhaemanthamine	CHEMBL2087244
C00027746	Epimacronine / 3-Epimacronine	CHEMBL1976572
C00027753	3-O-demethyltazettine / (+)-3-O-Demethyltazettine
C00027766	6alpha-Hydroxypowelline
C00027779	8alpha-Ethoxyprecriwelline
C00027877	Apohaemanthamine	CHEMBL2087253	C411130
C00027975	Brunsbelline	CHEMBL1173110 CHEMBL1600436 CHEMBL1980252		1 / 0 / 1
C00027990	Bujeine
C00027991	Buphanidrine	CHEMBL2009061 CHEMBL2146603
C00028102	Criwelline	CHEMBL457605 CHEMBL1720510 CHEMBL1997188		6 / 1 / 0
C00028245	Epibuphanisine / (+)-3-Epibuphanisine	CHEMBL512945
C00028251	Epivittatine	CHEMBL469648 CHEMBL1221864 CHEMBL1971343		3 / 1 / 0
C00029079	Tazettadiol
C00039086	Egonine
C00047153	6-O-Methylhaemanthidine	CHEMBL2087243
C00047330	Pancratinine B / (+)-Pancratinine B
C00047331	Pancratinine C / (-)-Pancratinine C

Human Protein / Gene in interactions

12 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P22303	Acetylcholinesterase	Hydrolase	C00001569 C00001571 C00024359 C00024384 C00024391 C00024425 C00024438 C00024446 C00028102 C00028251	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001561 C00001569 C00001571 C00027975	0 / 1
P11388	DNA topoisomerase 2-alpha	Isomerase	C00024384 C00024446 C00028251	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00024384 C00024446 C00028251	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00001569 C00001571	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00024438 C00028102	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00024438 C00028102	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00024438 C00028102	0 / 0
O75496	Geminin	Unclassified protein	C00024438 C00028102	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00001569 C00001571	4 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00024438 C00028102	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001569 C00001571	1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions