Centranthus longiflorus ssp. longiflorus

• Index
• Plant Species
• Metabolite list (3)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Centranthus longiflorus ssp. longiflorus
Genus	Centranthus
Family	Valerianaceae / Linnaeaceae / Dipsacaceae / Diervillaceae
Kingdom	Plantae

---

NCBI taxonomy

Entry

Linked NCBI taxonomy name	Centranthus
Linked NCBI taxonomy ID	42331
Linked level	genus

Family

Family in NCBI taxonomy	Caprifoliaceae
ID	4200

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Metabolite list (3)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005413	Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989	D012431	25 / 18 / 16	29 / 8	No. 1	No. 15
C00019064	Oleanolic acid / Astrantiagenin C / Virgaureagenin B / 3beta-Hydroxyolean-12-en-28-oic acid	CHEMBL56615 CHEMBL168 CHEMBL180553 CHEMBL365375 CHEMBL486382 CHEMBL1413646 CHEMBL1436454	D009828	30 / 8 / 12	21 / 15	No. 13	No. 51
C00010645	Patrinoside		C008771			No. 663

Human Protein / Gene in interactions

52 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00005413 C00019064	0 / 3
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00005413 C00019064	0 / 0
P06746	DNA polymerase beta	Enzyme	C00005413 C00019064	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00005413	4 / 2
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00019064	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00005413	1 / 1
Q06124	Tyrosine-protein phosphatase non-receptor type 11	Tyr	C00019064	4 / 2
P24666	Low molecular weight phosphotyrosine protein phosphatase	Tyr	C00019064	0 / 0
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00019064	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00019064	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00005413	1 / 1
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00019064	0 / 0
P10586	Receptor-type tyrosine-protein phosphatase F	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00005413	1 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00005413	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00019064	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00019064	0 / 0
O75496	Geminin	Unclassified protein	C00019064	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00005413	0 / 0
P15121	Aldose reductase	Enzyme	C00019064	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00019064	0 / 0
P27487	Dipeptidyl peptidase 4	S9B	C00005413	0 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00019064	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00005413	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00019064	2 / 2
P33527	Multidrug resistance-associated protein 1	drugs	C00005413	0 / 0
P06276	Cholinesterase	Hydrolase	C00005413	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00019064	0 / 0
P18433	Receptor-type tyrosine-protein phosphatase alpha	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00019064	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00005413	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00005413	3 / 3
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00005413	2 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00019064	0 / 0
P03372	Estrogen receptor	NR3A1	C00005413	1 / 1
P22303	Acetylcholinesterase	Hydrolase	C00005413	1 / 0
P35228	Nitric oxide synthase, inducible	Enzyme	C00019064	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00005413	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00019064	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00019064	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00005413	4 / 3
P17706	Tyrosine-protein phosphatase non-receptor type 2	Tyr	C00019064	0 / 1
P29350	Tyrosine-protein phosphatase non-receptor type 6	Tyr	C00019064	0 / 0
P48147	Prolyl endopeptidase	S9A	C00005413	0 / 0
P04054	Phospholipase A2	Enzyme	C00019064	0 / 0
P23469	Receptor-type tyrosine-protein phosphatase epsilon	Receptor tyrosine-protein phosphatase	C00019064	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00005413	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00005413	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00005413	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00019064	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00019064	1 / 4

44 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00005413 C00019064
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00005413 C00019064
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00005413 C00019064
847	CAT	catalase (EC:1.11.1.6)	C00005413 C00019064
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00005413 C00019064
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00005413 C00019064
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00005413
3065	HDAC1, GON-10, HD1, RPD3, RPD3L1	histone deacetylase 1 (EC:3.5.1.98)	C00019064
3146	HMGB1, HMG1, HMG3, SBP-1	high mobility group box 1	C00019064
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00019064
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00019064
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00019064
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00019064
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00019064
5052	PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2	peroxiredoxin 1 (EC:1.11.1.15)	C00019064
5728	PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1	phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48)	C00019064
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00019064
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00019064
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00019064
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00019064
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00019064
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00005413
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00019064
581	BAX, BCL2L4	BCL2-associated X protein	C00005413
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00005413
873	CBR1, CBR, SDR21C1, hCBR1	carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184)	C00005413
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00005413
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00005413
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00005413
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00005413
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00005413
2936	GSR	glutathione reductase (EC:1.8.1.7)	C00005413
3458	IFNG, IFG, IFI	interferon, gamma	C00005413
3480	IGF1R, CD221, IGFIR, IGFR, JTK13	insulin-like growth factor 1 receptor (EC:2.7.10.1)	C00005413
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00005413
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00005413
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00005413
3667	IRS1, HIRS-1	insulin receptor substrate 1	C00005413
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00005413
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00005413
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00005413
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00005413
7039	TGFA, TFGA	transforming growth factor, alpha	C00005413
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00005413

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions